Interstitial pulmonary fibrosis after severe exposure to welding fumes

Buerke, Ute; Schneider, Joachim; Rösler, J.; Woitowitz, H.‐J.

doi:10.1002/ajim.10055

Cited by 56 publications

(32 citation statements)

References 33 publications

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“…Our findings are in line with these studies. Exposure to iron fumes or dust may give rise to siderosis, an accumulation of iron in the lungs (14,22,23), interstitial pulmonary fibrosis, or siderofibrosis (24), which have been suspected to be associated with an increased risk of lung cancer (25,26). IARC has defined welding fumes as possibly carcinogenic to humans (27).…”

Section: Discussionmentioning

confidence: 99%

Exposure to iron and welding fumes and the risk of lung cancer

Siew¹,

Kauppinen²,

Kyyrönen³

et al. 2008

Scand J Work Environ Health

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Section: Discussionmentioning

confidence: 99%

Exposure to iron and welding fumes and the risk of lung cancer

Siew¹,

Kauppinen²,

Kyyrönen³

et al. 2008

Scand J Work Environ Health

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“…For each worker, the list of tasks and materials resulting in potential exposures to asbestos and silica was reviewed, as these were the primary exposures likely related to the risk of pneumoconiosis among these workers. Welding/cutting fume exposures also were reviewed as some studies have shown intense welding exposures to be associated with an increased risk of interstitial pulmonary fibrosis [Buerke et al, 2002]. In many instances, a worker reported multiple tasks or materials, which would generate an exposure.…”

Section: Descriptive and Stratified Analysesmentioning

confidence: 99%

Surveillance of respiratory diseases among construction and trade workers at Department of Energy nuclear sites

Dement

Welch

Bingham

et al. 2003

American J Industrial Med

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Continued surveillance of workers is important given their increased risk of disease progression and their risk for asbestos related malignancies. Smoking cessation programs should also be high priority and continued abstinence for former smokers reinforced. Although the observed respiratory disease patterns are largely reflective of past exposures, these findings suggest that DOE needs to continue to review industrial hygiene control programs for work tasks involving maintenance, repair, renovation, and demolition.

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“…Therefore, the observed acceleration in mortality resulting from PM 1648 or PM 2.5 exposure was not due to renal failure. However, pulmonary toxicity and fibrosis have been reported with urban particles with the greatest toxicity seen with PM 2.5 (Churg and Brauer, 2000;Schwartz and Neas, 2000;van Zijverden et al, 2001;Buerke et al, 2002). Also, there has been a consistent link between increased incidence of mortality and morbidity due to cardiopulmonary complications and elevated levels of particulate matter in the air (Salvi et al, 1999;Kleinman et al, 2000;Huang, Hsu, and Chan, 2003;Pozzi et al, 2003).…”

Section: Discussionmentioning

confidence: 98%

Particulate Matter Immunomodulatory Effects on Autoantibody Development in New Zealand Mixed Mice

Hassani

Brown

Morandi

et al. 2004

Journal of Immunotoxicology

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Particulate matter exposures have been linked to increased mortality and morbidity that may be associated with immune dysfunction. Therefore, Lupus-prone New Zealand mixed mice (NZM) were intranasally instilled with either 30 µl saline or 30 µl saline suspensions of 500 µg acid-washed PM 1648, PM 1648 or PM 2.5 collected in Houston, TX, once a week for 4 weeks. Lung injury, mortality, and various immune dysfuntions were assessed. Accelerated mortality was observed in the PM 1648 and PM 2.5 instilled mice compared to the acid-washed PM 1648 and saline-instilled mice. PM 1648 and PM 2.5 significantly suppressed the natural development of anti-nuclear antibodies in NZM mice at 16 weeks. IgG serum levels were significantly increased in the acid-washed PM 1648 instilled mice at 8 weeks following PM instillation compared to the saline-instilled group. In contrast, IgG serum levels were significantly decreased in the PM 1648 and PM 2.5 instilled mice at 8 weeks post-PM instillation as compared to the acid-washed PM 1648 instilled group. There were increases in the amount of immune cell infiltration, fibrosis and collagen deposition within the lungs of PM 1648 and PM 2.5 groups in comparison within the saline-and acid-washed PM 1648 instilled mice. These results demonstrate that PM has an immunosuppressive effect on the development of anti-nuclear autoantibodies and modulates the IgG responses in this model of autoimmune disease.

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Interstitial pulmonary fibrosis after severe exposure to welding fumes

Abstract: While epidemiological data are limited, it is reasonable to conclude that a causal relationship exists between IPF in welders with long term exposure to high concentrations of welding fumes.

Cited by 56 publications

References 33 publications

Exposure to iron and welding fumes and the risk of lung cancer

Exposure to iron and welding fumes and the risk of lung cancer

Surveillance of respiratory diseases among construction and trade workers at Department of Energy nuclear sites

Particulate Matter Immunomodulatory Effects on Autoantibody Development in New Zealand Mixed Mice

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