Intervalos de referencia de la tirotropina durante la gestación en la provincia de Huelva

Carpio, Alejandro; Rico, Ignacio Vázquez; López, Miguel Ángel Castaño; González, L. Duarte; Alvaro, Meana; Reina, A. Ruiz

doi:10.1016/j.semerg.2017.08.008

Cited by 6 publications

(4 citation statements)

References 25 publications

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“…Table 4 summarizes the characteristics of the eight longitudinal studies published before the present paper, between January 2010 and December 2021, which calculated the reference intervals of thyroid function in pregnancy: five employed Roche, three employed Abbott, two employed Beckman, and one employed Siemens instrumentation [13][14][15][16][17][18][19][20]. Three of them (two using Roche and one Abbott) did not include FT3 results.…”

Section: Resultsmentioning

confidence: 99%

“…It is noteworthy that iodine intake has been poorly investigated in the past. Indeed, urinary iodine has not been measured in many studies summarized in Table 4 [14][15][16]19] or, when measured, has not been assayed with reference technology [13,20]. In studies reported in the review by Medici et al, it was sufficient only in two of the investigated cohorts and mild-moderately insufficient in all other studies [29].…”

Section: Discussionmentioning

confidence: 99%

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Trimester-specific reference intervals for thyroid function parameters in pregnant Caucasian women using Roche platforms: a prospective study

Dorizzi

Spiazzi

Rolli

et al. 2023

J Endocrinol Invest

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Background Standard thyroid function parameters reference intervals (RI) are unsuitable during pregnancy, potentially resulting in incongruous treatments that may cause adverse effects on pregnancy outcomes. We aimed at defining trimester-specific TSH, FT4 and FT3 RI, using samples longitudinally collected from healthy Caucasian women. Materials and methods Blood samples from 150 healthy Caucasian women, who had a physiological gestation and a healthy newborn at term, were collected in each trimester and at around six months post-partum. They showed mild iodine deficiency. After excluding women with overt TSH abnormalities (> 10 mU/L) and/or TPO antibodies, data from 139 pregnant women were analyzed by means of widely used Roche platforms, and TSH, FT4 and FT3 trimester-specific RI were calculated. Post-partum data were available for 55 subjects. Results Serum TSH RI were 0.34–3.81 mU/L in the first trimester, and changed slightly to 0.68–4.07 U/L and 0.63–4.00 mU/L in the second and third trimester, respectively. Conversely, both FT4 and FT3 concentrations progressively decreased during pregnancy, the median values in the third trimester being 14.8% and 13.2% lower, respectively, than in the first trimester. Thyroid function parameters in the first trimester were similar to those measured after the end of pregnancy. Conclusions This study calculates trimester-specific RI for thyroid function parameters in pregnancy, and proposes the reference limits that should be adopted when using Roche platforms in Caucasian women.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Trimester-specific reference intervals for thyroid function parameters in pregnant Caucasian women using Roche platforms: a prospective study

Dorizzi

Spiazzi

Rolli

et al. 2023

J Endocrinol Invest

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“…Consecuentemente, las diferentes sociedades científicas han buscado establecer rangos de referencia específicos para cada trimestre (tabla 1). La recomendación actual es la de utilizar, siempre que sea posible, los rangos de referencia de TSH sérico específicos para la población y trimestre (19,(23)(24)(25) .…”

Section: Modificaciones En El Metabolismo Periféricounclassified

“…Diversas sociedades han tratado de establecer rangos de referencias que se ajusten a todas las poblaciones, aunque preferiblemente se debe contar con valores propios (19,23,24) . A nivel mundial ya se cuenta con estudios de esta clase (20,22,25,28) . En nuestro país, es necesario incitar este tipo de investigaciones para lograr estrategias de detección precisa y apropiada para las características propias de nuestra población.…”

Section: Conclusionesunclassified

Hipertiroidismo en el embarazo

Franco-Herrera

Diaz

Ocampo

et al. 2018

Rev peru ginecol obstet.

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La relación hipertiroidismo y embarazo es poco común. Su importancia recae en el pronóstico de la madre y el feto. El reconocimiento de las alteraciones tiroideas durante el embarazo difiere de la población general. En este grupo poblacional es necesario correlacionar las pruebas diagnósticas con los cambios fisiológicos durante este periodo. La principal causa de hipertiroidismo es la enfermedad de Graves, consu componente autoinmune. La tirotoxicosis gestacional transitoria toma relevancia durante el embarazo y es un diagnóstico diferencial importante durante el primer trimestre. El manejo del hipertiroidismo durante el embarazo tiene implicaciones especiales. Las terapias de primera línea convencionales están contraindicadas, y toman relevancia los medicamentos antitiroideos. Ninguna terapia es totalmentesegura durante el embarazo y se deben evaluar los posibles efectos adversos e implicaciones para la madre y el feto. En esta revisión queremos dar a conocer los cambios en la función tiroidea durante la gestación; además, las pautas necesarias para el adecuado reconocimiento, diagnóstico y manejo del hipertiroidismo durante el embarazo, con el fin de disminuir la morbilidad y mortalidad materno-fetal. Se realizó una revisión de la literatura en PubMed y Science Direct utilizando palabras MeSH y conectores. Se incluyeron artículos especiales más relevantes publicados por las sociedades internacionales en los últimos 20 años sobre el diagnóstico y manejo del hipertiroidismo durante el embarazo.

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Reference TSH levels in Spanish pregnant women. Is it possible to unify criteria?

Candil

Alday

Álvarez-García

2019

Endocrinología, Diabetes y Nutrición (English ed.)

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Intervalos de referencia de la tirotropina durante la gestación en la provincia de Huelva

Cited by 6 publications

References 25 publications

Trimester-specific reference intervals for thyroid function parameters in pregnant Caucasian women using Roche platforms: a prospective study

Trimester-specific reference intervals for thyroid function parameters in pregnant Caucasian women using Roche platforms: a prospective study

Hipertiroidismo en el embarazo

Reference TSH levels in Spanish pregnant women. Is it possible to unify criteria?

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