Interstitial microwave treatment for cancer: historical basis and current techniques in antenna design and performance

Ryan, Thomas P.; Brace, Christopher L.

doi:10.1080/02656736.2016.1214884

Cited by 45 publications

(38 citation statements)

References 131 publications

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“…This section reports coefficients of two dimensional fits of dielectric properties for mean, upper, lower, and standard deviation envelopes for the composite dataset (i.e., combining data for both porcine and bovine tissue). Table I provides coefficients for parametrization of relative allpermittivity, which ows to treat this parameter as a function of temperature and frequency [according to (1) and (2)] in the reported temperature intervals. Table II provides fitting coefficients for parametrization of the effective conductivity as a function of temperature and frequency [according to (1) and (2)] in reported temperature intervals.…”

Section: Fitting Coefficients For Overall Datamentioning

confidence: 99%

“…Computational models are widely used to guide the design and optimization of MWA applicators, to comparatively assess the impact of energy‐delivery strategies on ablation outcome, and for characterizing applicator performance in a variety of tissue types . Computational models are also being developed for use as treatment planning tools that may assist a physician in selecting treatment parameters that maximize the likelihood of achieving a favorable treatment outcome .…”

Section: Introductionmentioning

confidence: 99%

“…Microwave ablation (MWA) systems are in clinical use for image-guided thermal ablation of tumors in the liver, lung, kidney, and other sites. 1 During these procedures, microwave power radiated from the minimally invasive ablation applicator is absorbed by surrounding tissue, leading to heating. The objective of ablation procedures is to heat the targeted tissue, consisting of the tumor and a margin of surrounding tissue, to cytotoxic temperatures.…”

Section: Introductionmentioning

confidence: 99%

“…2,3 Computational models are widely used to guide the design and optimization of MWA applicators, to comparatively assess the impact of energy-delivery strategies on ablation outcome, and for characterizing applicator performance in a variety of tissue types. 1,[4][5][6][7][8] Computational models are also being developed for use as treatment planning tools that may assist a physician in selecting treatment parameters that maximize the likelihood of achieving a favorable treatment outcome. 9 For all these applications, MWA models are implemented to predict the spatial distribution of electric fields radiated by the MWA applicator into surrounding tissue, the corresponding microwave power absorption and transient temperature profiles.…”

Section: Introductionmentioning

confidence: 99%

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Broadband lung dielectric properties over the ablative temperature range: Experimental measurements and parametric models

2019

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Purpose Computational models of microwave tissue ablation are widely used to guide the development of ablation devices, and are increasingly being used for the development of treatment planning and monitoring platforms. Knowledge of temperature‐dependent dielectric properties of lung tissue is essential for accurate modeling of microwave ablation (MWA) of the lung. Methods We employed the open‐ended coaxial probe method, coupled with a custom tissue heating apparatus, to measure dielectric properties of ex vivo porcine and bovine lung tissue at temperatures ranging between 31 and 150 ∘C, over the frequency range 500 MHz to 6 GHz. Furthermore, we employed numerical optimization techniques to provide parametric models for characterizing the broadband temperature‐dependent dielectric properties of tissue, and their variability across tissue samples, suitable for use in computational models of microwave tissue ablation. Results Rapid decreases in both relative permittivity and effective conductivity were observed in the temperature range from 94 to 108 ∘C. Over the measured frequency range, both relative permittivity and effective conductivity were suitably modeled by piecewise linear functions [root mean square error (RMSE) = 1.0952 for permittivity and 0.0650 S/m for conductivity]. Detailed characterization of the variability in lung tissue properties was provided to enable uncertainty quantification of models of MWA. Conclusions The reported dielectric properties of lung tissue, and parametric models which also capture their distribution, will aid the development of computational models of microwave lung ablation.

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Section: Fitting Coefficients For Overall Datamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Broadband lung dielectric properties over the ablative temperature range: Experimental measurements and parametric models

2019

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“…3 The use of microwaves for thermal cancer treatment was first reported in 1980s for the treatment of liver tumors. 4 Subsequently, MWA method has been employed for ablating variety of tumors in the bone, 5,6 kidney, 7,8 lung, [9][10][11] pancreas, 12 and breast, 13 as well as for non-oncologic applications, as follows, treatment of endometrial bleeding, 14 uterine myomas, 15 and atrial fibrillation. 16 The basic MWA system typically consists of the microwave power generator, an interstitial antenna applicator, and a cooling system.…”

Section: Introductionmentioning

confidence: 99%

Sensitivity analysis of critical parameters affecting the efficacy of microwave ablation using Taguchi method

Singh

Repaka

Al‐Jumaily

2018

Int J RF Microw Comput Aided Eng

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Microwave ablation (MWA) is a minimally invasive thermal treatment modality that has already evolved as a promising alternative to radiofrequency ablation for treating different types of malignant and benign tumors, especially ≥3 cm in diameter. The efficacy of thermal ablative therapies is mainly judged by the ablation volume attained post‐ablation. In this regards, the present study aims at analyzing the influence of six critical parameters, as follows, relative permittivity, electrical conductivity, volumetric heat capacity, thermal conductivity, blood perfusion rate, and applied power on the ablation volume attained during MWA. Taguchi's L27 orthogonal array has been adopted for the current problem with six input variables having three levels each. The electric and thermophysical properties considered in the study have been derived from liver, lung, breast, and kidney. Finite element method (FEM) based numerical simulations of MWA have been conducted on three‐dimensional homogeneous model of biological tissue using coaxial single slot microwave antenna. Further, the ranking and the contribution of each parameter on the ablation volume attained during MWA have been quantified using analysis of variance. The corollaries drawn from the study would be useful to the clinical practitioners during the treatment planning stage of the MWA.

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Combination of MRI‐Guided High‐Intensity Focused Ultrasound and Bioluminescent Biological Systems to Assess Thermal Therapies for Tumor and Tumor Microenvironment

Jeanjean¹,

Hamrani

Genevois³

et al. 2022

Adv Materials Technologies

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This work presents an integrated technology for assessing in vivo anti-cancer treatments in mice, based on various heating conditions. Bioluminescence imaging (BLI) was used to assess the physiological response of tumor and tumor microenvironment (TME) to heat treatment induced by magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU). Transgenic tumor cells and mouse models with either constitutive or thermoinduced luciferase expressions were combined to monitor cell viability and heat-induced processes in the tumor and TME. BLI performed after MRgHIFU heating shows that a moderate increase in temperature (45°C) over 5 min can be exploited to promote heat-activable treatments in the tumor and its TME, without inducing direct cell death. A higher temperature rise over a shorter exposure time can induce cell death in the tumor, as revealed by a reduction in the BLI signal after treatment. Under these conditions, BLI also revealed that the TME can be stimulated by heat without inducing necrosis. These integrated technologies and models are useful to assess, in vivo in mice, the efficacy of various anticancer strategies exploiting local heat deposition by noninvasive MRgHIFU, including those combining tumor ablation with local drug administration using thermosensitive nanovehicles.

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Interstitial microwave treatment for cancer: historical basis and current techniques in antenna design and performance

Cited by 45 publications

References 131 publications

Broadband lung dielectric properties over the ablative temperature range: Experimental measurements and parametric models

Broadband lung dielectric properties over the ablative temperature range: Experimental measurements and parametric models

Sensitivity analysis of critical parameters affecting the efficacy of microwave ablation using Taguchi method

Combination of MRI‐Guided High‐Intensity Focused Ultrasound and Bioluminescent Biological Systems to Assess Thermal Therapies for Tumor and Tumor Microenvironment

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