Interstudy repeatability of left and right ventricular volume estimations by serial‐gated tomographic radionuclide angiographies using a cadmium‐zinc‐telluride detector gamma camera

Jensen, Maria Maj; Haase, Christine; Zerahn, Bo

doi:10.1111/cpf.12178

Cited by 20 publications

(11 citation statements)

References 22 publications

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“…In terms of repeatability, the intraclass correlation coe cient of RVPFR(P) was good (ICC = 0.698), while the intraclass correlation coe cient of other groups of data was excellent (0.823 ~ 0.989) which was similar to previous studies [13,15,17,23]. It could be drawn from the Bland-Altman diagram that the repeatability con dence intervals of LVEF and RVEF of CZT-SPECT were narrower than those of C-SPECT, indicating that CZT-SPECT had better repeatability.…”

Section: Discussionsupporting

confidence: 88%

Evaluation of Biventricular Function by Cadmium-zinc-telluride SPECT Gated Tomographic Radionuclide Angiography: Comparison to Conventional SPECT

Chen

Pang

Wang

et al. 2021

Preprint

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To compare and analyze the consistency and repeatability of left ventricular (LV) and right ventricular (RV) functions obtained by radionuclide multi-gated acquisition (MUGA) with cadmium-zinc-telluride SPECT (CZT-SPECT) and conventional SPECT(C-SPECT) with sodium iodide (NaI) crystal detectors. Seventy-seven patients who underwent C-SPECT planar MUGA and CZT-SPECT tomographic MUGA on the same day were respectively enrolled and reviewed. Comparing the correlation and difference of LVEF, RVEF, PER, and PFR between the two cameras, The repeatability of the left and right ventricular function parameters obtained by the two cameras was also compared. There was a good correlation (R = 0.831, P < 0.001) of LVEF obtained by the two cameras, the comparison of RVEF (r=0.619, P＜0.001), LVPER (r=0.672, P＜0.001) and LVPFR (r=0.700, P＜0.001) showed a modest correlation and the comparison of RVPER (r=0.463, P＜0.001), LVPFR (r=0.253, P＜0.05) showed a poor correlation. In terms of repeatability, the intraclass correlation coefficient (ICC) of RVPFR(P) was good (0.698, P＜0.001), while the ICC in other groups was excellent (0.823 ~ 0.989, P ＜0.001). The repeatability of LVEF and RVEF measured by CZT-SPECT was better than C-SPECT. The repeatability of LVEF and PER measured by two cameras was better than their respective RVER and PFR. The repeatability of PER and PFR of LV was better than RV for both cameras. CZT-SPECT tomographic MUGA had a good correlation with C-SPECT cardiac planar MUGA in evaluating left and right ventricular systolic function and left ventricular diastolic function, and the repeatability above was even better. The determination of right ventricular diastolic function still needed further study. MUGA with CZT-SPECT will play an important and unique role in the clinical application of accurate evaluation of biventricular function in the future.

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Section: Discussionsupporting

confidence: 88%

Evaluation of Biventricular Function by Cadmium-zinc-telluride SPECT Gated Tomographic Radionuclide Angiography: Comparison to Conventional SPECT

Chen

Pang

Wang

et al. 2021

Preprint

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“…In the only published study, interscan reproducibility was good for LVEF's and volumes for high-efficiency SPECT acquisition. 10 The variability was higher for measures of right ventricular size and function.…”

Section: Discussionmentioning

confidence: 96%

“…The first addressed the ability to convert SPECT images to planar views, 8 the second compared the reproducibility of the assessment of LVEF by SPECT and planar techniques, 9 and the third evaluated the reproducibility of ventricular volume calculation by SPECT acquisition. 10 The ability of high-efficiency SPECT camera technology to reduce radiation exposure to patients during gated blood pool imaging has not been previously investigated. With this in mind, we assessed the diagnostic accuracy of high-efficiency SPECT gated blood pool scans compared to traditional planar scans and sought to determine the degree of radioisotope dose reduction that would be possible.…”

