Interstitial Radiotherapy with Iridium 192 in the Treatment of Early Breast Cancer

Immunohistochemical Demonstration of Estrogen Receptors on Routine Paraffin Sections of Breast Carcinomas: A Comparison with Frozen Sections and an Enzyme Immunoassay

“…Regarding the degree of histologic tumor differentia tion which obviously could be better evaluated in paraffin sections, it was found to be related to the ER presence, as has also been mentioned by other authors [6,[28][29][30]. 45], The ER content of the tumor was related to each single factor of the histologic grade, resulting thus in a positive relationship with the extent of tubule formation [29.30.45] and a negative one with the degree of nuclear atypia [28] or the mitotic figures [6.29], ER content was also related to the tumor's histologic type.…”

“…45], The ER content of the tumor was related to each single factor of the histologic grade, resulting thus in a positive relationship with the extent of tubule formation [29.30.45] and a negative one with the degree of nuclear atypia [28] or the mitotic figures [6.29], ER content was also related to the tumor's histologic type. There was a higher proportion of ER positivity in invasive lobular and mixed than in invasive ductal car cinomas [29,30], The in situ cribriform regions in invasive ductal carcinomas were usually ER-rich, while the in situ comedo regions were usually ER-negative as has been re cently mentioned by Helin et al [45] and Giri el al. [44], Finally in accordance with the results of others we found that mucinous, tubular and papillary carcinomas were ER-rich [29.…”

“…[44], Finally in accordance with the results of others we found that mucinous, tubular and papillary carcinomas were ER-rich [29. 45], while medullary ones were always ERnegative [29], Probably the intense lymphocytic infiltra tion. which is reversely related to the ER content, is res ponsible for the absence of ER in medullary carcinomas [46].…”