Interstitial pneumonitis during lamotrigine therapy

Saravanan, Narayanamoorti; Otaiku, Olayiwala Musibay; Namushi, Robert

doi:10.1111/j.1365-2125.2005.02493.x

Cited by 5 publications

(2 citation statements)

References 8 publications

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“…18 Saravanan et al demonstrated that increased AED drug concentrations of lamotrigine triggered a diffuse interstitial process of relatively recent onset, with features consistent with diffuse lung disease. 19 In agreement with our study is Travis et al's who reported that nonspecific interstitial pneumonia (NSIP), lymphocytic interstitial pneumonia, or even patchy alveolar septal lymphoplasmacytic infiltrates without appreciable airway disease or parenchymal scarring are the most common pulmonary morphologic patterns that are associated with anticonvulsants and other agent toxicities. 20 Furthermore, Nikaido et al and El Khayat et al concluded that many antiepileptic drugs induced interstitial pneumonia and disturbed pulmonary functions for epileptic patients on regular prolonged use and they demonstrated that drug-induced interstitial lung disease should be considered as a possible complication of anticonvulsant treatment.…”

Section: Discussionsupporting

confidence: 93%

Chronic histopathological effects of levetiracetam on some internal organs of adult albino rats

Omer

Kutb

2015

Egyptian Journal of Forensic Sciences

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Purpose: To assess effects of Levetiracetam (LEV) within its therapeutic range at a 54 mg/day and 1/4 LD50 = 70 mg/kg body weight for white albino male and female rats weighing to an average of 180 ± 60 g has been studied in order to demonstrate whether LEV would effect the internal organs at the histological level. Methods: Animals were randomly separated into control (n = 20), study group I (n = 20) and study group II (n = 20). They were obtained from the animal house, Assuit University. They were maintained in environmentally controlled rooms at a temperature of 28-32°C, 40-60% humidity, in a noise free environment. Oral administration of 54 mg/day and 70 mg/kg levetiracetam for groups I and II, respectively, was given while physiologic saline (0.045 ml) was given to the control group. Results: Microscopic evaluation of the intestine, kidney, suprarenal glands and spleen, revealed that there was no statistical difference between treated and control groups. Four specimens of the liver out of 20 (20%), showed focal necrosis around central veins. Lung sections which were obtained from 15 out of 20 (75.0%) in the study group II showed various histopathological findings compared to those of the control group. These findings include thickening of interstitial septa, interstitial fibrosis, chronic inflammatory cells infiltration, and congestion of blood vessels. Conclusions: LEV, is considered as safe drug in its therapeutic dose. Its safety needs further studies with long term follow-up. ª 2014 Production and hosting by Elsevier B.V. on behalf of Forensic Medicine Authority.

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Section: Discussionsupporting

confidence: 93%

Chronic histopathological effects of levetiracetam on some internal organs of adult albino rats

Omer

Kutb

2015

Egyptian Journal of Forensic Sciences

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“…The present case report portrays severe respiratory deterioration that occurred in an adult African male inpatient immediately after the introduction of lamotrigine and that required intensive internal treatment. The consequently presumed diagnosis of a lamotrigine-induced interstitial pneumonitis is supported by previous singular observations on anticonvulsant hypersensitivity syndrome (ACHS), lamotrigine-associated pneumonitis, and the so-called drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome with lung involvement ( 11 – 15 ). Previous reports portray both subacute and acute progressions of lamotrigine-induced pulmonary changes.…”

Section: Discussionmentioning

confidence: 73%

Case report: Interstitial pneumonitis after initiation of lamotrigine

et al. 2023

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The second-generation anticonvulsant lamotrigine is widely used in the psychiatric field as a mood stabilizer or antidepressant augmentation therapy. Although particularly older anticonvulsants are known for their potential to cause hypersensitivity syndromes, newer antiepileptic drugs do hold a certain risk as well. Presenting a case of a 32-year-old male inpatient of African ethnicity suffering from a primary severe depressive episode in the course of a recurrent major depressive disorder, we report the occurrence of a rapid-onset drug-induced pneumonitis. Herewith, the interstitial pneumonitis occurred after the initiation of 25 mg lamotrigine as an augmentation therapy. Except for the clear temporal correlation between the administration of lamotrigine and the onset of pneumonitis, we did not reveal any further potentially causal diagnostic hints. Importantly, no relevant genetic variations of metabolizing enzymes or drug interactions resulting in lamotrigine overdosage as a potential cause of toxicity were identified. Our experience with a potentially life-threatening adverse drug reaction shortly after the initiation of the largely well-tolerated lamotrigine suggests a potential side effect under the second-generation anticonvulsant although similar adverse events are deemed to be very rare.

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Current awareness: Pharmacoepidemiology and drug safety

2006

Pharmacoepidemiology and Drug

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 20 sections: 1 Books, Reviews & Symposia; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Teratogens/fetal exposure; 20 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Interstitial pneumonitis during lamotrigine therapy

Cited by 5 publications

References 8 publications

Chronic histopathological effects of levetiracetam on some internal organs of adult albino rats

Chronic histopathological effects of levetiracetam on some internal organs of adult albino rats

Case report: Interstitial pneumonitis after initiation of lamotrigine

Current awareness: Pharmacoepidemiology and drug safety

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