Since March 2020, families across the U.S. have faced challenges due to the novel Coronavirus (COVID-19) and its subsequent restrictions. Prior literature has linked family stress to negative outcomes, such as parent and child mental health, increased risk of child maltreatment, and overall well-being, as well as protective factors that may help families navigate and respond to stressors. Furthermore, parental history of trauma, such as exposure to adversity in one’s own childhood, has been linked to stress and resilience. Although some experts have voiced concern over the impact of COVID-19 on family well-being, few studies have been conducted thus far. This study utilized N = 523 responses from an online survey that was administered between May and June 2020 to gauge family stress and resilience among parents of children ages zero-to-five during the pandemic. There was a negative relationship between ACE score and parental resilience among this sample. Furthermore, frequency of childcare was positively linked to protective factors and resilience, while childcare barriers were negatively linked to resilience. Implications for practice, policy, and research are discussed, with a particular focus on the role of childcare and school openings during the pandemic.