Interstitial Lung Disease and Sarcoidosis

Sharp, Michelle; Mohd, Mustafa Ali; Farah, N.; Bonham, Catherine A.

doi:10.1016/j.ccm.2023.06.003

Cited by 5 publications

(2 citation statements)

References 94 publications

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“…Interstitial lung diseases (ILDs) are defined as a heterogeneous group of idiopathic or secondary conditions that share a similar clinical, radiological, and histologic pattern characterized by inflammation and fibrosis involving the lung interstitium [1]. Overall, the prevalence of ILDs is approximately 200 individuals per 100,000 [2]. An early and accurate differential diagnosis among undetermined ILDs is usually pivotal to predicting prognosis and determining the best pharmacological therapy.…”

Section: Introductionmentioning

confidence: 99%

“…An early and accurate differential diagnosis among undetermined ILDs is usually pivotal to predicting prognosis and determining the best pharmacological therapy. International consensus guidelines recommend the need for a precise histopathological diagnosis in undetermined ILD patients in whom clinical, laboratory, and high-resolution computed tomography findings, preferably discussed within a multidisciplinary panel, prove insufficient to make a confident diagnosis [2,3]. In these instances, surgical lung biopsy is still the recommended diagnostic procedure despite the proposal of alternative techniques such as transbronchial lung cryobiopsy [4].…”

Section: Introductionmentioning

confidence: 99%

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Spontaneous Ventilation Thoracoscopic Lung Biopsy in Undetermined Interstitial Lung Disease: Systematic Review and Meta-Analysis

Patirelis,

Elia,

Cristino

et al. 2024

JCM

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Thoracoscopic surgical biopsy has shown excellent histological characterization of undetermined interstitial lung diseases, although the morbidity rates reported are not negligible. In delicate patients, interstitial lung disease and restrictive ventilatory impairment morbidity are thought to be due at least in part to tracheal intubation with single-lung mechanical ventilation; therefore, spontaneous ventilation thoracoscopic lung biopsy (SVTLB) has been proposed as a potentially less invasive surgical option. This systematic review summarizes the results of SVTLB, focusing on diagnostic yield and operative morbidity. A systematic search for original studies regarding SVTLB published between 2010 to 2023 was performed. In addition, articles comparing SVTLB to mechanical ventilation thoracoscopic lung biopsy (MVTLB) were selected for a meta-analysis. Overall, 13 studies (two before 2017 and eleven between 2018 and 2023) entailing 675 patients were included. Diagnostic yield ranged from 84.6% to 100%. There were 64 (9.5%) complications, most of which were minor. There was no 30-day operative mortality. When comparing SVTLB to MVTLB, the former group showed a significantly lower risk of complications (p < 0.001), whereas no differences were found in diagnostic accuracy. The results of this review suggest that SVTLB is being increasingly adopted worldwide and has proven to be a safe procedure with excellent diagnostic accuracy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Spontaneous Ventilation Thoracoscopic Lung Biopsy in Undetermined Interstitial Lung Disease: Systematic Review and Meta-Analysis

Patirelis,

Elia,

Cristino

et al. 2024

JCM

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Interstitial lung diseases in inborn errors of immunity

Sullivan,

Maniam,

Maglione

2023

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review Our goal is to review current understanding of interstitial lung disease (ILD) affecting patients with inborn errors of immunity (IEI). This includes understanding how IEI might predispose to and promote development or progression of ILD as well as how our growing understanding of IEI can help shape treatment of ILD in these patients. Additionally, by examining current knowledge of ILD in IEI, we hope to identify key knowledge gaps that can become focus of future investigative efforts. Recent findings Recent identification of novel IEI associated with ILD and the latest reports examining treatment of ILD in IEI are included. Of noted interest, are recent clinical studies of immunomodulatory therapy for ILD in common variable immunodeficiency. Summary ILD is a frequent complication found in many IEI. This article provides a guide to identifying manifestations of ILD in IEI. We review a broad spectrum of IEI that develop ILD, including antibody deficiency and immune dysregulation disorders that promote autoimmunity and autoinflammation. This work integrates clinical information with molecular mechanisms of disease and diagnostic assessments to provide an expedient overview of a clinically relevant and expanding topic.

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