“…Because arterial thromboembolic events are often emergencies that result in pain, ischemia, and tissue damage, antiplatelet drugs are of limited value for treatment of acute arterial thromboembolic events in veterinary patients. 44,46 Systemic urokinase, streptokinase, and tPA have been used with varying effectiveness in cats with aortic thromboembolism (ATE), in dogs with ATE, and in a femoral arterial obstruction in a dog. [58][59][60][61][62][63][64][65][66][67][68][69][70] Local administration of tPA in a cat with ATE and a Greyhound with ATE secondary to protein-losing nephropathy has been described, with both cases having return of motor function in their limbs and survival to discharge.…”