Interstitial Cajal‐like cells (ICLC) in myocardial sleeves of human pulmonary veins

Gherghiceanu, Mihaela; Hinescu, Mihail Eugen; Andrei, Florin; Mandache, E; Macarie, Cezar; Faussone–Pellegrini, Maria Simonetta; Popescu, L. M.

doi:10.1111/j.1582-4934.2008.00444.x

Cited by 106 publications

(98 citation statements)

References 15 publications

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“…Multiple studies proved presence of three-dimensional spatial network of TCs in many parts of heart, such as: endocardium, myocardium, epicardium, valves and myocardial sleeves of pulmonary veins (7,31,32). However, the distribution of TCs is not homogenous in the whole heart -it is supposed that atria are more abundant in TCs than ventricles, but quantitative data is still missing (6).…”

Section: Distribution In the Heartmentioning

confidence: 99%

“…Moreover, TCs were found in myocardial sleeves of pulmonary veins, which are considered a source of ectopic beat in atrial fi brillation, so TCs may be related with its pathogenesis (32). Another theory connected with putative origins of atrial fi brillation is isolated atrial amyloidosis existence, but it still has not been established if this condition is a cause or a consequence of atrial fi brillation.…”

Section: Role Of Cardiac Tcs In Pathological Conditionsmentioning

confidence: 99%

“…Nevertheless, there is a strong association between the presence of amyloidosis in atrial tissue and TCs, as thanks to their long extensions, they surround and gather amyloid fi brils. Based on those fi ndings, it is supposed that TCs are involved in amyloid deposits formation in isolated atrial amyloidosis (32).…”

Section: Role Of Cardiac Tcs In Pathological Conditionsmentioning

confidence: 99%

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A comprehensive guide to telocytes and their great potential in cardiovascular system

Kucybała¹,

Janas²,

Ciuk³

et al. 2017

BLL

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Telocytes, a recently discovered type of interstitial cells, have a very distinctive morphology -the small cell body with long extensions, named telopodes. In our review, apart from introducing general aspects of telocytes, we focus on properties, functions and future potential of those cells in cardiovascular system. However, physiological functions of telocytes in cardiovascular system are still regarded as quite enigmatic. Previous studies claim that they play a role in organogenesis and regeneration, bioelectrical signalling, mechanoelectrical coupling, anti-oxidative protection, angiogenesis and regulation of blood fl ow. As well, they are presumably connected with the presence of blood-myocardium barrier and proper organisation of extracellular matrix. Moreover, there exists a signifi cant link between the quantity of telocytes in tissue and numerous cardiovascular diseases such as: myocardial infarction, cardiomyopathies, systemic sclerosis, heart failure, atrial fi brillation, isolated atrial amyloidosis, myxomatous valve degeneration and hyperplastic consequences of vascular injury. Thanks to their unique properties, telocytes might be a breakthrough in treatment of cardiovascular diseases, as they may be effective in reversing effects of myocardial infarction. Telocytes also may play a major role in tissue engineering -they might be the key factor in creating stable and effi cient vascular network in larger synthetic tissues or organs (Tab. 1, Fig. 3, Ref. 53). Text in PDF www.elis.sk.

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Section: Distribution In the Heartmentioning

confidence: 99%

Section: Role Of Cardiac Tcs In Pathological Conditionsmentioning

confidence: 99%

Section: Role Of Cardiac Tcs In Pathological Conditionsmentioning

confidence: 99%

See 1 more Smart Citation

A comprehensive guide to telocytes and their great potential in cardiovascular system

Kucybała¹,

Janas²,

Ciuk³

et al. 2017

BLL

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“…125 These cells are present within the myocardium extensions into the pulmonary veins and could play a role in the genesis or maintenance of AF. 126 As the roles of Cajal-like cells become clearer, these may be candidates for modulation in ventricular fibrillation or atrial arrhythmias.…”

Section: Novel Targets For Catheter Ablationmentioning

confidence: 99%

Innovations in Clinical Cardiac Electrophysiology: Challenges and Upcoming Solutions in 2018 and Beyond

Vaidya¹,

Sugure²,

Asirvatham³

2017

J Innov Cardiac Rhythm Manage

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“…ICLCs were detected in the myocardial sleeves of the human pulmonary veins (Gherghiceanu et al, 2008;Morel et al, 2008), especially in patients with atrial fibrillation, and were presumed to act as pacemaker cells in these veins (Morel et al, 2008).…”

mentioning

confidence: 99%

Extrahepatic and Intrahepatic Human Portal Interstitial Cajal Cells

Rusu

Pop

Hostiuc³

et al. 2011

The Anatomical Record

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Portal interstitial cells of Cajal (PICCs), acting as vascular pacemakers, were previously only identified in nonhumans. Moreover, there is no evidence available about the presence of such cells within the liver. The objective of the study is to evaluate whether or not PICCs are identifiable in humans and, if they are, whether or not they are following the scaffold of portal vein (PV) branches within the liver. We obtained extrahepatic PVs and liver samples from six adult human cadavers, negative for liver disease, in accordance with ethical rules. They were stained with hematoxylin-eosin (HE) and Giemsa, and then we performed immunohistochemistry on formalin-fixed paraffin-embedded specimens for CD117/c-kit, a marker of the Cajal's cells. Immune labeling was also performed for S-100 protein, desmin, glial fibrillary acidic protein (GFAP), neurofilaments, a-smooth muscle actin (a-SMA), and CD34. c-kit-Positive PICCs were identified within the extrahepatic PV, in portal spaces, and septa. On adjacent sections, these PICCs were negative for all the other antibodies used. In conclusion, our study confirms the presence of extrahepatic PICCs on humans, which may act as a possible intrinsic pacemaker in the human PV. However, the intrahepatic PICCs, which were evidenced here for the first time, are in need for further experimental studies to evaluate their functional role. A promising further direction of the study is the PICCs role in the idiopathic portal hypertension. Anat Rec, 294:1382Rec, 294: -1392Rec, 294: , 2011. V V C 2011 Wiley-Liss, Inc.

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Interstitial Cajal‐like cells (ICLC) in myocardial sleeves of human pulmonary veins

Cited by 106 publications

References 15 publications

A comprehensive guide to telocytes and their great potential in cardiovascular system

A comprehensive guide to telocytes and their great potential in cardiovascular system

Innovations in Clinical Cardiac Electrophysiology: Challenges and Upcoming Solutions in 2018 and Beyond

Extrahepatic and Intrahepatic Human Portal Interstitial Cajal Cells

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