Interstitial nephritis with acute renal failure after erythromycin.

Rosenfeld, J; Gura, Victor; Boner, G; Ben-Bassat, M; Livni, E

doi:10.1136/bmj.286.6369.938

Cited by 27 publications

(12 citation statements)

References 6 publications

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“…Macrolide antibiotics can induce acute liver injury as well as acute and chronic kidney disease 28–31 . Acute kidney injury from macrolides including erythromycin, azithromycin and telithromycin is usually secondary to acute interstitial nephritis that can be reversed by the administration of steroids 28–30 .…”

Section: Discussionmentioning

confidence: 99%

Prevalence, Severity, and Impact of Renal Dysfunction in Acute Liver Failure on the US Liver Transplant Waiting List

et al. 2015

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Background & Aims Although renal dysfunction is a known complication of acute liver failure (ALF), its frequency, severity and impact among patients with ALF on the US liver transplant list are not well defined. Methods Organ Procurement and Transplantation data for ALF patients listed as status 1/1A from 2002–2012 were analyzed. The frequency and severity of renal dysfunction at the time of listing [the latter was categorized in 5 stages using estimated GFR (eGFR) according to Chronic Kidney Disease Epidemiology Collaboration creatinine 2009 equation) were determined and the association between renal dysfunction and waiting list mortality was assessed using Cox proportional hazard regression analysis. Results There were a total of 2,280 adult patients with ALF, including 56% with renal dysfunction (defined as eGFR <60 ml/min/1.73m2) at listing. The highest proportion of patients with renal dysfunction was among those with ALF caused by hemolysis, elevated liver enzymes, low platelet count (HELLP) syndrome, fatty liver disease of pregnancy, heat stroke/hyperthermia-, hepatitis A virus, drug-induced liver injury due to acetaminophen (APAP), phenytoin, trimethoprim-sulfamethoxazole and macrolides. Despite the fact that 69% (468/674) of patients with APAP-induced ALF listed as status 1/1A had renal dysfunction, only 0.9% underwent simultaneous liver-kidney transplantation. Six-week survival probabilities in patients with ALF on the liver transplant waiting list were 71%, 59%, 56%, 59% and 42% with renal dysfunction stages of 1, 2, 3, 4, and 5, respectively. Multivariate analysis showed that after controlling for age, etiology of ALF, INR, total bilirubin and region, the relative risk of death increased progressively as eGFR declined (P<0.0001). Conclusions Among patients with ALF on the liver transplant waiting list, renal dysfunction was common (overall prevalence of 56%). Most importantly, severe renal dysfunction was associated with significantly increased mortality.

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Section: Discussionmentioning

confidence: 99%

Prevalence, Severity, and Impact of Renal Dysfunction in Acute Liver Failure on the US Liver Transplant Waiting List

et al. 2015

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“…Macrolide antibiotics can induce acute liver injury as well as acute and chronic kidney disease [28][29][30][31] . Acute kidney injury from macrolides including erythromycin, azithromycin and telithromycin is usually secondary to acute interstitial nephritis that can be reversed by the administration of steroids [28][29][30] .…”

Section: Author Manuscript Author Manuscriptmentioning

confidence: 99%

“…Acute kidney injury from macrolides including erythromycin, azithromycin and telithromycin is usually secondary to acute interstitial nephritis that can be reversed by the administration of steroids [28][29][30] .…”

Section: Author Manuscript Author Manuscriptmentioning

confidence: 99%

481 Prevalence, Severity and Impact of Renal Dysfunction in Acute Liver Failure on the U.S. Liver Transplant Waiting List

Urrunaga¹,

Mindikoğlu²

2014

Gastroenterology

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“…Drug-in duced multisystem involvement is rare in pa tients; its presence in our patient (cutaneous reaction, eosinophilia and hepatic damage) and the renal cell infiltrate with many eosino phils are strong pointers to erythromycin as a probable culprit. Up to the time of this study erythromvcin-induced AIN has only been es tablished and biopsy proven unequivocally once [5],…”

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confidence: 99%