Interstitial lung disease is not rare in immune-mediated necrotizing myopathy with anti-signal recognition particle antibodies

Ge, Yongpeng; Yang, Hanbo; Xiao, Xinyue; Liang, Lin; Lu, Xin; Wang, Guochun

doi:10.1186/s12890-021-01802-1

Cited by 18 publications

(11 citation statements)

References 17 publications

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“…However, the meaning of anti-SRP positivity in this patient is unclear, as pulmonary manifestations in PM/DM with anti-SRP antibody are relatively rare. Contrary to previous findings, however, a recent report showed that 45% of patients with anti-SRP-positive myositis had ILD on HRCT (15). Watchful follow-up for muscle involvement is necessary in our patient.…”

Section: ．Discussioncontrasting

confidence: 99%

COVID-19 Pneumonia Followed by Anti-signal Recognition Particle Antibody-positive Fibrosing Interstitial Lung Disease

et al. 2023

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Coronavirus disease 2019 (COVID-19) pneumonia is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is frequently accompanied by various sequelae. Interstitial lung diseases (ILDs) are observed in COVID-19 pneumonia patients after recovery, probably due to persistent inflammation in the lungs. We herein report a case of ILD with anti-signal recognition particle antibodies following severe COVID-19 pneumonia. The patient was diagnosed with ILD three months after COVID-19 pneumonia. Although the exact mechanism is unknown, the autoantibody-induced immune response might have been the pulmonary fibrosis trigger in this patient.

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Section: ．Discussioncontrasting

confidence: 99%

COVID-19 Pneumonia Followed by Anti-signal Recognition Particle Antibody-positive Fibrosing Interstitial Lung Disease

et al. 2023

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“…ILD is a kind of organ involvement in IMNM patients and affects the prognosis of the patients (35). In this study, Roseburia, which declined signi cantly in the gut microbiota of IMNM patients, was negatively correlated with the occurrence of ILD.…”

Section: Discussionmentioning

confidence: 52%

Gut Microbiota Dysbiosis Characterized by Abnormal Elevation of Lactobacillus in Patients with Immune- mediated Necrotizing Myopathy

Liang

Cheng

et al. 2023

Preprint

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Aim: The gutmicrobiotaplays an important role in human health. In this study, we aimedto investigate whether and whereby the gut microbiota communities are alteredin patients with immuno-mediated necrotizing myopathy (IMNM) and to provide new ideas for further exploring the pathogenesis of IMNM or screening its clinical therapeutic targets in the future. Methods: The gut microbiota in 42 fecal samples collected from 19 IMNM patients and 23 healthy controls (HCs) were examined by using 16S rRNA gene sequencing. Alpha and beta diversity analyseswere applied to examine the bacterial diversity and community structure between the IMNM and HC groups. Welch’s t test was performed to identify the significantly abundant taxa (phylum and genera) of bacteria between the two groups. Linear discriminant analysis (LDA) effect size (LefSe) analysis was applied to detect the most discriminatory taxa between the two groups. Spearman correlation analysis was performed to analyze the correlation between the gut microbiota and clinical indicators and the correlation network between the genera. A receiver operator characteristic (ROC) curve was used to reflect the sensitivity and specificity of microbial biomarker prediction of IMNM disease. P <0.05 was considered to be statistically significant. Results: The diversity of the gut microbiota of IMNM patients differed from that of healthy people and decreased obviously based on principal coordinate analysis (PCoA)and Chao1, Shannon and Simpson indexes (p<0.05). Analysis of the composition and abundance distribution of gut microbiota showed thatin IMNM patients, the relative abundances of Bacteroides, Roseburiaand Coprococcus were decreased compared to thosein the HC group, while the relative abundancesof Lactobacillus and Streptococcus were relatively increased. Furthermore, in IMNM patients, the relative abundance of Lactobacillus was positively correlated with the levels of anti-signal recognition particle (SRP) antibodies and anti-Ro52 antibodies and erythrocyte sedimentation rate (ESR), while Streptococcus was positively correlated with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies and C-reactive protein (CRP). Roseburia was negatively correlated with myoglobin (MYO), cardiac troponin T (cTnT), ESR, CRP and the occurrence of interstitial lung disease (ILD). Bacteroides was negatively correlated with ESR and CRP, and Coprococcus was negatively correlated with ESR. Finally, we constructed a prediction model using thetop five differential genera to distinguish IMNM patients from healthy individuals, which was verified using an ROC curve (area under curve: 87%, 95% confidence interval: 73–100%). Conclusion: We observed a characteristic compositional change in the gut microbiota with an abnormal elevation of Lactobacillus in IMNM patients, which was accompanied by changes in clinical indicators. This suggests that gut microbiota dysbiosis occurs in IMNM patients and iscorrelated with systemic autoimmune features.

