Interspecies Interactions within the Host: the Social Network of Group B<i>Streptococcus</i>

Mejia, Marlyd E.; Robertson, Clare M; Patras, Kathryn A.

doi:10.1128/iai.00440-22

Cited by 10 publications

(3 citation statements)

References 292 publications

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“… 53 The ability of GBS to translocate to MLN following antibiotic treatment highlights the influence of the microbial landscape on the ability of GBS to maintain a niche and disseminate from the intestine and may promote its continued presence and potential pathogenicity. 54 Lactobacillus strains have antagonistic effects on GBS colonization, 55 and maternal probiotic interventions utilizing Lactobacillus reduced GBS colonization postpartum. 56 Further investigation is necessary to explore the potential competition and other factors microbes face when accessing GAPs for lumenal translocation.…”

Section: Discussionmentioning

confidence: 99%

Neonatal intestinal colonization of Streptococcus agalactiae and the multiple modes of protection limiting translocation

Greenfield,

Harlow,

Witt

et al. 2024

Gut Microbes

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Streptococcus agalactiae , also known as Group B Streptococcus (GBS), is a predominant pathogen of neonatal sepsis, commonly associated with early-onset neonatal sepsis. GBS has also been associated with cases of late-onset sepsis potentially originating from the intestine. Previous findings have shown GBS can colonize the infant intestinal tract as part of the neonatal microbiota. To better understand GBS colonization dynamics in the neonatal intestine, we collected stool and milk samples from prematurely born neonates for identification of potential pathogens in the neonatal intestinal microbiota. GBS was present in approximately 10% of the cohort, and this colonization was not associated with maternal GBS status, delivery route, or gestational weight. Interestingly, we observed the relative abundance of GBS in the infant stool negatively correlated with maternal IgA concentration in matched maternal milk samples. Using a preclinical murine model of GBS infection, we report that both vertical transmission and direct oral introduction resulted in intestinal colonization of GBS; however, translocation beyond the intestine was limited. Finally, vaccination of dams prior to breeding induced strong immunoglobulin responses, including IgA responses, which were associated with reduced mortality and GBS intestinal colonization. Taken together, we show that maternal IgA may contribute to infant immunity by limiting the colonization of GBS in the intestine.

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Section: Discussionmentioning

confidence: 99%

Neonatal intestinal colonization of Streptococcus agalactiae and the multiple modes of protection limiting translocation

Greenfield,

Harlow,

Witt

et al. 2024

Gut Microbes

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“…placental, epithelial, and blood–brain barriers), and resistance to immune defences (Maisey et al 2008a ). Additionally, interactions between GBS and other resident microbes at mucosal surfaces, including in the FRT may be synergistic or antagonistic, though their influence on pathogenesis is unknown (Mejia et al 2023 ). In the FRT, GBS must overcome local immune responses including the recruitment and activation of immune cells to succeed in persistent colonization (Brokaw et al 2021 ).…”

Section: Gbs Disease Pathogenesis and Virulence Factorsmentioning

confidence: 99%

An opportunistic pathogen under stress: how Group B Streptococcus responds to cytotoxic reactive species and conditions of metal ion imbalance to survive

Goh,

Desai,

Thapa

et al. 2024

FEMS Microbiology Reviews

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Group B Streptococcus (GBS; also known as Streptococcus agalactiae) is an opportunistic bacterial pathogen that causes sepsis, meningitis, pneumonia and skin and soft tissue infections in neonates and healthy or immunocompromised adults. GBS is well-adapted to survive in humans due to a plethora of virulence mechanisms that afford responses to support bacterial survival in dynamic host environments. These mechanisms and responses include counteraction of cell death from exposure to excess metal ions that can cause mismetallation and cytotoxicity, and strategies to combat molecules such as reactive oxygen and nitrogen species that are generated as part of innate host defence. Cytotoxicity from reactive molecules can stem from damage to proteins, DNA, and membrane lipids, potentially leading to bacterial cell death inside phagocytic cells or within extracellular spaces within the host. Deciphering the ways in which GBS responds to the stress of cytotoxic reactive molecules within the host will benefit the development of novel therapeutic and preventative strategies to manage the burden of GBS disease. This review summarises knowledge of GBS carriage in humans and the mechanisms used by the bacteria to circumvent killing by these important elements of host immune defence: oxidative stress, nitrosative stress, and stress from metal ion intoxication/mismetallation.

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“…agalactiae, also known as Group B Streptococcus (GBS), is a pathobiont that colonizes the vaginal tract and is associated with pregnancy complications including chorioamnionitis, preterm premature rupture of membranes, and preterm labor, as well as invasive infections in the newborn [49,50]. Many population studies show a significant association between GBS and C. albicans vaginal carriage [51][52][53][54][55]. C. albicans has been shown to increase GBS adherence to vaginal epithelial cells due to co-association mediated by the fungal agglutinin-like sequence protein 3 (Als3) and GBS adhesins in the antigen I/II (AgI/II) protein family [56].…”

Section: How Do Pathogenic Bacteria Interact With Candida During Infe...mentioning

confidence: 99%

Impact of interkingdom microbial interactions in the vaginal tract

Cohen,

Ost,

Doran

2024

PLoS Pathog

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Interspecies Interactions within the Host: the Social Network of Group BStreptococcus

Abstract: Group B Streptococcus (GBS) is a pervasive neonatal pathogen accounting for a combined half a million deaths and stillbirths annually. The most common source of fetal or neonatal GBS exposure is the maternal microbiota.

Cited by 10 publications

References 292 publications

Neonatal intestinal colonization of Streptococcus agalactiae and the multiple modes of protection limiting translocation

Neonatal intestinal colonization of Streptococcus agalactiae and the multiple modes of protection limiting translocation

An opportunistic pathogen under stress: how Group B Streptococcus responds to cytotoxic reactive species and conditions of metal ion imbalance to survive

Impact of interkingdom microbial interactions in the vaginal tract

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