Interval between first dose and booster affected antibody production in cattle vaccinated against rabies

Albas, Avelino; Fontolan, O. L.; Pardo, Paulo Eduardo; Bremer‐Neto, Hermann; Sartori, Alexandrina

doi:10.1590/s1678-91992006000300010

Cited by 6 publications

(7 citation statements)

References 8 publications

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“…The importance of a booster dose was also reported by several researchers (1,2,17,20,21,23), confirming that the immune response induced by only one vaccine dose does not induce high antibody titers. However, when boosters are given, the serum neutralizing antibody titers become significantly higher (1,16).…”

supporting

confidence: 67%

See 1 more Smart Citation

Importance of Antirabies Revaccination for an Adequate Antirabies Protection in Bovine Newborns

Filho

Megid

Geronutti

et al. 2010

Clin Vaccine Immunol

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The transfer of antirabies immunoglobulins in cows that were prime vaccinated and cows that were revaccinated against rabies correlated to the serum titers in their offspring was evaluated. The results demonstrated that revaccination against rabies during pregnancy induces neutralizing antibody titers at a protective level that are transferred directly to calves through colostrum and reinforce the importance of revaccination for improved colostral antibody transfer and offspring protection against rabies.According to the Panamerican Health Organization (16), 2,797 cases of rabies in cattle were reported in 2004 in the Americas, which is an 87% increase over 2002 levels. Of these, 2,591 (92.6%) occurred in Latin America and 130 (4.6%) in North America. In Latin America, Brazil had 60.6% of the cases, followed by 13% in Mexico and 8% in the Andes. More recent data demonstrated that Brazil still reports more cases of rabies in domestic animals than other countries of South America, with a predominance of rabies in cattle (24).

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supporting

confidence: 67%

“…Other researchers have also reported similar results (17,20,21,23), demonstrating that the immune response induced by only one vaccine did not induce high antibody titers; however, when boosters are given, titers become significantly higher (1,2,15).…”

supporting

confidence: 55%

Importance of Antirabies Revaccination for an Adequate Antirabies Protection in Bovine Newborns

Filho

Megid

Geronutti

et al. 2010

Clin Vaccine Immunol

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“…The large-scale and regular vaccination of cattle is an efficient low-cost method that prevents and controls rabies infection, minimizing economic losses (1,4,5).…”

Section: Introductionmentioning

confidence: 99%

Association between handling stress in the corral and rabies antibody titers in selenium-supplemented cattle

Reis¹,

Chiacchio²,

Oba³

et al. 2009

J. Venom. Anim. Toxins incl. Trop. Dis

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This study determined the correlation between serum cortisol levels and rabies antibody titers in cattle primo-vaccinated against rabies and supplemented with dietary selenium (Se). Sixty Nelore male calves (10 to 12 months old) received daily and individual dietary supplementation with 0, 3.6, 5.4 and 6.4 mg Se (groups Gc, G 3.6 , G 5.4 and G 6.4 , respectively). The animals were vaccinated against rabies (day 0) and subjected to handling stress in the corral for 120 days. Blood sampling procedures were performed on days 0, 15, 30, 60, 90 and 120. Cortisol levels increased until day 90, but had dropped significantly by day 120 (P < 0.01). Rabies antibody titers on days 30 and 90 were similar among Sesupplemented groups; in the control group, rabies antibodies decreased significantly from day 30 to 60, and 90 to 120. Serum cortisol levels and antibody titers were not correlated in most of the groups or blood sampling days. A positive correlation among these variables was found only in G 6.4 on days 60 (R = 0.513; P = 0.05) and 120 (R = 0.644; P = 0.009). In conclusion, repeated handling in the corral stresses cattle, but without compromising rabies humoral immune response.

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“…These findings are in agreement with those reported for other vaccines which showed a non-inferior or even a more robust immune response with intervals between vaccine doses up to 7-11 y longer than those recommended by product monographs. [15][16][17][18][19][20][21] These observations do not correlate with higher numbers of memory B-cells at early time points post first-dose administration. However, memory cells are not all equal in their proliferative potential, and the memory of the system matures over time, as cells with high proliferative capacity are generated and/or maintained.…”

Section: Post First Dosementioning

confidence: 83%

Long intervals between two doses of HPV vaccines and magnitude of the immune response: a post hoc analysis of two clinical trials

Gîlca

Sauvageau

Panicker

et al. 2019

Human Vaccines & Immunotherapeutics

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The objective of this analysis was to compare the anti-HPV GMTs and their distribution after a 6-month or a 3-8-y interval between two HPV vaccine doses. The results from two clinical trials, conducted by the same team in the same region, with serological assays performed at the same laboratory using the same ELISA methodology were compared. In the first study, 173 9-10-y-old girls and boys received two doses of 9vHPV vaccine at a 6-month interval; in the second study, 31 girls vaccinated with one dose of 4vHPV at the age of 9-14 y received a dose of 9vHPV 3-8 y later (mean 5.4 y). In both studies, blood samples were collected before and 1 month post second dose. Despite large differences in the time since the first dose, all subjects (100%) were seropositive to the common 4 HPV types (6, 11, 16 and 18) to both vaccines, with comparable GMTs and titer distributions before the second dose. One month post second dose, the GMTs increased 40-91-fold for those with a 6-month interval between doses and 60-82-fold for those with a 3-8-y interval. Titer distributions after the booster dose were comparable in the two studies. These results indicate that 2-dose HPV vaccination schedules with an interval of several years could be used for pre-adolescents. Intervals longer than 6 months may facilitate logistics for immunization programs and could be useful during periods of vaccine shortage or as a transition while the effectiveness of a one-dose schedule is being evaluated.

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Interval between first dose and booster affected antibody production in cattle vaccinated against rabies

Cited by 6 publications

References 8 publications

Importance of Antirabies Revaccination for an Adequate Antirabies Protection in Bovine Newborns

Importance of Antirabies Revaccination for an Adequate Antirabies Protection in Bovine Newborns

Association between handling stress in the corral and rabies antibody titers in selenium-supplemented cattle

Long intervals between two doses of HPV vaccines and magnitude of the immune response: a post hoc analysis of two clinical trials

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