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“…A work that reviewed the medical records of IMNM patients positive for anti-SRP antibodies showed that 45% of patients were diagnosed with ILD based on lung imaging, mostly nonspecific interstitial pneumonia (NSIP) but also organising pneumonia in a third of patients (76). A third of patients with available PFTs had mild ILD, defined as a percentage of predicted FVC (%pFVC) over 75% and a percentage of predicted diffusing capacity of the lung for carbon monoxide (DLCO%) over 55%, and more than half had moderate ILD (%pFVC 50 to 75% or %pDLCO 35 to 55%) (76). The average age at the time of ILD onset was significantly higher than that of patients without ILD (76).…”

Section: Take-home Messagesmentioning

confidence: 99%

“…A third of patients with available PFTs had mild ILD, defined as a percentage of predicted FVC (%pFVC) over 75% and a percentage of predicted diffusing capacity of the lung for carbon monoxide (DLCO%) over 55%, and more than half had moderate ILD (%pFVC 50 to 75% or %pDLCO 35 to 55%) (76). The average age at the time of ILD onset was significantly higher than that of patients without ILD (76). Notably, the frequency of dysphagia in the ILD group was higher than in the group without ILD (76).…”

Section: Take-home Messagesmentioning

confidence: 99%

“…The average age at the time of ILD onset was significantly higher than that of patients without ILD (76). Notably, the frequency of dysphagia in the ILD group was higher than in the group without ILD (76). Since MSA became clinically available and different IIM subsets were better characterised, it is often easier to distinguish IMNM from other IIM subtypes than from IIM mimickers, such as limbgirdle muscular dystrophy (LGMD) 2B and lipid storage myopathy (LSM).…”

Section: Take-home Messagesmentioning

confidence: 99%

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Idiopathic inflammatory myopathies: one year in review 2022

Cardelli

Zanframundo

Cometi

et al. 2023

Clinical and Experimental Rheumatology

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Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of disorders in which chronic inflammation of the skeletal muscle, leading to muscle weakness, is a common feature. Different phenotypes have been identified within the IIM spectrum based on extra-muscular manifestations, immunology, muscle histology, responsiveness to therapy, and prognosis. The pathogenesis, classification, treatment, and prognosis of the different IIM subtypes are subject to active discussion and research. This review highlights the most relevant literature published on this topic over the last year.

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Interstitial lung disease is not rare in immune-mediated necrotizing myopathy with anti-signal recognition particle antibodies

Cited by 18 publications

References 17 publications

COVID-19 Pneumonia Followed by Anti-signal Recognition Particle Antibody-positive Fibrosing Interstitial Lung Disease

COVID-19 Pneumonia Followed by Anti-signal Recognition Particle Antibody-positive Fibrosing Interstitial Lung Disease

Gut Microbiota Dysbiosis Characterized by Abnormal Elevation of Lactobacillus in Patients with Immune- mediated Necrotizing Myopathy

Idiopathic inflammatory myopathies: one year in review 2022

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