Interval cancers after skin cancer screening: incidence, tumour characteristics and risk factors for cutaneous melanoma

Hübner, Joachim; Waldmann, Annika; Geller, Alan C.; Weinstock, Martin A.; Eisemann, Nora; Noftz, Maria R.; Bertram, Stephanie; Nolte, Sandra; Volkmer, Beate; Greinert, Rüdiger; Breitbart, Eckhard W.; Katalinic, Alexander

doi:10.1038/bjc.2016.390

Cited by 26 publications

(25 citation statements)

References 30 publications

(30 reference statements)

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“…Epidemiological data suggest that fast growing NM more commonly affects men, aged 50+ years, who lack any of the known melanoma risk factors established for other forms of CM such as multiple nevi, freckles or signs of sun-damage [6][7][8]. Notably, the group of people with the highest risk for NM, are also constantly under-represented during skin cancer screening programs [9]. On the other hand, screening programs seem to have little impact on the prompt diagnosis of early NM, as the majority of tumors develop rapidly de novo on previously unaffected skin and are mainly patient detected [10].…”

Section: Epidemiologymentioning

confidence: 99%

Improving the early diagnosis of early nodular melanoma: can we do better?

Corneli

Zalaudek

Rizzi

et al. 2018

Expert Review of Anticancer Therapy

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Cutaneous melanoma is the sixth most common malignant cancer in the USA. Among different subtypes of melanoma, nodular melanoma (NM) accounts about 14% of all cases but is responsible for more than 40% of melanoma deaths. Early diagnosis is the best method to improve melanoma prognosis. Unfortunately, early diagnosis of NM is particularly challenging given that patients often lack identifiable risk factors such as many moles or freckles. Moreover, early NM may mimic a range of benign skin lesions that are not routinely excised or biopsied in every day practice. For this reason, specific clinical and skin imaging clues have been proposed to improve early detection of NM. Areas covered: The review discusses about the noninvasive tools to diagnose thin melanoma, particularly NM. Expert commentary: Currently, dermatologists present a wide opportunity of diagnostic tools. Current data suggest that the early diagnosis of NM is a major challenge as the majority of early NM are symmetric, roundish, and lack specific pattern. Another promising strategy is based on recent data suggesting that artificial intelligence based on deep convolutional neural networking is able to outperform average dermatologist. Further research is necessary to validate the performance of this method in the real world and in the clinical setting.

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Section: Epidemiologymentioning

confidence: 99%

Improving the early diagnosis of early nodular melanoma: can we do better?

Corneli

Zalaudek

Rizzi

et al. 2018

Expert Review of Anticancer Therapy

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“…The GP-based melanoma screening strategy was devised largely on the strength of the SCREEN project conducted in Northern Germany, [19][20][21][22][23] adapting some aspects of the model to make it more compliant with the Veneto healthcare system. In this screening strategy, people aged >20 who were resident in the Veneto Region would receive a mailed invitation, as this is the recruitment scheme already in use for other regional cancer screening programmes.…”

Section: Methodsmentioning

confidence: 99%

“…Table 1 shows the screening-related variables, which were derived from the SCREEN pilot project. [19][20][21][22][23] We developed a Markov model using TreeAge Pro 2011 over a time horizon of 25 years, to compare costs and outcomes with and without (usual care) screening (Figure 1(a) to (c)). In this study, we focused only on cases of melanoma detectable during the one-time screening campaign, and followed them over a time horizon of 25 years.…”

Section: Methodsmentioning

confidence: 99%

Cost-effectiveness of a melanoma screening programme using whole disease modelling

et al. 2019

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Objective To assess the potential impact of a melanoma screening programme, compared with usual care, on direct costs and life expectancy in the era of targeted drugs and cancer immunotherapy. Methods Using a Whole Disease Model approach, a Markov simulation model with a time horizon of 25 years was devised to analyse the cost-effectiveness of a one-time, general practitioner-based melanoma screening strategy in the population aged over 20, compared with no screening. The study considered the most up-to-date drug therapy and was conducted from the perspective of the Veneto regional healthcare system within the Italian National Health Service. Only direct costs were considered. Sensitivity analyses, both one-way and probabilistic, were performed to identify the parameters with the greatest impact on cost-effectiveness, and to assess the robustness of our model. Results Over a 25-year time horizon, the screening intervention dominated usual care. The probabilistic sensitivity analyses confirmed the robustness of these findings. The key drivers of the model were the proportion of melanomas detected by the screening procedure and the adherence of the target population to the screening programme. Conclusions The screening programme proved to be a dominant option compared with usual care. These findings should prompt serious consideration of the design and implementation of a regional or national melanoma screening strategy within a National Health Service.

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“…Cutaneous melanoma causes around 90% of deaths in skin cancer patients [54]. The incidence has risen steadily worldwide over the last decades [55]. The incidence is increasing annually, and is currently 19.5 for men and 20.9 for women per 100,000 populations (World Standard Population year 2000) [56].…”

Section: Pharmacological Effectsmentioning

confidence: 99%

A Potential Anti-Tumor Herb Bred in a Tropical Fruit: Insight into the Chemical Components and Pharmacological Effects of Momordicae Semen

Luo

Cao

et al. 2019

Molecules

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Gac fruit (Momordica cochinchinensis Spreng) is a popular tropical fruit in southeast Asia. What is amazing is that its seeds (Momordicae Semen) and arils are traditional herbs with anti-tumor activity, and have protected human health for more than 1000 years. In recent years, its anti-tumor activity has received extensive attention and research. This manuscript summarized the chemical composition of saponins, fatty acids, volatile constituents, proteins, peptides, and other components from Momordicae Semen (MSE). The effect and mechanism of MSE and its extract on breast cancer, gastric cancer, lung cancer, esophagus cancer, melanomas, and human cervical epithelial carcinoma were discussed. In addition, its antioxidant, anti-inflammatory, and other pharmacological effects were also analyzed. We hope that this review will provide new ideas for the treatment of cancer and other diseases, and become a reference for the further research into complementary and alternative medicine.

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Interval cancers after skin cancer screening: incidence, tumour characteristics and risk factors for cutaneous melanoma

Cited by 26 publications

References 30 publications

Improving the early diagnosis of early nodular melanoma: can we do better?

Improving the early diagnosis of early nodular melanoma: can we do better?

Cost-effectiveness of a melanoma screening programme using whole disease modelling

A Potential Anti-Tumor Herb Bred in a Tropical Fruit: Insight into the Chemical Components and Pharmacological Effects of Momordicae Semen

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