Interval Neurophysiological Changes in Non Septic Critically Ill Mechanically Ventilated Patients

El‐Salem, Khalid; Khassawneh, Basheer; Alrefai, Ali; Dwairy, Abdel Raheem; Rawashdeh, Sukaina I.

doi:10.1097/wnp.0b013e318262447e

Cited by 2 publications

(3 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…27 In sALS, a lower IENF density could represent the synergy of two processes: the physiological loss and the loss associated with ALS. 28–31…”

Section: Discussionmentioning

confidence: 99%

“…27 In sALS, a lower IENF density could represent the synergy of two processes: the physiological loss and the loss associated with ALS. [28][29][30][31] Weis et al, 2011, conducted the first study that also evaluated IENF density by skin biopsy in patients with sALS. 11 Similar to our ALS8 data, their data showed a lower IENF density in ALS8 patients than in controls, but they also found an inverse correlation with increasing age that was not found in our study.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Small-fibre Neuropathy in Patients with Familial Amyotrophic Lateral Sclerosis Type 8

Machado‐Costa

Mitne‐Neto

Costa

et al. 2022

Can. J. Neurol. Sci.

View full text Add to dashboard Cite

Background: Amyotrophic lateral sclerosis (ALS) is a degenerative disease of the nervous system that primarily affects motor neurons. ALS type 8 (ALS8) is a familiar form with predominant involvement of lower motor neurons, tremor, and slow progression. Objective: The aim of this study was to describe sensory involvement in a cohort of ALS8 patients and compare it with the characteristics of sporadic ALS (sALS) patients and controls. Methods: We compared data from 40 ALS8 and 10 sALS patients assessed by neurological evaluation and electrophysiological study. Skin biopsies were performed in these patients and 12 controls for analysis of intraepidermal nerve fiber (IENF) density by protein gene product 9.5 (PGP 9.5) immunohistochemistry. Results: The ALS8 group was younger than the sALS group at the onset of symptoms (p < 0.05) and had a longer disease evolution (p < 0.01). Sensory abnormalities were evident in 35% of the ALS8 and 30% of the sALS patients by neurological examination, and all ALS patients presented normal sensory nerve action potentials. Despite being similar in the ALS8 and sALS groups, IENF density in the ALS8 group was lower than that in the controls (p < 0.0005). In the ALS8 group, IENF density was significantly lower in patients with impairment of vibratory sensation than in those without this finding (p < 0.05) and in females than in males (p < 0.05). Conclusion: Sensory impairment and decreased IENF density are present in ALS8 patients at a frequency and intensity similar to that in the sALS group.

show abstract

“…27 In sALS, a lower IENF density could represent the synergy of two processes: the physiological loss and the loss associated with ALS. 28–31…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Small-fibre Neuropathy in Patients with Familial Amyotrophic Lateral Sclerosis Type 8

Machado‐Costa

Mitne‐Neto

Costa

et al. 2022

Can. J. Neurol. Sci.

View full text Add to dashboard Cite

show abstract

“…Furthermore, a standardized clinical assessment of the patient’s neuromuscular function was performed. The MRC-SS was assessed on day 3 and 10 and ICU-AW was diagnosed in patients achieving < 48 points 5 . A sedation holiday of at least 2 h before examination was performed in all patients with mechanical ventilation and continuous analgosedation.…”

Section: Methodsmentioning

confidence: 99%

A novel ex vivo model for critical illness neuromyopathy using freshly resected human colon smooth muscle

Patejdl

Klawitter

Walter

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Patients suffering from critical illness are at risk to develop critical illness neuromyopathy (CINM). The underlying pathophysiology is complex and controversial. A central question is whether soluble serum factors are involved in the pathogenesis of CINM. In this study, smooth muscle preparations obtained from the colon of patients undergoing elective surgery were used to investigate the effects of serum from critically ill patients. At the time of blood draw, CINM was assessed by clinical rating and electrophysiology. Muscle strips were incubated with serum of healthy controls or patients in organ baths and isometric force was measured. Fifteen samples from healthy controls and 98 from patients were studied. Ratios of responses to electric field stimulation (EFS) before and after incubation were 118% for serum from controls and 51% and 62% with serum from critically ill patients obtained at day 3 and 10 of critical illness, respectively (p = 0.003, One-Way-ANOVA). Responses to carbachol and high-K+ were equal between these groups. Ratios of post/pre-EFS responses correlated with less severe CINM. These results support the existence of pathogenic, i.e. neurotoxic factors in the serum of critically ill patients. Using human colon smooth muscle as a bioassay may facilitate their future molecular identification.

show abstract

Interval Neurophysiological Changes in Non Septic Critically Ill Mechanically Ventilated Patients

Cited by 2 publications

References 23 publications

Small-fibre Neuropathy in Patients with Familial Amyotrophic Lateral Sclerosis Type 8

Small-fibre Neuropathy in Patients with Familial Amyotrophic Lateral Sclerosis Type 8

A novel ex vivo model for critical illness neuromyopathy using freshly resected human colon smooth muscle

Contact Info

Product

Resources

About