Interrelationships of Serum Paraoxonase, Serum Lipids and Apolipoproteins in Normal Pregnancy

Roy, A.C.; Loke, D. F. M.; Saha, N.; Viegas, O. A. C.; Tay, J. S. H.; Ratnam, S. S.

doi:10.1159/000292435

Cited by 21 publications

(15 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…mice are more susceptible to organophosphate toxicity (Shih et al 1998). A previous study (Roy et al 1994) reported a negative correlation between PON1 activity and birth weight. We found no significant relationship between PON1 activity or PON1 genes and birth weight.…”

Section: Discussionmentioning

confidence: 95%

In utero pesticide exposure, maternal paraoxonase activity, and head circumference.

Berkowitz

Wetmur²,

Birman-Deych³

et al. 2004

Environ Health Perspect

307

261

View full text Add to dashboard Cite

Although the use of pesticides in inner-city homes of the United States is of considerable magnitude, little is known about the potentially adverse health effects of such exposure. Recent animal data suggest that exposure to pesticides during pregnancy and early life may impair growth and neurodevelopment in the offspring. To investigate the relationship among prenatal pesticide exposure, paraoxonase (PON1) polymorphisms and enzyme activity, and infant growth and neurodevelopment, we are conducting a prospective, multiethnic cohort study of mothers and infants delivered at Mount Sinai Hospital in New York City. In this report we evaluate the effects of pesticide exposure on birth weight, length, head circumference, and gestational age among 404 births between May 1998 and May 2002. Pesticide exposure was assessed by a prenatal questionnaire administered to the mothers during the early third trimester as well as by analysis of maternal urinary pentachlorophenol levels and maternal metabolites of chlorpyrifos and pyrethroids. Neither the questionnaire data nor the pesticide metabolite levels were associated with any of the fetal growth indices or gestational age. However, when the level of maternal PON1 activity was taken into account, maternal levels of chlorpyrifos above the limit of detection coupled with low maternal PON1 activity were associated with a significant but small reduction in head circumference. In addition, maternal PON1 levels alone, but not PON1 genetic polymorphisms, were associated with reduced head size. Because small head size has been found to be predictive of subsequent cognitive ability, these data suggest that chlorpyrifos may have a detrimental effect on fetal neurodevelopment among mothers who exhibit low PON1 activity.

show abstract

Section: Discussionmentioning

confidence: 95%

In utero pesticide exposure, maternal paraoxonase activity, and head circumference.

Berkowitz

Wetmur²,

Birman-Deych³

et al. 2004

Environ Health Perspect

307

261

View full text Add to dashboard Cite

show abstract

“…Several nongenetic factors seem to contribute to modulating serum PON levels: diet [23], acute phase reactants [24], pregnancy [25], hormonal factors [26], cigarette smoking [27] and statin therapy [28]. PON can also act as a lactonase on statins, producing metabolites with antioxidant properties.…”

Section: Discussionmentioning

confidence: 99%

The effects of lipid-lowering therapy on paraoxonase activities and their relationships with the oxidant???antioxidant system in patients with dyslipidemia

Kural¹,

Örem

Uydu

et al. 2004

Coronary Artery Disease

View full text Add to dashboard Cite

show abstract

“…High-density lipoprotein (HDL) cholesterol is also increased. 81 The triglyceride, fatty acid and LDL cholesterol changes are accentuated but HDL reduced in PE. 68,82 Changes in fatty acids and triglycerides antedate clinically evident PE.…”

Section: Lipids In Pre-eclampsiamentioning

confidence: 99%

Hypertension in pregnancy

Pipkin

Roberts

2000

J Hum Hypertens

View full text Add to dashboard Cite

Hypertension arising during pregnancy remains one of the two most frequently-cited causes of maternal death in the UK. In some cases, pregnancy is unmasking underlying hypertension, which manifests itself in later life. Pregnant women who develop de novo proteinuric hypertension (pre-eclampsia, PE) can share many risk factors with patients with the metabolic syndrome, such as obesity, dyslipidaemia and insulin resistance. However, more than half the women who develop PE remain normotensive thereafter. There is a genetic component(s) to the disease, but it is most improbable that there is a 'PE gene'. Rather, there are factors such as geneticallydetermined thrombophilias which are predisposers but not prerequisites. Impaired placentation is a feature, with inadequate invasion of the spiral arteries by syncytiotrophoblast and poor remodelling. However, similiar features are found in association with non-hypertensive

show abstract

Interrelationships of Serum Paraoxonase, Serum Lipids and Apolipoproteins in Normal Pregnancy

Cited by 21 publications

References 8 publications

In utero pesticide exposure, maternal paraoxonase activity, and head circumference.

In utero pesticide exposure, maternal paraoxonase activity, and head circumference.

The effects of lipid-lowering therapy on paraoxonase activities and their relationships with the oxidant???antioxidant system in patients with dyslipidemia

Hypertension in pregnancy

Contact Info

Product

Resources

About