Interstitial Fluid and Transcapillary Fluid Balance in the Lung

Waaler, B. A.; Aarseth, P.

doi:10.1002/9780470720202.ch5

Cited by 2 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fluid balance has been studied for use in various organs such as the lung [93,94], and brain [67,73,87]. The most popular model of microvascular filtration is the Starling-Landis [48,67,69] equation, J V , and the Drake-Laine equation, J L , models lymph flow [29].…”

Section: Fluid Balance In the Interstitiummentioning

confidence: 99%

“…The terms J V and J L each rely on extended constituents such as the venous / lymphatic pressure and serum protein concentrations mentioned above; section 3.1.2 contains a more detailed discussion of these terms. Edema, resulting from an imbalance in (1.1), can arise alongside various clinical pathologies, in different organs, and may complicate treatment; examples include cirrhosis, hydrocephalus, and acute respiratory distress syndrome, among others [55,58,65,93]. Edema in the small intestine can be triggered by 1 INTRODUCTION 2 traumatic injury in addition to clinical processes, such as packing a wound, or surgical treatment [23].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

An implicit discontinuous Galerkin method for modeling acute edema and resuscitation in the small intestine

Thompson

Rivière

Knepley

2019

Mathematical Medicine and Biology: A Journal of the IMA

View full text Add to dashboard Cite

Edema, also termed oedema, is a generalized medical condition associated with an abnormal aggregation of fluid in a tissue matrix. In the intestine, excessive edema can lead to serious health complications associated with reduced motility. A $7.5\%$ solution of hypertonic saline (HS) has been hypothesized as an effective means to reduce the effects of edema following surgery or injury. However, detailed clinical edema experiments can be difficult to implement, or costly, in practice. In this manuscript we introduce an implicit in time discontinuous Galerkin method with novel adaptations for modeling edema in the 3D layered physiology of the intestine. The model improves over early work via inclusion of the tissue intrinsic storage coefficient, and the effects of Starling overestimation for high venous pressures. Validation against a recent clinical experiment in HS resuscitation of acute edema is presented; the results support the clinical hypothesis that 7.5% HS solution may be effective in the resuscitation of acute edema formation. New results include an improved view into the effects of resuscitation on the hydrostatic pressure profile of edematous rats, effects on lumenal volume attenuation, relative fluid gain and an estimation of the impacts of both acute edema and resuscitation on intestinal motility.

show abstract