We derive a general and simple expression for the time-dependence of the position operator of a multi-band Hamiltonian with arbitrary matrix elements depending only on the momentum of the quasi-particle. Our result shows that in such systems the Zitterbewegung like term related to a trembling motion of the quasi-particle, always appears in the position operator. Moreover, the Zitterbewegung is, in general, a multi-frequency oscillatory motion of the quasi-particle. We derive a few different expressions for the amplitude of the oscillatory motion including that related to the Berry connection matrix. We present several examples to demonstrate how general and versatile our result is.PACS numbers: 71.70.Ej,73.22.Pr,03.65.Vf Schrödinger in his original paper has predicted a 'trembling' or in other words a rapid oscillatory motion of the center of the free wave packet for relativistic electron [1]. However, the Zitterbewegung is not strictly a relativistic effect [2-6] but can be observed in spintronic systems as well [7]. This work has initiated many other works with an aim to demonstrate the appearance of the Zitterbewegung not only for relativistic Dirac electrons. In these works a common feature is that the oscillatory motion of the free particles can be described only by one frequency.In our previous work we showed that for a wide class of Hamiltonians related to for example spintronic systems and graphene, the Zitterbewegung can be treated in a unified way [33]. Here the basic idea was that the Hamiltonian of several systems can be mapped to that modelling the precession of a virtual spin in an effective magnetic field. The coupled equations for this virtual spin precession and the orbital motion of the quasi-particle can easily be solved. Thus, the Zitterbewegung is arising because the virtual spin and the orbital motion for the quasi-particle are coupled. Our work suggests as natural question whether the phenomenon of the Zitterbewegung also arises for an even more general Hamiltonian.In the present work we extend the Zitterbewegung phenomena to a broader class of quantum Hamiltonians for free (quasi-) particles. In particularly, we derive a general and simple expression for the time-dependence of the position operator x(t) for a multi-band Hamiltonian given bywhere each matrix element is a differentiable function of the momentum p of the particle itself and n ≥ 2 is the number of degrees of freedom of the system. From our general expression for the position operator x(t) we shall show that i) the Zitterbewegung always appears for systems given by the Hamiltonian (1), i) for n > 2 the Zitterbewegung is in fact a multi-component oscillatory motion of the free quasi-particle, ii) for n = 2 we recover the results obtained earlier in the above mentioned references. To find the time dependence of the position operator x(t) of the quasi-particle in Heisenberg picture one needs to calculatewhere x(0) is the position operator at t = 0, ie, it equals to the position operator in Schrödinger picture. Because the mom...