Interspecies Transmission, Genetic Diversity, and Evolutionary Dynamics of Pseudorabies Virus

He, Wanting; Auclert, Lisa Zoé; Zhai, Xiaofeng; Wong, Gary; Zhang, Cheng; Zhu, Henan; Xing, Gang; Wang, Shilei; He, Wei; Li, Kemang; Wang, Liang; Han, Guan-Zhu; Veit, Michael; Zhou, Jiyong; Su, Shuo

doi:10.1093/infdis/jiy731

Cited by 121 publications

(107 citation statements)

References 37 publications

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“…Therefore, further investigations still need to clarify the specific functions of these non-synonymous substitutions. Cross-host transmission frequently occurred in animal virus, such as porcine circovirus (PCV3) [51], and pseudorabies virus (PRV) [52] in DNA virus, influenza A viruses (IAVs) [53][54][55] and coronavirus [7,[56][57][58] in RNA virus. One of the most notable is coronavirus.…”

Section: Discussionmentioning

confidence: 99%

Etiology and genetic evolution of canine coronavirus circulating in five provinces of China, during 2018–2019

Zhang

Liang

et al. 2020

Microbial Pathogenesis

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A B S T R A C TAs the outbreaks of COVID-19 in worldwide, coronavirus has once again caught the attention of people. Canine coronavirus is widespread among dog population, and sometimes causes even fatal cases. Here, to characterize the prevalence and evolution of current circulating canine coronavirus (CCoV) strains in China, we collected 213 fecal samples from diarrheic pet dogs between 2018 and 2019. Of the 213 samples, we found 51 (23.94%) were positive for CCoV. Co-infection with canine parvovirus (CPV), canine astrovirus (CaAstV), canine kobuvirus (CaKV), Torque teno canis virus (TTCaV) were ubiquitous existed. Mixed infection of different CCoV subtypes exists extensively. Considering the limited sequences data in recent years, we sequenced 7 nearly complete genomes and 10 complete spike gene. Phylogenetic analysis of spike gene revealed a new subtype CCoV-II Variant and CCoV-IIa was the most prevalent subtype currently circulating. Moreover, we identified strain B906_ZJ_2019 shared 93.24% nucleotide identifies with previous strain A76, and both of them clustered with CCoV-II Variant, which were not well clustered with the known subtypes. Recombination analysis of B906_ZJ_2019 indicated that strain B906_ZJ_2019 may a recombinant variant between CCoV-I and CCoV-II, which is consistent with strain A76. Furthermore, amino acid variations widely existed among current CCoV-IIa strains circulating in China and the classic CCoV-IIa strains, in spite of the unknown functions.In a word, we report a useful information as to the etiology and evolution of canine coronavirus in China based on the available sequences, which is urgent for the devise of future effective disease prevention and control strategies.

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Section: Discussionmentioning

confidence: 99%

Etiology and genetic evolution of canine coronavirus circulating in five provinces of China, during 2018–2019

Zhang

Liang

et al. 2020

Microbial Pathogenesis

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“…Its UL44 gene encodes glycoprotein C (gC), which plays a role in virus attachment to cell receptors and is one of the major targets for the host's immune system [2]. The partial sequencing of the gC-encoding gene, which is one of the most variable regions of the genome and has the largest number of reported sequences [4,5], showed that whatever their host species, PRV strains can be classified as genotype I or genotype II, mostly depending on their geographical location, i.e., respectively, Europe/America or Asia [6][7][8]. Within genotype I, PRV strains can be divided into two clades: clade A, which contains PRV strains from Europe and America, and clade B with strains only originating from Western Europe [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Genetic Diversity among Pseudorabies Viruses Isolated from Dogs in France from 2006 to 2018

et al. 2019

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Pseudorabies (PR), also known as Aujeszky’s disease, is an economically important disease for the pig industry. It has been eradicated in domestic pigs in many European countries, including France, but its causative agent—Suid Herpesvirus 1—is still circulating in wild boars. The risk of endemic PR in wild fauna lies in reintroducing the virus among domestic pigs and transmitting it to other mammals, especially hunting dogs for which the disease is rapidly fatal. As such infections are regularly reported in France, this study genetically characterized canine PR virus strains in the country to obtain information on their diversity and evolution. Partial sequencing of the glycoprotein C-encoding gene from 55 virus strains isolated from dogs between 2006 and 2018 showed that 14 strains belonged to genotype I-clade A and another 38 to genotype I-clade B, two clades usually reported in Western Europe. More surprisingly, three strains were found to belong to genotype II, suggesting an Asian origin. Genotype I-clade A strains exhibited the highest diversity as five geographically segregated genogroups were identified.

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“…Markov Chain Monte Carlo (MCMC) sampling was run for 1 × 10 8 generations, with trees and posteriors sampled every 1 × 10 4 steps. Two independent runs were combined using LogCombiner (He, Auclert, et al, ). The final tree was summarized using Tree Annount software and displayed using FigTree (version 1.4.7).…”

Section: Methodsmentioning

confidence: 99%

Emergence and adaptive evolution of Nipah virus

Yan

Wang

et al. 2019

Transbound Emerg Dis

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Since its first emergence in 1998 in Malaysia, Nipah virus (NiV) has become a great threat to domestic animals and humans. Sporadic outbreaks associated with human‐to‐human transmission caused hundreds of human fatalities. Here, we collected all available NiV sequences and combined phylogenetics, molecular selection, structural biology and receptor analysis to study the emergence and adaptive evolution of NiV. NiV can be divided into two main lineages including the Bangladesh and Malaysia lineages. We formly confirmed a significant association with geography which is probably the result of long‐term evolution of NiV in local bat population. The two NiV lineages differ in many amino acids; one change in the fusion protein might be involved in its activation via binding to the G protein. We also identified adaptive and positively selected sites in many viral proteins. In the receptor‐binding G protein, we found that sites 384, 386 and especially 498 of G protein might modulate receptor‐binding affinity and thus contribute to the host jump from bats to humans via the adaption to bind the human ephrin‐B2 receptor. We also found that site 1645 in the connector domain of L was positive selected and involved in adaptive evolution; this site might add methyl groups to the cap structure present at the 5′‐end of the RNA and thus modulate its activity. This study provides insight to assist the design of early detection methods for NiV to assess its epidemic potential in humans.

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Interspecies Transmission, Genetic Diversity, and Evolutionary Dynamics of Pseudorabies Virus

Cited by 121 publications

References 37 publications

Etiology and genetic evolution of canine coronavirus circulating in five provinces of China, during 2018–2019

Etiology and genetic evolution of canine coronavirus circulating in five provinces of China, during 2018–2019

Genetic Diversity among Pseudorabies Viruses Isolated from Dogs in France from 2006 to 2018

Emergence and adaptive evolution of Nipah virus

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