Interstitial granuloma annulare triggered by Lyme disease

Hyde, Jordan; Plaza, Jose A.; Kaffenberger, Jessica

doi:10.5070/d327553618

DOJ

2021

DOI: 10.5070/d327553618

|View full text |Cite

Interstitial granuloma annulare triggered by Lyme disease

Jordan Hyde¹,

Jose A. Plaza²,

Jessica Kaffenberger

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Granuloma Annulare: A Clinical Update

Kachlik,

Kaczmarek,

Grych

et al. 2024

Curr Derm Rep

View full text Add to dashboard Cite

Purpose of Review Granuloma annulare (GA) is a benign, inflammatory granulomatous skin condition that can present as localized, disseminated, subcutaneous, perforating and a few other less prevalent subtypes. While GA may manifest as a self-limited condition, its distinctive feature of mimicking other diseases, and difficulties in distinguishing between subtypes, can add complexity to the diagnostic process. This review was conducted to evaluate the latest published studies and outline the options for GA treatment. Recent Findings Multiple treatment modalities for GA have been reported, including topical and oral treatment along with many procedures, wherefrom phototherapy remains the most well-studied option. Recently new studies have identified Th1, Th2, and JAK- STAT pathways dysregulation in GA skin lesions, and subsequently, promising effects have been reported with Th1, Th2, and JAK- STAT targeting therapy for GA. Summary There is still no gold standard for clinical management of GA. Evidence-based treatment recommendations derived from randomized control trials are scarce, since the majority of published research is confined to case reports, case series, and singular retrospective studies. Therapeutic approach may vary depending on the clinical subtype of GA, necessitating individualization based on patients preferences, possible side effects and risk-benefit ratio.

show abstract

Granuloma Annulare: A Clinical Update

Kachlik,

Kaczmarek,

Grych

et al. 2024

Curr Derm Rep

View full text Add to dashboard Cite

show abstract

Secondary Syphilis Presenting With an Interstitial Granuloma Annulare-Like Histopathologic Pattern: A Report of 2 Cases

João,

Pancsa,

Kicko

et al. 2024

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Syphilis, known as “the great mimicker,” is caused by the spirochete Treponema pallidum and is characterized by a diverse array of clinical and histopathologic presentations. In secondary cutaneous syphilis, the most consistent morphological features include a superficial and deep perivascular infiltrate containing plasma cells, varying degrees of endothelial swelling, irregular acanthosis, elongation of rete ridges, a vacuolated pattern, and the presence of plasma cells. Although serologic tests are essential for definitive diagnosis, spirochetes can sometimes be directly identified in silver-stained tissue slides or through immunohistochemistry. Granuloma annulare is a relatively common, benign, self-limiting condition with 3 main variants: conventional, subcutaneous, and interstitial, each with distinct characteristics. In this study, we report 2 cases of cutaneous secondary syphilis with a striking granulomatous reaction pattern that closely mimics the interstitial variant of granuloma annulare. Owing to the severity of the tertiary stage of syphilis, distinguishing between these 2 entities is crucial.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Interstitial granuloma annulare triggered by Lyme disease

Cited by 2 publications

References 7 publications

Granuloma Annulare: A Clinical Update

Granuloma Annulare: A Clinical Update

Secondary Syphilis Presenting With an Interstitial Granuloma Annulare-Like Histopathologic Pattern: A Report of 2 Cases

Contact Info

Product

Resources

About