Interrogating the plasma proteome of repetitive head impact exposure and chronic traumatic encephalopathy
Rowan Saloner,
Kaitlin B. Casaletto,
Sruti Rayaprolu
et al.
Abstract:Background: Exposure to repetitive head impacts (RHI) is associated with increased risk for chronic traumatic encephalopathy (CTE), a neurodegenerative tauopathy, and other neuropathological changes. Biological drivers of RHI-related neurodegeneration are not well understood. We interrogated the plasma proteome in aging adults with prior RHI compared to healthy controls (CTL) and individuals with Alzheimer's disease (AD), including a subset characterized neuropathologically at autopsy. Methods: Proximity exten… Show more
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