Interstitial Lung Disease in Polymyositis and Dermatomyositis: Analysis of Six Cases and Review of the Literature

Schwarz, Marvin I.; Matthay, Richard A.; Sahn, Steven A.; Stanford, Ray E.; Marmorstein, Barry L.; Scheinhorn, David J.

doi:10.1097/00005792-197601000-00005

Cited by 205 publications

(85 citation statements)

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“…The histopathological patterns described in patients with DPM-associated interstitial lung disease include bronchiolitis obliterans organising pneumonia, usual interstitial pneumonia (UIP), and diffuse alveolar damage [3][4][5][6]. However, most published series preceded the recognition of idiopathic nonspecific interstitial pneumonia (NSIP) [7], which has recently been reported in DPM [7,8], and may represent the most common histological pattern of DPM-associated interstitial pneumonia [1].…”

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Interstitial lung disease in amyopathic dermatomyositis, dermatomyositis and polymyositis

et al. 2003

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This study investigated interstitial pneumonia associated with amyopathic dermatomyositis, dermatomyositis and polymyositis, paying particular attention to muscular and/or cutaneous manifestations and their chronology relative to lung involvement. Patients included four males and 13 females, aged 51.7±10.8 yrs, who had surgical lung biopsy.Diagnoses included dermatomyositis (10 patients), polymyositis (four patients) and amyopathic dermatomyositis (three patients). Solitary respiratory manifestations preceded the onset of any skin or muscle disease in four cases (24%). Reticular and ground glass opacities were the most frequent computed tomography (CT) findings. Pathological review showed nonspecific interstitial pneumonia (eleven, 65%; cellular, two; cellular and fibrotic, five; fibrotic, four), usual interstitial pneumonia (two), organising pneumonia (two), lymphocytic interstitial pneumonia (one), and unclassifiable interstitial pneumonia (one). Nonspecific interstitial pneumonia was the most common histological pattern of interstitial pneumonia in patients with amyopathic dermatomyositis (three of three) and in patients with respiratory symptoms as the initial clinical manifestation of the connective tissue disease (three of four). Survival at 5 yrs was 50%.This study shows the clinician should remain alert to potential muscular or cutaneous manifestations whenever a pathological diagnosis of nonspecific interstitial pneumonia is made.

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Interstitial lung disease in amyopathic dermatomyositis, dermatomyositis and polymyositis

et al. 2003

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“…Although several histopathological patterns have been described in patients with idiopathic inflammatory myopathyassociated ILD, including organising pneumonia, usual interstitial pneumonia (UIP), organising diffuse alveolar damage and lymphocytic interstitial pneumonia [11,[15][16][17][18][19][20][21], nonspecific interstitial pneumonia (NSIP) is the most frequent histopathological pattern [11,20,22]. Idiopathic NSIP has been demonstrated to have a better prognosis than idiopathic pulmonary fibrosis (IPF) [23].…”

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Interstitial lung disease: are we missingformes frustesof connective tissue disease?

Cottin¹

2006

Eur Respir J

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“…One reason maybe that the incidence of ILD in PM/DM patients is lower in the other countries than in Japan (7, 10, ll). Although the response to corticosteroid and other immunosuppressive agents is variable in PM/DM-associated ILD (2), it has been suggested that the presence of active inflammation in lung biopsy, especially BOOP, is predictive of a good therapeutic response (4,20). In addition, ILD with anti-synthetase antibodies has been reported to be generally responsive to therapy (21).…”

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Rapidly Progressive Interstitial Lung Disease in a Dermatomyositis Patient with High Levels of Creatine Phosphokinase, Severe Muscle Symptoms and Positive Anti-Jo-1 Antibody.

Kashiwabara¹,

Ota²

2002

Intern. Med.

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It has been reported that there is a subgroup of dermatomyositis (DM) patients with rapidly progressive interstitial lung disease (ILD) who have mild muscle symptoms, slightly increased levels of muscle enzymes, and absence of anti-Jo-1 antibody. A 51-year-old womanwith DMwas intubated requiring mechanical ventilation because of a rapidly progressing ILD in spite of the absence of the typical poor prognostic factors. A high dose or pulse therapy of corticosteroids was not effective, but additional treatment of cyclosporine gradually improved her respiratory condition. It is not clear whya rapidly progressive ILD occurred in this case lacking poor prognostic factors. However, if corticosteroid treatment is not effective, additional administration of cyclosporine in the early period of rapidly progressive ILD may rescue deteriorating cases. (Intrenal Medicine 41: 584-588, 2002)

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Interstitial Lung Disease in Polymyositis and Dermatomyositis: Analysis of Six Cases and Review of the Literature

Cited by 205 publications

References 0 publications

Interstitial lung disease in amyopathic dermatomyositis, dermatomyositis and polymyositis

Interstitial lung disease in amyopathic dermatomyositis, dermatomyositis and polymyositis

Interstitial lung disease: are we missingformes frustesof connective tissue disease?

Rapidly Progressive Interstitial Lung Disease in a Dermatomyositis Patient with High Levels of Creatine Phosphokinase, Severe Muscle Symptoms and Positive Anti-Jo-1 Antibody.

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