2020
DOI: 10.3390/ijms21103649
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Interstitial Leydig Cell Tumorigenesis—Leptin and Adiponectin Signaling in Relation to Aromatase Expression in the Human Testis

Abstract: Although epidemiological studies from the last years report an increase in the incidences of Leydig cell tumors (previously thought to be a rare disease), the biochemical characteristics of that tumor important for understanding its etiology, diagnosis, and therapy still remains not completely characterized. Our prior studies reported G-protein coupled estrogen receptor signaling and estrogen level disturbances in Leydig cell tumors. In addition, we found that expressions of multi-level-acting lipid balance- a… Show more

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Cited by 19 publications
(14 citation statements)
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“…Currently, testicular GPER localization has been confirmed in a few mammalian species in normal and pathological conditions as well as in testicular primary cells in vitro and cell lines [17]. Our previous research shows expression of GPER in bank vole, mouse, boar, and human testes with leydigioma and GPER interactions with various proteins and lipids [14,15,62,63,70]. Interestingly, GPER has been found in several subcellular compartments, including the internal membrane of the endoplasmic reticulum, nucleus, and even in a chromatin-binding protein under certain circumstances [71], as confirmed in this study.…”
Section: Discussionmentioning
confidence: 96%
“…Currently, testicular GPER localization has been confirmed in a few mammalian species in normal and pathological conditions as well as in testicular primary cells in vitro and cell lines [17]. Our previous research shows expression of GPER in bank vole, mouse, boar, and human testes with leydigioma and GPER interactions with various proteins and lipids [14,15,62,63,70]. Interestingly, GPER has been found in several subcellular compartments, including the internal membrane of the endoplasmic reticulum, nucleus, and even in a chromatin-binding protein under certain circumstances [71], as confirmed in this study.…”
Section: Discussionmentioning
confidence: 96%
“…Visfatin has been observed in human spermatozoa and concentrations in seminal plasma were found to be higher than blood plasma [ 28 ]. Lastly, a link between adiponectin and leptin and estrogen signalling interactions has been reported in Leydig cell tumours [ 29 ]. Since data regarding apelin, chemerin and vaspin functioning at the testicular level are limited, or even completely absent [ 4 , 30 , 31 ], understanding the relationship between these adipokines and androgens is of special interest.…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, several immune therapies have also been approved for patients with metastatic melanoma, but their response rates are lower than those achieved with the targeted therapies [ 4 ]. In recent years, the significance of metabolic reprogramming in cancer initiation, maintenance, progression and development of chemoresistance has been often underlined [ 1 , 6 ].…”
Section: Introductionmentioning
confidence: 99%