Interrelationships of human interferon-gamma with lymphotoxin and monocyte cytotoxin.

Stone-Wolff, Donna S.; Yip, Y. K.; Kelker, H C; Le, Junming; Henriksen‐DeStefano, Dorothy; Rubin, Berish Y.; Rinderknecht, Ernst; Aggarwal, Bharat B.; Vilček, Ján

doi:10.1084/jem.159.3.828

Cited by 182 publications

(67 citation statements)

References 33 publications

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“…(rBoIFN-~, rPoIFN-v and rBoTNF-c0. Synergistic activities resulting from mixtures of IFN-v and other IFN types have been described for antiviral activity (Domke et al, 1985) or cell growth inhibition (Czarniecki et aL, 1984;Fleischmann, 1982) and IFN-v synergizes with TNF for induction of activated macrophages (Esparza et al, 1987), cytotoxic activity (Stone-Wolff et al, 1984), differentiation of human myeloid cell lines (Trinchieri et al, 1986) or antiviral activity (Wong & Goeddel, 1986). However, our results indicate that the cytokines used had no synergism as antiviral agents against ASF virus.…”

Section: Discussioncontrasting

confidence: 54%

Effect of Interferon- , Interferon- and Tumour Necrosis Factor on African Swine Fever Virus Replication in Porcine Monocytes and Macrophages

Esparza

González

Viñuela

1988

Journal of General Virology

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SUMMARYBovine interferon-0ql (IFN-cti1) and porcine interferon-y (IFN-~) inhibited African swine fever virus replication in both porcine monocytes and alveolar macrophages. The most potent antiviral activity was observed with IFN-y-treated alveolar macrophages. The production of both a virulent (CC83) and a non-virulent (BA71) isolate of the virus was inhibited. Bovine turnout necrosis factor ~ did not show antiviral activity in either monocytes or alveolar macrophages. Rather, an increase of African swine fever virus production in tumour necrosis factor or-treated monocytes was found. An analysis of viral protein synthesis in IFN-~tI1-and IFN-~,-treated alveolar macrophages showed an inhibition of synthesis of some viral proteins. The inhibition of late proteins was very pronounced in IFN-~-treated cells, and it was probably a consequence of the inhibition of African swine fever virus DNA polymerase activity.

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Section: Discussioncontrasting

confidence: 54%

Effect of Interferon- , Interferon- and Tumour Necrosis Factor on African Swine Fever Virus Replication in Porcine Monocytes and Macrophages

Esparza

González

Viñuela

1988

Journal of General Virology

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“…Although much is known about TNF-a, very little is understood about TNF-b (Aggarwal, 2003;Aggarwal et al, 2012). Both overlapping and nonoverlapping activities of the two molecules have been reviewed (Stone-Wolff et al, 1984;Kuprash et al, 2002;Liepinsh et al, 2006).…”

Section: Discovery Of Tnfsmentioning

confidence: 99%

Curcumin: an orally bioavailable blocker of TNF and other pro‐inflammatory biomarkers

Aggarwal

Gupta

Sung

2013

British J Pharmacology

343

239

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TNFs are major mediators of inflammation and inflammation-related diseases, hence, the United States Food and Drug Administration (FDA) has approved the use of blockers of the cytokine, TNF-a, for the treatment of osteoarthritis, inflammatory bowel disease, psoriasis and ankylosis. These drugs include the chimeric TNF antibody (infliximab), humanized TNF-a antibody (Humira) and soluble TNF receptor-II (Enbrel) and are associated with a total cumulative market value of more than $20 billion a year. As well as being expensive ($15 000-20 000 per person per year), these drugs have to be injected and have enough adverse effects to be given a black label warning by the FDA. In the current report, we describe an alternative, curcumin (diferuloylmethane), a component of turmeric (Curcuma longa) that is very inexpensive, orally bioavailable and highly safe in humans, yet can block TNF-a action and production in in vitro models, in animal models and in humans. In addition, we provide evidence for curcumin's activities against all of the diseases for which TNF blockers are currently being used. Mechanisms by which curcumin inhibits the production and the cell signalling pathways activated by this cytokine are also discussed. With health-care costs and safety being major issues today, this golden spice may help provide the solution. LINKED ARTICLESThis article is part of a themed section on Emerging Therapeutic Aspects in Oncology. To view the other articles in this section visit http://dx

