Interrupting Prolonged Sitting Reduces Postprandial Glucose Concentration in Young Men With Central Obesity

Wongpipit, Waris; Zhang, Xiaoyuan; Miyashita, Masashi; Wong, Seng Kai

doi:10.1210/clinem/dgaa834

Cited by 5 publications

(6 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although interrupting prolonged sitting with PA breaks has been clearly shown to produce marked and meaningful improvements in PPG and insulin metabolism [ 17 , 23 , 55 ], the effectiveness of accumulated exercise compared to a single session of energy-matched continuous exercise has not been well established [ 13 , 18 ]. Our findings suggest that accumulated exercise is an effective and feasible alternative for gaining health benefits; such activities can be even more meaningful for those who are sedentary and spend limited time doing exercise in one session [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Accumulated Versus Continuous Exercise on Postprandial Glycemia, Insulin, and Triglycerides in Adults with or Without Diabetes: A Systematic Review and Meta-Analysis

Zhang

Zheng

et al. 2022

Sports Med - Open

Self Cite

View full text Add to dashboard Cite

Background Postprandial dysmetabolism, an important cardiovascular disease risk factor, can be improved by exercise. Further systematic review and meta-analysis is needed to compare the effects of accumulated exercise with a single session of energy-matched continuous exercise on postprandial glucose (PPG), insulin, and triglycerides in adults with or without diabetes. Methods Eight electronic databases were searched on August 28, 2020, and updated on April 27, 2021. Eligible studies were randomized, quasi-randomized, or non-randomized controlled or crossover trials that evaluated the acute or longitudinal effects of accumulated exercise compared with a single session of energy-matched continuous exercise on PPG, postprandial insulin, and triglycerides in diabetic and non-diabetic adults. Same-day and second-morning effects were assessed separately for acute intervention studies. Subgroup analyses were conducted based on the number of exercise bouts (2–3 bouts or frequent brief bouts (e.g., 1–6 min) throughout the day at 20–60-min intervals (known as physical activity [PA] breaks, ≥ 5 bouts)), exercise intensity, and populations. Risk of bias was assessed using the revised Cochrane risk-of-bias tool for randomized trials. Pooled effects were reported as standardized mean differences (SMD) and 95% CI using a random effects model. Results Twenty-seven studies (635 participants) were included. A significant difference was found for same-day PPG control, which favored accumulated exercise over one bout of energy-matched continuous exercise (SMD − 0.36 [95%CI: (− 0.56, − 0.17)], P = 0.0002, I2 = 1%), specifically in accumulated exercise with PA breaks (SMD − 0.36 [95%CI: (− 0.64, − 0.08)], P = 0.01, I2 = 30%), low-moderate intensity exercise (SMD − 0.38 [(95%CI: (− 0.59, − 0.17)], P = 0.0005, I2 = 0%), and in non-diabetic populations (SMD − 0.36 [95%CI: (− 0.62, − 0.10)], P = 0.007, I2 = 16%). No differences were found for same-day postprandial insulin and triglycerides, and second-morning effects (postprandial or fasting glucose, insulin, and triglycerides) between different exercise patterns. Conclusion Compared with one session of continuous exercise, accumulated exercise—specifically in subgroups of PA breaks, low-moderate intensity exercises—produced greater acute effects on same-day PPG control for non-diabetic adults. There were no differences between continuous and accumulated patterns of exercise in terms of same-day postprandial insulin and triglycerides, and second-morning effects on all previously mentioned markers. The findings provide additional PA options for PPG control for individuals with limited time or exercise capacity to engage in PA in one session. Registration: PROSPERO (identification code: CRD42021251325).

show abstract

Section: Discussionmentioning

confidence: 99%

The Effects of Accumulated Versus Continuous Exercise on Postprandial Glycemia, Insulin, and Triglycerides in Adults with or Without Diabetes: A Systematic Review and Meta-Analysis

Zhang

Zheng

et al. 2022

Sports Med - Open

Self Cite

View full text Add to dashboard Cite

show abstract

“…Results from original studies following (or not included in) the aforementioned meta-analyses are similar. Breaking up prolonged sitting with standing, walking, chair squats, resistance exercise (RE) or stair climbing in young healthy individuals [104][105][106], individuals with increased cardiometabolic risk [106][107][108][109][110] and older women [109] on the day of the test meals did not affect PPL.…”

Section: Exercise Performed On the Day Of A High-or Moderate-fat Mealmentioning

confidence: 99%

“…This has also been found with cycling sprints spread over the day 44 . When short bouts of exercise are performed on the day of the meal(s), most studies find no effect on PPL 104 105 106 107 108 109 110 , whereas some find a lowering effect 26 63 64 .…”

