2022
DOI: 10.3389/fcimb.2022.900608
|View full text |Cite
|
Sign up to set email alerts
|

Interspecies Isobaric Labeling-Based Quantitative Proteomics Reveals Protein Changes in the Ovary of Aedes aegypti Coinfected With ZIKV and Wolbachia

Abstract: Zika is a vector-borne disease caused by an arbovirus (ZIKV) and overwhelmingly transmitted by Ae. aegypti. This disease is linked to adverse fetal outcomes, mostly microcephaly in newborns, and other clinical aspects such as acute febrile illness and neurologic complications, for example, Guillain-Barré syndrome. One of the most promising strategies to mitigate arbovirus transmission involves releasing Ae. aegypti mosquitoes carrying the maternally inherited endosymbiont bacteria Wolbachia pipientis. The pres… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
4
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
3
1

Relationship

1
3

Authors

Journals

citations
Cited by 4 publications
(5 citation statements)
references
References 122 publications
1
4
0
Order By: Relevance
“…Wolbachia interactions with the juvenile hormone biosynthetic pathway have been previously reported [94]. Particularly, a proteomic assay on transfected A. aegypti ovaries showed downregulation of farnesol dehydrogenase and mevalonate kinase, two enzymes in the JHIII biosynthetic pathway [96]. However, to the best of our knowledge, our study is the first showing Wolbachia ’s consistent upregulation of the putative FAMeT codifying AAEL004667 in A. aegypti .…”
Section: Resultssupporting
confidence: 54%
See 2 more Smart Citations
“…Wolbachia interactions with the juvenile hormone biosynthetic pathway have been previously reported [94]. Particularly, a proteomic assay on transfected A. aegypti ovaries showed downregulation of farnesol dehydrogenase and mevalonate kinase, two enzymes in the JHIII biosynthetic pathway [96]. However, to the best of our knowledge, our study is the first showing Wolbachia ’s consistent upregulation of the putative FAMeT codifying AAEL004667 in A. aegypti .…”
Section: Resultssupporting
confidence: 54%
“…aegypti ovaries showed downregulation of farnesol dehydrogenase and mevalonate kinase, two enzymes in the JHIII biosynthetic pathway [96] . However, to the best of our knowledge, our study is the first showing Wolbachia 's consistent upregulation of the putative FAMeT codifying AAEL004667 in A. aegypti .…”
Section: Liu Et Al (2014)mentioning
confidence: 99%
See 1 more Smart Citation
“…Aedes aegypti females when infected with DENV or ZIKV have a reduction in life-history traits such as survivorship, fecundity, and fertility [ 61 , 62 , 63 , 64 , 65 ]. On a molecular and biochemical level, there are abundant data using gene expression, transcriptomics, and proteomics approaches revealing that most of the altered genes are involved in metabolic processes, cellular processes, and proteolysis [ 58 , 66 , 67 , 68 ]. Thus, most likely the NIR detects those physiological changes caused by infection and then is able to differentiate between infected and uninfected individuals.…”
Section: Discussionmentioning
confidence: 99%
“…ZIKV transmission can be vector-borne or non-vector-borne 1 . Vector-borne transmission occurs when the virus infects the host through mosquito bites 36 . This explains the sylvatic transmission cycle, where non-human primates and endemic mosquitoes (enzootic vectors) are involved, as well as human-mosquito-human transmission in urban and suburban regions 1,37 .…”
Section: Zikvmentioning
confidence: 99%