Intervention of Vine Tea Extract on Non-alcoholic Fatty Liver in Mice

Abstract

To investigate the effects of vine tea extract (VTE) on high-fat-diet (HFD) induced obesity in mice. A C57BL/6J mouse model of obesity induced by 8-week high-fat diet was established. By measuring the activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and the contents of triglyceride (TG), total cholesterol (T-CHO), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) in serum. Pathological changes were observed by H&E staining to explore the effect of VTE on obese mice. The results showed that, compared with the model group, the levels of AST, ALT, TG, T-CHO, LDL-C in serum were significantly decreased, while the levels of HDL-C in serum was increased in the VTE low and high dose groups. It also improved fat vacuoles, inflammatory infiltration, and inflammatory response in liver tissue. In conclusion, VTE may improve lipid metabolism in HFD-induced obese mice by inhibiting oxidative stress and inflammatory response.