Section: Introductionmentioning

confidence: 99%

Exercise to Lower Postprandial Lipemia: Why, When, What and How

Petridou

Mougios

2022

Int J Sports Med

View full text Add to dashboard Cite

We review recent findings on the ability of exercise to lower postprandial lipemia (PPL). Specifically, we answer why exercise is important in lowering PPL, when it is most effective to exercise to achieve this, what the preferred exercise is and how exercise reduces PPL. Most findings confirm the power of exercise to lower PPL, which is an independent risk factor for cardiovascular disease. Exercise is most effective when performed on the day preceding a high- or moderate-fat meal. This effect lasts up to approximately two days; therefore, one should exercise frequently to maintain this benefit. However, the time of exercise relative to a meal is not that important in real-life conditions, since one consumes several meals during the day; thus, an exercise bout will inevitably exert its lowering effect on PPL in one or more of the subsequent meals. Although moderate-intensity continuous exercise, high-intensity intermittent exercise (HIIE), resistance exercise and accumulation of short bouts of exercise throughout the day are all effective in lowering PPL, submaximal, high-volume interval exercise seems to be superior, provided it is tolerable. Finally, exercise reduces PPL by both lowering the rate of appearance and increasing the clearance of triacylglycerol-rich lipoproteins from the circulation.

show abstract

“…Observational 8,9 and experimental [10][11][12] studies have demonstrated that interruptions in sitting time can improve glucose metabolism. Compelling evidence suggests that interrupting sitting time with the brief bouts of standing 13 or light-intensity physical activity 14 is sufficient to improve glycemic control in elderly individuals and those with type 2 diabetes.…”

Section: Introductionmentioning

confidence: 99%

Enhanced muscle activity during interrupted sitting improves glycemic control in overweight and obese men

Gao,

Li,

Finni

et al. 2024

Scandinavian Med Sci Sports

View full text Add to dashboard Cite

The efficacy of interrupting prolonged sitting may be influenced by muscle activity patterns. This study examined the effects of interrupting prolonged sitting time with different muscle activity patterns on continuously monitored postprandial glycemic response. Eighteen overweight and obese men (21.0 ± 1.2 years; 28.8 ± 2.2 kg/m2) participated in this randomized four‐arm crossover study, including uninterrupted sitting for 8.5 h (SIT) and interruptions in sitting with matched energy expenditure and duration but varying muscle activity: 30‐min walking at 4 km/h (ONE), sitting with 3‐min walking at 4 km/h (WALK) or squatting (SQUAT) every 45 min for 10 times. Net incremental area under the curve (netiAUC) for glucose was compared between conditions. Quadriceps, hamstring, and gluteal muscles electromyogram (EMG) patterns including averaged muscle EMG amplitude (aEMG) and EMG activity duration were used to predict the effects on glucose netiAUC. Compared with SIT (10.2 mmol/L/h [95%CI 6.3 to 11.7]), glucose netiAUC was lower during sitting interrupted with any countermeasure (ONE 9.2 mmol/L/h [8.0 to 10.4], WALK 7.9 mmol/L/h [6.4 to 9.3], and SQUAT 7.9 mmol/L/h [6.4 to 9.3], all p < 0.05). Furthermore, WALK and SQUAT resulted in a lower glucose netiAUC compared with ONE (both p < 0.05). Only increased aEMG in quadriceps (−0.383 mmol/L/h [−0.581 to −0.184], p < 0.001) and gluteal muscles (−0.322 mmol/L/h [−0.593 to −0.051], p = 0.022) was associated with a reduction in postprandial glycemic response. Collectively, short, frequent walking or squatting breaks effectively enhance glycemic control in overweight and obese men compared to a single bout of walking within prolonged sitting. These superior benefits seem to be associated with increased muscle activity intensity in the targeted muscle groups during frequent transitions from sitting to activity.

show abstract

Interrupting Prolonged Sitting Reduces Postprandial Glucose Concentration in Young Men With Central Obesity

Cited by 5 publications

References 33 publications

The Effects of Accumulated Versus Continuous Exercise on Postprandial Glycemia, Insulin, and Triglycerides in Adults with or Without Diabetes: A Systematic Review and Meta-Analysis

The Effects of Accumulated Versus Continuous Exercise on Postprandial Glycemia, Insulin, and Triglycerides in Adults with or Without Diabetes: A Systematic Review and Meta-Analysis

Exercise to Lower Postprandial Lipemia: Why, When, What and How

Enhanced muscle activity during interrupted sitting improves glycemic control in overweight and obese men

Contact Info

Product

Resources

About