Interstitial Granulomatous Dermatitis with Granuloma Annulare-Like Pattern Following Liposuction

Agarwal, Indu; Thomas, Amber; Agarwal, Mohit; Cibull, Thomas

doi:10.5999/aps.2017.44.5.470

“…Two of five patients diagnosed with GA described in our series presented the interstitial-type histology. Differentiating RGD from interstitial form of GA can be challenging when biopsy shows loosely arranged histiocytes and focal mucin deposits: in this 3 BioMed Research International setting, clinical correlation is useful to address the correct diagnosis [16].…”

Section: Discussionmentioning

confidence: 99%

Granulomatous Dermatitis and Systemic Disease: An Association to Consider

Corrà

¹

,

Quintarelli

²

,

Verdelli

³

et al. 2021

Highlights on Medicine and Medical Research Vol. 8

0

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Granuloma annulare (GA) and interstitial granulomatous dermatitis (IGD) are granulomatous dermatoses with variable clinical appearances. GA is associated with diabetes mellitus, metabolic syndrome, chronic infections, and malignancies, while two Japanese reports described unusual cases of interstitial-type GA in setting of Sjogren syndrome. IGD was associated with rheumatoid arthritis, systemic lupus erythematosus, and autoantibodies. We report a case series of six patients with GA or IGD. Half of the patients were diagnosed with Sjogren syndrome, while all of them presented ANA positivity and the majority reported arthralgia. In many cases, GA showed interstitial-type histology, arising challenges in differential diagnosis with IGD. The overlap of clinical and histological features of GA and IGD can be explained considering them as a broad disease spectrum, including also the other forms of reactive granulomatous dermatitis. These conditions should be considered as an indicator of possible systemic disorders or other immunological dyscrasias, for which patients must be screened. Sjogren syndrome may be associated to GA also in Caucasians.

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“…Two of five patients diagnosed with GA described in our series presented the interstitial-type histology. Differentiating RGD from interstitial form of GA can be challenging when biopsy shows loosely arranged histiocytes and focal mucin deposits: in this setting, clinical correlation is useful to address the correct diagnosis [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Granulomatous Dermatitis and Systemic Disease: An Association to Consider

Corrà

¹

,

Quintarelli

²

,

Verdelli

³

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

Granuloma annulare (GA) and interstitial granulomatous dermatitis (IGD) are granulomatous dermatoses with variable clinical appearances. GA is associated with diabetes mellitus, metabolic syndrome, chronic infections, and malignancies, while two Japanese reports described unusual cases of interstitial-type GA in setting of Sjogren syndrome. IGD was associated with rheumatoid arthritis, systemic lupus erythematosus, and autoantibodies. We report a case series of six patients with GA or IGD. Half of the patients were diagnosed with Sjogren syndrome, while all of them presented ANA positivity and the majority reported arthralgia. In many cases, GA showed interstitial-type histology, arising challenges in differential diagnosis with IGD. The overlap of clinical and histological features of GA and IGD can be explained considering them as a broad disease spectrum, including also the other forms of reactive granulomatous dermatitis. These conditions should be considered as an indicator of possible systemic disorders or other immunological dyscrasias, for which patients must be screened. Sjogren syndrome may be associated to GA also in Caucasians.

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