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“…Cytokines have pleiotropic effects (Sporn & Roberts, 1988) : IFN-y and TNF-a have been shown to play a role in vitro in the induction of class I1 MHC molecules on thyroid cells (Todd et al, 1988). They also have effects on other aspects of thyroid cell physiology since TNF-a has been reported to be one of the essential mediators of antibody-dependent cytotoxicity (ADCC) (Kondo et al, 1981) and cell killing by natural killer (NK) cells (Degliantoni et al, 1986) .This cytokine acts synergistically with IFN-y (Lee et al, 1984;Tsujimoto et al, 1986;Ruggiero et al, 1986;Taverne et al, 1987), which has also been shown to be cytotoxic (Stone-Wolff et al, 1984) and to increase expression of TNF receptors on the surface of tumour cells (Tsujimoto et al, 1986;Ruggiero et al, 1986). On the other hand, IFN-y has been reported to be secreted by lymphocytes isolated from peripheral blood (PB) (Hovdenes et al, 1989;Matsubayashi et al, 1990) or thyroid gland (Karlsson et al, 1986;Sat0 et al, 1993).…”

mentioning

confidence: 99%

Thyroid cell survival in coculture with autologous peripheral or intrathyroidal lymphocytes

Massart¹,

Glbassler²,

Gall³

et al. 1995

Clinical Endocrinology

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Summary OBJECTIVE We have studied lymphocyte Induced cytotoxicity and the production of interferon gamma (IFN‐α) and tumour necrosis factor alpha (TNF‐α) during coculture of thyrocytes and autologous lymphocytes from patients with Graves' disease and from normal subjects. PATIENTS Thyroid tissues and lymphocytes were obtained from 28 patients with Graves' disease and from 9 control subjects. MEASUREMENTS Lymphocyte induced cytotoxicity was evaluated on autologous thyrocytes using 5 metabolic tests: the MTT assay, the neutral red uptake, lactate dehydrogenase measurement and glutathione assay. IFN‐γ and TNF‐α measurements were performed after 1, 5 or 7 days' coculture. RESULTS The lymphocytes Isolated from peripheral blood (PB lymphocytes) altered the morphology and the metabolism of autologous thyrocytes. The Intrathyroidal lymphocytes Isolated after Dispase digestion were not toxic whereas mechanically Isolated lymphocytes exerted a little toxicity. No difference was seen between Graves' disease and normal cells.The supernatants from cocultures had higher IFN‐γ levels than those from lymphocyte cultures, in coculture, PB lymphocytes secreted more IFN‐γ and TNF‐α than Intrathyroidal lymphocytes. The PB lymphocyte Induced cytotoxicity was not due to IFN‐γ and TNF‐α alone. CONCLUSION Peripheral blood lymphocytes are cytotoxic in vitro to autologous thyrocytes whereas Intrathyroidal lymphocytes exert little or no cytotoxicity according to their isolation method. The mechanisms of lymphocyte Induced toxicity remain to be explained.

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Interrelationships of human interferon-gamma with lymphotoxin and monocyte cytotoxin.

Cited by 182 publications

References 33 publications

Effect of Interferon- , Interferon- and Tumour Necrosis Factor on African Swine Fever Virus Replication in Porcine Monocytes and Macrophages

Effect of Interferon- , Interferon- and Tumour Necrosis Factor on African Swine Fever Virus Replication in Porcine Monocytes and Macrophages

Curcumin: an orally bioavailable blocker of TNF and other pro‐inflammatory biomarkers

Thyroid cell survival in coculture with autologous peripheral or intrathyroidal lymphocytes

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