1965
DOI: 10.1152/jappl.1965.20.4.621
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Intertissue diffusion effect for inert fat-soluble gases

Abstract: An approximately constant 5% difference in alveolar concentration of nitrous oxide and cyclopropane exists when these two gases are administered simultaneously to human subjects. This difference in uptake cannot be fully explained within the traditional framework of a perfusion-limited, multi-compartment model of inert gas exchange. It is proposed that this difference reflects direct diffusion from lean to neighboring adipose tissue through distances of the order of 1 mm. The diffusional rate of cyclopropane u… Show more

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Cited by 60 publications
(15 citation statements)
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“…The mathematical model based on this perfusionlimited assumption, failed to simulate thetime-course of elimination of inhaled benzene and toluene in men (Sato et al, 1974). For the transfer of fat-soluble compounds direct diffusion between neighbouring tissues, each having different perfusion/partition properties and hence being filled and emptied at a different rate, was found to be a significant pathway in addition to perfusion (Perl et al, 1965). Taking account of this intertissue diffusion, we have assumed that it takes no longer than three hours after exposure has ceased for trichloroethylene to reach an apparent equilibrium and then to be distributed throughout the body according to its partitioning characteristics between blood and tissues.…”
Section: Discussionmentioning
confidence: 98%
“…The mathematical model based on this perfusionlimited assumption, failed to simulate thetime-course of elimination of inhaled benzene and toluene in men (Sato et al, 1974). For the transfer of fat-soluble compounds direct diffusion between neighbouring tissues, each having different perfusion/partition properties and hence being filled and emptied at a different rate, was found to be a significant pathway in addition to perfusion (Perl et al, 1965). Taking account of this intertissue diffusion, we have assumed that it takes no longer than three hours after exposure has ceased for trichloroethylene to reach an apparent equilibrium and then to be distributed throughout the body according to its partitioning characteristics between blood and tissues.…”
Section: Discussionmentioning
confidence: 98%
“…kidney, intestine, dermis) to surrounding adipose tissue [46,51]. Both of these effects also depend on the perfusion/diffusion ratio (eq.…”
Section: Discussionmentioning
confidence: 99%
“…These errors arise from diffusion processes by which ^khypton is exchanged between subcutaneous and cutaneous tissues. Intercompartmental exchange has previously been calculated by Perl et al These authors assumed that the exchange between adjacent tissue compartments was only by diffusion across the boundary between tissues (15)(16)(17)(18)(19) and not by transport via blood streaming between tissues. Observations in the present study, however, indicate that such a blood transport mechanism is also of importance.…”
Section: Discussionmentioning
confidence: 99%