Interstrain differences in adolescent fear conditioning after acute alcohol exposure

Seemiller, Laurel R.; Goldberg, Lisa R.; Garcia-Trevizo, Prescilla; Gould, Thomas J.

doi:10.1016/j.brainresbull.2023.01.006

Cited by 5 publications

(1 citation statement)

References 74 publications

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“…While some evidence suggests that some long-term cognitive effects of adolescent alcohol consumption vary by sex ( Matthews et al, 2022 , 2023 ), it is important to consider that this also likely varies by genetic background. Studies examining short-term cognitive effects of acute alcohol exposure during adolescence have shown interactions between sex and genetic background to produce unique alcohol-associated learning deficits ( Seemiller et al, 2022 , 2023 ; Seemiller and Gould, 2021 ). Importantly, while the literature directly assessing adolescent alcohol exposure and cognitive decline is sparse, much of it points toward a key relationship warranting further investigation.…”

Section: Adolescentsmentioning

confidence: 99%

Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer's Disease and cognitive decline

Seemiller,

Flores-Cuadra,

Griffith

et al. 2024

Neurobiology of Stress

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Section: Adolescentsmentioning

confidence: 99%

Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer's Disease and cognitive decline

Seemiller,

Flores-Cuadra,

Griffith

et al. 2024

Neurobiology of Stress

Self Cite

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Adolescent intermittent alcohol exposure produces strain-specific cross-sensitization to nicotine and other behavioral adaptations in adulthood in C57BL/6J and DBA/2J mice

Seemiller,

Garcia-Trevizo,

Novoa

et al. 2023

Pharmacology Biochemistry and Behavior

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Alcohol and fear conditioning produce strain‐specific changes in the dorsal hippocampal transcriptome of adolescent C57BL/6J and DBA/2J mice

Seemiller,

Goldberg,

Sebastian

et al. 2024

Alcohol, Clinical and Experimental Research

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BackgroundAdolescent sensitivity to alcohol is influenced by genetic background. Data from our laboratory suggested that adolescent C57BL/6J and DBA/2J inbred mice differed in susceptibility to alcohol‐induced deficits in dorsal hippocampus‐dependent contextual fear learning.MethodsTo investigate the biological underpinnings of this strain difference, we examined dorsal hippocampus gene expression using RNA‐sequencing after alcohol or saline administration followed by Pavlovian fear conditioning across male and female C57BL/6J and DBA/2J adolescents.ResultsStrains exhibited dramatic differences in dorsal hippocampus gene expression. Specifically, C57BL/6J and DBA/2J strains differed by 3526 transcripts in males and 2675 transcripts in females. We identified pathways likely to be involved in mediating alcohol's effects on learning, including networks associated with Chrna7, a gene encoding the nicotinic cholinergic receptor alpha 7 subunit, and Fmr1, a gene encoding the fragile X messenger ribonucleoprotein.ConclusionsThese findings provide insight into the mechanisms underlying strain differences in alcohol's effects on learning and suggest that different biological networks are recruited for learning based on genetics, sex, and alcohol exposure.

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Interstrain differences in adolescent fear conditioning after acute alcohol exposure

Cited by 5 publications

References 74 publications

Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer's Disease and cognitive decline

Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer's Disease and cognitive decline

Adolescent intermittent alcohol exposure produces strain-specific cross-sensitization to nicotine and other behavioral adaptations in adulthood in C57BL/6J and DBA/2J mice

Alcohol and fear conditioning produce strain‐specific changes in the dorsal hippocampal transcriptome of adolescent C57BL/6J and DBA/2J mice

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