Interstitial del(14)(q) involving IGH: a novel recurrent aberration in B-NHL

Pospíšilová, Helena; Baens, Mathijs; Michaux, Lucienne; Stul, Michel; Hummelen, Paul Van; Loo, Peter Van; Vermeesch, Joris Robert; Jarošová, Marie; Zemanová, Zuzana; Michalova, Kyra; Berghe, Ivo Van Den; Alexander, H. Denis; Hagemeijer, Anne; Vandenberghe, Peter; Cools, Jan; Wolf‐Peeters, Chris De; Marynen, Peter; Włodarska, Iwona

doi:10.1038/sj.leu.2404739

Cited by 35 publications

(57 citation statements)

References 6 publications

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“…In the present series, no case with 14q deletion was associated with trisomy 12, as in a previous report. 33 Our findings suggest that 14q deletions are recurrent but infrequent in SMZL.…”

Section: Cytogenetic Findingsmentioning

confidence: 57%

“…Furthermore, in all cases of the present series carrying t(14;19)(q32;q13), this aberration was associated with del(7q) and a complex karyotype, in keeping with a previous report. 30 Eight cases exhibited the del14q abnormality, which has been reported in low-grade B-cell malignancies, particularly CLL, 33 and often associated with trisomy 12 and unmutated IGHV genes. In the present series, no case with 14q deletion was associated with trisomy 12, as in a previous report.…”

Section: Cytogenetic Findingsmentioning

confidence: 99%

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Cytogenetic aberrations and their prognostic value in a series of 330 splenic marginal zone B-cell lymphomas: a multicenter study of the Splenic B-Cell Lymphoma Group

Salido

Baró

Oscier

et al. 2010

Blood

173

149

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We conducted a retrospective collaborative study to cytogenetically characterize splenic marginal zone lymphoma (SMZL) and ascertain the prognostic value of chromosomal aberrations. Of 330 cases, 72% displayed an aberrant karyotype, 53% were complex, and 29% had a single aberration. The predominant aberrations were gains of 3/3q and 12q, deletions of 7q and 6q and translocations involving 8q/1q/14q. CD5 expression was detected in 39 of 158 cases (25%). The cytogenetic makeup of the CD5 ؉ group differed significantly from that of the CD5 ؊ group. Cases with unmutated IGHV were significantly associated with deletions of 7q and TP53. A strong association was noted between usage of the IGVH1-2 and deletion 7q, 14q alterations, and abnormal karyotype. On univariate analysis, patients with more than or equal to 2 aberrations, 14q alterations, and TP53 deletions had the shortest survival; 7q deletion did not affect survival. On multivariate analysis, cytogenetic aberrations did not retain prognostic significance; the parameters negatively affecting survival were hemoglobin and age. In conclusion, the cytogenetic profile of SMZL is distinct from other B-cell lymphomas. Complexity of the karyotype, 14q aberrations, and TP53 deletions are poor prognostic indicators and may be considered together with other clinicobiologic parameters to ascertain the prognosis of SMZL. (Blood. 2010;

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“…In the present series, no case with 14q deletion was associated with trisomy 12, as in a previous report. 33 Our findings suggest that 14q deletions are recurrent but infrequent in SMZL.…”

Section: Cytogenetic Findingsmentioning

confidence: 57%

Section: Cytogenetic Findingsmentioning

confidence: 99%

Cytogenetic aberrations and their prognostic value in a series of 330 splenic marginal zone B-cell lymphomas: a multicenter study of the Splenic B-Cell Lymphoma Group

Salido

Baró

Oscier

et al. 2010

Blood

173

149

View full text Add to dashboard Cite

show abstract

“…1,2 The break points of this deletion are located in the immunoglobulin heavy chain (IGH)-locus in 14q32.33 and in a region in 14q24.1 containing the ZFP36L1 gene ( 1 and our own unpublished observations). Activation of a candidate oncogene centromeric of the deletion break point in 14q24.1 through juxtaposition to the IGH locus, yet could not be unambiguously shown.…”

mentioning

confidence: 99%

“…Activation of a candidate oncogene centromeric of the deletion break point in 14q24.1 through juxtaposition to the IGH locus, yet could not be unambiguously shown. 1 An alternative hypothesis is that the deletion might inactivate a tumor suppressor gene.…”

mentioning

confidence: 99%

Biallelic inactivation of TRAF3 in a subset of B-cell lymphomas with interstitial del(14)(q24.1q32.33)

et al. 2009

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“…Several other recurrent genomic aberrations have been described in CLL, such as del(6q), del(14)(q24.1q32.33) involving IGH (Pospisilova et al, 2007), t(1;6)(p35;p25) involving MUM1/IRF4 (Michaux et al, 2005), total or partial trisomy 3, trisomy 8, trisomy 18 and 19 and changes leading to gains of 2p24-25, 3q26-27, and 8q24. These aberrations are rare in CLL (prevalence < 5-10%).…”

Section: Other Cytogenetic Aberrationsmentioning

confidence: 99%

Genetics of Chronic Lymphocytic Leukemia: Practical Aspects and Prognostic Significance

Put¹,

Włodarska²,

Vandenberghe³

et al. 2012

Chronic Lymphocytic Leukemia

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Interstitial del(14)(q) involving IGH: a novel recurrent aberration in B-NHL

Cited by 35 publications

References 6 publications

Cytogenetic aberrations and their prognostic value in a series of 330 splenic marginal zone B-cell lymphomas: a multicenter study of the Splenic B-Cell Lymphoma Group

Cytogenetic aberrations and their prognostic value in a series of 330 splenic marginal zone B-cell lymphomas: a multicenter study of the Splenic B-Cell Lymphoma Group

Biallelic inactivation of TRAF3 in a subset of B-cell lymphomas with interstitial del(14)(q24.1q32.33)

Genetics of Chronic Lymphocytic Leukemia: Practical Aspects and Prognostic Significance

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