Section: Introductionmentioning

confidence: 99%

Radiation reduction and faster acquisition times with SPECT gated blood pool scans using a high-efficiency cardiac SPECT camera

Duvall

Guma-Demers

George

et al. 2016

Journal of Nuclear Cardiology

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High-efficiency SPECT technology can reduce radiation exposure to patients during gated blood pool imaging or decrease acquisition time while maintaining diagnostic accuracy. Based on the improved count sensitivity with high-efficiency SPECT, a 50% reduction in injected activity may be achievable while maintaining short imaging times of 5 minutes, with further reduction possible at longer imaging times.

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“…The introduction of cadmium-zinc-telluride (CZT) SPECT detector technology enabled accelerated, lowdose cardiac radionuclide imaging. [16][17][18] In addition to detecting perfusion defects, CZT-SPECT detectors allow for more precise and sophisticated evaluation of LV systolic and diastolic function, with studies showing high interstudy reproducibility of CZT-based volumetric assessment 18 and good correlation of LVEF and regional wall motion when comparing CZT-SPECT to CMR. 19 In addition, LV filling indices derived from CZT-SPECT, namely, peak filling rate (PFR) and time to PFR were shown to correlate well with echo-derived diastolic markers.…”

Section: Diastolic Assessment With Czt-spect Technologymentioning

confidence: 99%

Diastolic assessment by CZT-SPECT: Could it be the next best thing for the detection of subclinical chemotherapy-induced cardiotoxicity?

Andrikopoulou

2020

Journal of Nuclear Cardiology

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See related article, pp. 1193-1201 Advancements in modern medicine have resulted in a continuously growing population of survivors of adult and pediatric malignancies. 1 This is paralleled by an increased recognition of the cardiac damage induced by chemotherapy and radiation therapy, collectively termed ''cancer therapeutics-related cardiac dysfunction'' (CTRCD). 2 It is now well established that, left untreated, CTRCD may result in numerous adverse cardiovascular effects, namely, left ventricular (LV) dysfunction, congestive heart failure, and ultimately increased cardiovascular mortality. 3 Myocardial recovery and improved survival rely on early diagnosis of CTRCD and prompt initiation of medical therapy. 3 Noninvasive cardiac imaging has been traditionally used to detect CTRCD, namely, 2-D echocardiography (Echo), cardiac magnetic resonance (CMR), and radionuclide imaging (multi-gated acquisition, MUGA, and singlephoton emission computed tomography, SPECT). 2,4,5 These modalities are mostly geared towards quantifying the left ventricular ejection fraction (LVEF), as an index of the status of LV systolic function. 4 It is becoming increasingly evident though, that reduction in the LVEF may signify advanced and possibly irreversible cardiac damage. This emphasizes the need for detection of markers of subclinical cardiotoxicity.

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Interstudy repeatability of left and right ventricular volume estimations by serial‐gated tomographic radionuclide angiographies using a cadmium‐zinc‐telluride detector gamma camera

Abstract: The CZT detector camera has excellent reproducibility with regard to interstudy variation when assessing LV volumes and EF. Interstudy variation is considerably higher for RV volumes and EF, indicating a lack of consistency in tracing the boarders of the right ventricle.

Cited by 20 publications

References 22 publications

Evaluation of Biventricular Function by Cadmium-zinc-telluride SPECT Gated Tomographic Radionuclide Angiography: Comparison to Conventional SPECT

Evaluation of Biventricular Function by Cadmium-zinc-telluride SPECT Gated Tomographic Radionuclide Angiography: Comparison to Conventional SPECT

Radiation reduction and faster acquisition times with SPECT gated blood pool scans using a high-efficiency cardiac SPECT camera

Diastolic assessment by CZT-SPECT: Could it be the next best thing for the detection of subclinical chemotherapy-induced cardiotoxicity?

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