Interstitial Lung Disease in Connective Tissue Diseases Other Than Systemic Sclerosis

Crestani, Bruno; Debray, Marie‐Pierre; Danel, Claire; Neuville, Mathilde; Borie, R.; Taillé, Camille; Plantier, Laurent; Aubier, Michel

doi:10.1007/978-1-4471-2401-6_26

Cited by 2 publications

(3 citation statements)

References 191 publications

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“…Sjögren's syndrome Airway disease and ILD are frequent manifestations of pulmonary involvement in SS [111]. Lymphocytic infiltration of the upper airway mucosa may cause hoarseness and persistent dry cough.…”

Section: Systemic Sclerosismentioning

confidence: 99%

Connective tissue diseases, multimorbidity and the ageing lung

2016

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Connective tissue diseases encompass a wide range of heterogeneous disorders characterised by immune-mediated chronic inflammation often leading to tissue damage, collagen deposition and possible loss of function of the target organ. Lung involvement is a common complication of connective tissue diseases. Depending on the underlying disease, various thoracic compartments can be involved but interstitial lung disease is a major contributor to morbidity and mortality. Interstitial lung disease, pulmonary hypertension or both are found most commonly in systemic sclerosis. In the elderly, the prevalence of connective tissue diseases continues to rise due to both longer life expectancy and more effective and better-tolerated treatments. In the geriatric population, connective tissue diseases are almost invariably accompanied by age-related comorbidities, and disease- and treatment-related complications, which contribute to the significant morbidity and mortality associated with these conditions, and complicate treatment decision-making. Connective tissue diseases in the elderly represent a growing concern for healthcare providers and an increasing burden of global health resources worldwide. A better understanding of the mechanisms involved in the regulation of the immune functions in the elderly and evidence-based guidelines specifically designed for this patient population are instrumental to improving the management of connective tissue diseases in elderly patients.

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Section: Systemic Sclerosismentioning

confidence: 99%

Connective tissue diseases, multimorbidity and the ageing lung

2016

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“…In this scenario, ILD develops in the context of a well‐established CTD with characteristic manifestations fulfilling international classification criteria of one of the CTD . This is the least complex of the three scenarios with regard to diagnosis.…”

Section: Suspecting Connective Tissue Disease In a Patient With Intermentioning

confidence: 99%

“…Interstitial lung disease (ILD) can occur in any of the CTD with varying frequency and severity . Previously lumped together as ‘CTD‐associated ILD’, the different conditions have recently been described into more detail, with some emphasis on patterns associated with each of the CTD.…”

Section: Introductionmentioning

confidence: 99%

Idiopathic interstitial pneumonias with connective tissue diseases features: A review

Cottin

2015

Respirology

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A systematic approach is recommended to search for clinical and biological features of connective tissue disease (CTD) in any patient with interstitial lung disease (ILD). In the diagnostic approach to ILD, a diagnosis of CTD should be considered particularly in women and subjects younger than 50 years, and in those with an imaging and/or pathological pattern of non-specific interstitial pneumonia. However, the diagnosis of CTD may be difficult when ILD is the presenting or the dominant manifestation of CTD. A proportion of patients with ILD present symptoms that belong to the spectrum of CTD and/or biological autoimmune features, but do not fulfil diagnostic criteria for a given CTD. Some imaging and histopathological patterns may also suggest the presence of an underlying CTD. Although studies published to date used heterogeneous definitions and terminology for this condition, evidence is accumulating that even limited CTD features are relevant regarding symptoms, imaging features, pathological pattern and possibly evolution to overt CTD, whereas the impact on prognosis needs confirmation. Conversely, autoantibodies alone do not seem to impact the prognosis or management in patients with otherwise typical idiopathic pulmonary fibrosis and no extra-pulmonary manifestation. A collective international multidisciplinary effort has proposed a uniform definition and criteria for 'interstitial pneumonia with autoimmune features', a condition characterized by limited CTD features occurring in the setting of ILD, with the aim of fostering future clinical studies. Referral of ILD patients suspect to have CTD to a rheumatologist and possibly multidisciplinary discussion may contribute to a better management.

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Interstitial Lung Disease in Connective Tissue Diseases Other Than Systemic Sclerosis

Cited by 2 publications

References 191 publications

Connective tissue diseases, multimorbidity and the ageing lung

Connective tissue diseases, multimorbidity and the ageing lung

Idiopathic interstitial pneumonias with connective tissue diseases features: A review

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