Intersubject representational similarity analysis uncovers the impact of state anxiety on brain activation patterns in the human extrastriate cortex

Hsiao, Po-Yuan A.; Kim, M. Justin; Chou, Feng-Chun B.; Chen, Pin-Hao A.

doi:10.1007/s11682-024-00854-1

Brain Imaging and Behavior

2024

DOI: 10.1007/s11682-024-00854-1

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Intersubject representational similarity analysis uncovers the impact of state anxiety on brain activation patterns in the human extrastriate cortex

Po-Yuan A. Hsiao,

M. Justin Kim,

Feng-Chun B. Chou

et al.

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2024

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Cited by 1 publication

References 49 publications

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Similarity in Early Life Stress Exposure is Associated with Similarity in Neural Representations in Early Adulthood

Ilomäki,

Lindblom,

Flykt

et al. 2024

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Early life stress (ELS) has profound implications for developmental trajectories, yet the neural mechanisms underlying its long-term effects remain incompletely understood. In the present study, we examined whether interindividual similarity in ELS exposure aligns with similarity in neural representations and behavioral task performance in early adulthood. Leveraging a 20-year longitudinal dataset of Finnish families, we evaluated 87 young adults who underwent functional magnetic resonance imaging (fMRI) during an emotional go/no-go task. Intersubject representational similarity analysis (IS-RSA) was used to assess the associations between pairwise similarities in prospectively or retrospectively measured ELS, neural representations in 360 cortical regions, and task performance. We incorporated multidimensional scaling and Procrustes alignment to visualize interindividual differences in representational spaces. Prospective ELS, but not Retrospective ELS, was significantly associated with neural representational similarity across 40 cortical regions, including the anterior insula, frontal operculum, and anterior cingulate cortex. Higher Prospective ELS was also linked to reduced detection sensitivity, mediated by neural responses to angry facial expressions. These findings highlight the systematic and chronic effects of more moderate ELS on brain development and emphasize the value of prospective measurements and advanced similarity analyses in capturing the nuanced influences of ELS. By integrating spatial and shape analytical techniques, the present study provides new insights into the long-term neurobiological correlates of ELS and introduces novel methodological tools for neurodevelopmental research.

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Similarity in Early Life Stress Exposure is Associated with Similarity in Neural Representations in Early Adulthood

Ilomäki,

Lindblom,

Flykt

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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Intersubject representational similarity analysis uncovers the impact of state anxiety on brain activation patterns in the human extrastriate cortex

Cited by 1 publication

References 49 publications

Similarity in Early Life Stress Exposure is Associated with Similarity in Neural Representations in Early Adulthood

Similarity in Early Life Stress Exposure is Associated with Similarity in Neural Representations in Early Adulthood

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