Intersex and alterations in reproductive development of a cichlid, Tilapia guineensis , from a municipal domestic water supply lake (Eleyele) in Southwestern Nigeria

Adeogun, Aina O.; Ibor, Oju R.; Adeduntan, Sherifat D.; Arukwe, Augustine

doi:10.1016/j.scitotenv.2015.09.061

Cited by 42 publications

(17 citation statements)

References 76 publications

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“…However, it has also been reported that E2 can stimulate the production of reactive oxygen species (ROS), which results in oxidative damage to aquatic organisms (Guti errez-G omez et al, 2016). Biomarkers for monitoring environmental health are informative tools for detecting exposure and effects of chemical pollutants, including EDCs (Adeogun et al, 2016). Among the techniques to detect genotoxic effects, the comet assay detects DNA single-strand breaks (strand breaks and incomplete excision repair sites), alkali-labile sites and cross-linking, with the single-cell approach typical of cytogenetic assays (Kumaravel and Jha, 2006;Kumaravel et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

17β-Estradiol induces cyto-genotoxicity on blood cells of common carp (Cyprinus carpio)

et al. 2018

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17β-Estradiol, a natural hormone present at high concentrations in aquatic ecosystems, affects and modifies endocrine function in animals. In recent years research workers have expressed concern over its potential effects on aquatic organisms; however, little is known about its capacity to induce genetic damage or the pro-apoptotic effects of such damage on fish. Therefore, this study aimed to evaluate 17β-estradiol-induced cyto-genotoxicity in blood cells of the common carp Cyprinus carpio exposed to different concentrations (1 ng, 1 μg and 1 mg L). Peripheral blood samples were collected and evaluated by comet assay, micronucleus test, determination of caspase-3 activity and TUNEL assay at 12, 24, 48, 72 and 96 h of exposure. Increases in frequency of micronuclei, TUNEL-positive cells and caspase-3 activity were observed, particularly at the highest concentration. In contrast, the comet assay detected significant increases at 24 and 96 h with the 1 μg and 1 ng L concentrations respectively. The set of assays used in the present study constitutes a reliable early warning biomarker for evaluating the toxicity induced by this type of emerging contaminants on aquatic species.

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Section: Discussionmentioning

confidence: 99%

17β-Estradiol induces cyto-genotoxicity on blood cells of common carp (Cyprinus carpio)

et al. 2018

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“…Generally, VTG levels in male fish are considered a biomarker for identifying exposure to EEs (Sumper & Jobling, 1995). Elevation of VTG synthesis and gene expression in the liver have been observed in males affected by EEs or other endocrine‐disrupting chemicals in wild fish, such as the cichlid, Tilapia guineensis (Adeogun, Ibor, Adeduntan, & Arukwe, ), and the fathead minnow, Pimephales promelas (Jasinska et al, ). In particular, a significant influence on VTG synthesis and gene expression by a high concentration of EEs via exposure or injection have been demonstrated in the male sand goby, Pomatoschistus minutus (Robinson et al, ), and the crucian carp, Carassius auratus (Huang et al, ), among others.…”

Section: Discussionmentioning

confidence: 99%

“…Elevation of VTG synthesis and gene expression in the liver have been observed in males affected by EEs or other endocrine-disrupting chemicals in wild fish, such as the cichlid, Tilapia guineensis (Adeogun, Ibor, Adeduntan, & Arukwe, 2016), and the fathead minnow, Pimephales promelas (Jasinska et al, 2015). In particular, a significant influence on VTG synthesis and gene expression by a high concentration of EEs via exposure or injection have been demonstrated in the male sand goby,…”

Section: Discussionmentioning

confidence: 99%

Standardization of plasma vitellogenin level for surveying environmental estrogen pollution using the Japanese common goby Acanthogobius flavimanus

Song

Nagae

Soyano

2018

J of Applied Toxicology

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Field surveys of the impact of environmental estrogen (EE) pollution in aquatic wildlife have been conducted using vitellogenin (VTG) as a biomarker to evaluate the influence of EE. However, a standard baseline of VTG level that can be used to evaluate EE pollution has not been fully determined. To the best of our knowledge, the present study is the first to determine the standard baseline VTG level for evaluating the biological effects of EE pollution using the Japanese common goby (Acanthogobius flavimanus) as the target model fish. Plasma VTG and estradiol-17β (E ) levels associated with the reproductive cycle of wild goby inhabiting an unpolluted environment were measured. Mean plasma VTG and E levels exhibited similar changes, increasing in the yolk vesicle stage and peaking in the tertiary yolk stage in females. However, plasma VTG and E levels showed no significant changes in males, remaining at low levels throughout the reproductive cycle. The highest VTG levels in females and males were 1.6 mg ml and 124.87 ng ml , respectively. These results indicate that the baseline level (normal level) in males was approximately 130 ng ml at most. We concluded that the threshold between normal and abnormal levels with a 10% risk rate was 150 ng ml in the wild male goby. Plasma VTG levels in males captured from Nagasaki Harbor were higher than the threshold in each reproductive developmental stage, indicating the possibility of EE pollution at this site. The biological standard baseline for VTG established in this study is useful for assessing EE pollution in natural waters.

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“…Pollutant effects may vary depending on their types and source. For instance, while heavy metals, dyes, and some other organic pollutants have been identified as carcinogens, hormones, pharmaceuticals, and cosmetics and personal care product wastes are known as endocrine disruptive chemicals [7]. These pollutants, which enter into the water body through various channel but predominantly anthropogenic, have become a great concern to environmentalists due to various hazard they pose on the environment.…”

Section: Effects and Challengesmentioning

confidence: 99%

Water Pollution: Effects, Prevention, and Climatic Impact

Adejumoke¹,

Babatunde²,

AbimbolaP.³

et al. 2018

Water Challenges of an Urbanizing World

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The stress on our water environment as a result of increased industrialization, which aids urbanization, is becoming very high thus reducing the availability of clean water. Polluted water is of great concern to the aquatic organism, plants, humans, and climate and indeed alters the ecosystem. The preservation of our water environment, which is embedded in sustainable development, must be well driven by all sectors. While effective wastewater treatment has the tendency of salvaging the water environment, integration of environmental policies into the actor firms core objectives coupled with continuous periodical enlightenment on the present and future consequences of environmental/ water pollution will greatly assist in conserving the water environment.

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Intersex and alterations in reproductive development of a cichlid, Tilapia guineensis , from a municipal domestic water supply lake (Eleyele) in Southwestern Nigeria

Cited by 42 publications

References 76 publications

17β-Estradiol induces cyto-genotoxicity on blood cells of common carp (Cyprinus carpio)

17β-Estradiol induces cyto-genotoxicity on blood cells of common carp (Cyprinus carpio)

Standardization of plasma vitellogenin level for surveying environmental estrogen pollution using the Japanese common goby Acanthogobius flavimanus

Water Pollution: Effects, Prevention, and Climatic Impact

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