Interstitial Cystitis in Chronic Granulomatous Disease

Kontras, Stella B.; Bodenbender, Joann G.; Mcclaye, Charles R.; Smith, JA

doi:10.1016/s0022-5347(17)61580-5

Cited by 36 publications

(13 citation statements)

References 6 publications

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“…O ur two patients presented with localized areas of bladder edem a that mimicked solid tumors. W ith the exception of two patients who re ceived chronic steroid therapy (3,4), inflammation was confined to the bladder. W e found ultrasonogra phy to be particularly helpful in defining the extent of bladder edema, allowing an objective assessment of re sponse to therapy.…”

Section: Discussionmentioning

confidence: 93%

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Recurrent Cystitis and Bladder Mass in Two Adults with Chronic Granulomatous Disease

Southwick

Meer²

1988

Ann Intern Med

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Section: Discussionmentioning

confidence: 93%

“…If sym ptom s and bladder edem a fail to respond to antibiotic therapy, steroids may be added. However, steroids should be administered cautiously because they have been associated with spread of the inflam m atory process to the upper urinary tract in at least two patients (3,4).…”

Section: Discussionmentioning

confidence: 99%

Recurrent Cystitis and Bladder Mass in Two Adults with Chronic Granulomatous Disease

Southwick

Meer²

1988

Ann Intern Med

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“…Some reports, including our experience, demonstrate that genitourinary involvement in CGD may also be represented by EC. EC is a rare pediatric inflammatory disorder of the bladder characterized by extensive eosinophilic infiltration of all Table 1 Clinical, diagnostic, and therapeutic findings of eosinophilic cystitis in patients with chronic granulomatus disease (CGD) Kontras et al (1971) [13] Bauer et al (1991) [14] R e d m a n e t a l . WBC white blood cells, E eosinophils, N neutrophils layers of the bladder wall [4].…”

Section: Discussion and Review Of Literaturementioning

confidence: 99%

“…However, spontaneous remission has been frequently seen in children, suggesting observation only [5-7, 9, 11, 12]. We carried out a retrospective literature review of reported CGD patients who developed EC in order to assess clinical manifestations, diagnostic tools, therapeutic strategies and outcomes (Table 1) [11,[13][14][15].…”

Section: Discussion and Review Of Literaturementioning

confidence: 99%

How should eosinophilic cystitis be treated in patients with chronic granulomatous disease?

et al. 2014

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Background Chronic granulomatous disease (CGD) is a primary immunodeficiency resulting from the absence or malfunction of oxidative mechanism in phagocytic cells. The disease is due to a mutation in one of four genes that encode subunits of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. Affected patients experience severe infections and granuloma formation due to exuberant inflammatory responses. Some evidence suggests that eosinophilic cystitis (EC) is included in the spectrum of inflammatory manifestations. EC is an inflammatory disease, rare in childhood, which may require different, nonstandardized therapeutic approaches, ranging from antihistamines to cyclosporine.Case-Diagnosis/Treatment Herein we describe the cases of two CGD patients with CGD who experienced EC during hospitalization for a severe infection. Conclusions EC in immunocompetent children seems to have a self-limiting course, unlike in CGD patients, in whom it presents a prolonged and recurrent course. We focus on the effective therapy administered to our patients with CGD and review the corresponding literature.

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“…Multiple organ systems may be involved, including the skin, gastrointestinal tract, respiratory tract, lymph nodes, liver, spleen, and bones. There are few reports of genitourinary tract involvement [2][3][4][5][6].…”

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confidence: 99%