Interstitial Keratitis

Tu, Elmer Y.

doi:10.1007/978-3-030-42634-7_328

Cited by 2 publications

(1 citation statement)

References 69 publications

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“…The underlying causes of interstitial keratitis fall into 2 categories: infectious or immune-mediated. 10 HSV has typically been viewed as one of the leading cause of stromal keratitis. [11][12][13] CMV, on the other hand, has not been commonly associated with stromal keratitis, but we present 5 cases in which stromal keratitis occurred in the setting of anterior uveitis or with recurrent endotheliitis and in 1 case anterior scleritis.…”

Section: Discussionmentioning

confidence: 99%

Stromal Keratitis Associated With Cytomegalovirus Anterior Uveitis

Pisitpayat,

Mentreddy,

Pekmezci

et al. 2024

Cornea

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Purpose: Human cytomegalovirus (CMV) has commonly been reported as a cause of anterior uveitis and corneal endotheliitis. Unlike its other herpetic family members, herpes simplex virus and varicella zoster virus, involvement of the corneal stroma in CMV is uncommon. In this case series, we describe patients with CMV stromal keratitis. Methods: This was a retrospective chart review of patients seen at a tertiary referral center from 1999 to 2023 with stromal keratitis who tested positive for CMV by directed polymerase chain reaction of aqueous fluid or corneal tissue. Results: This series describes 5 patients, 4 of whom presented with anterior uveitis and stromal keratitis and were confirmed to be positive for CMV through the polymerase chain reaction of aqueous fluid. The fifth patient experienced recurrent corneal graft failures, with the most recent failed graft being positive for CMV based on immunohistochemical stains of the corneal stroma. The average age of patients was 62 years (range 36–80 years). Only 1 patient (20%) exhibited elevated intraocular pressure with stellate keratic precipitates at the initial presentation, whereas 3 other patients (60%) had a known history of glaucoma. Conclusions: Uveitis specialists are well aware of CMV as a cause of recurrent, hypertensive anterior uveitis but should also consider CMV in cases featuring stromal keratitis. The corneal endothelium may serve as a reservoir for both anterior uveitis and development of corneal stromal inflammation as demonstrated by the immunohistopathology exhibited in 1 case.

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Section: Discussionmentioning

confidence: 99%

Stromal Keratitis Associated With Cytomegalovirus Anterior Uveitis

Pisitpayat,

Mentreddy,

Pekmezci

et al. 2024

Cornea

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Advanced bioengineering strategies broaden the therapeutic landscape for corneal failure

Al Monla,

Daien,

Michon

2024

Front. Bioeng. Biotechnol.

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The cornea acts as the eye foremost protective layer and is essential for its focusing power. Corneal blindness may arise from physical trauma or conditions like dystrophies, keratitis, keratoconus, or ulceration. While conventional treatments involve medical therapies and donor allografts—sometimes supplemented with keratoprostheses—these options are not suitable for all corneal defects. Consequently, the development of bioartificial corneal tissue has emerged as a critical research area, aiming to address the global shortage of human cornea donors. Bioengineered corneas hold considerable promise as substitutes, with the potential to replace either specific layers or the entire thickness of damaged corneas. This review first delves into the structural anatomy of the human cornea, identifying key attributes necessary for successful corneal tissue bioengineering. It then examines various corneal pathologies, current treatments, and their limitations. Finally, the review outlines the primary approaches in corneal tissue engineering, exploring cell-free, cell-based, and scaffold-based options as three emerging strategies to address corneal failure.

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Interstitial Keratitis

Cited by 2 publications

References 69 publications

Stromal Keratitis Associated With Cytomegalovirus Anterior Uveitis

Stromal Keratitis Associated With Cytomegalovirus Anterior Uveitis

Advanced bioengineering strategies broaden the therapeutic landscape for corneal failure

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