Interventional management of tracheobronchial strictures

Shin, Ji Hoon

doi:10.4329/wjr.v2.i8.323

Cited by 18 publications

(7 citation statements)

References 25 publications

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“…A variety of interventional bronchoscopic techniques have recently been used to treat airway stenosis. This approach produced some beneficial effects, but airway restenosis occurred in some of the patients [1,2,3,9,10,11,13,14]. Reported data show a rate of restenosis from 40 to 70% [36].…”

Section: Discussionmentioning

confidence: 99%

“…Airway granulation hyperplasia and scar formation have been found to be the main component of airway restenosis [1,2,3,4]. A variety of interventional bronchoscopic techniques have recently been used to treat airway stenosis.…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, this kind of intervention tends to entail recurrent stenosis due to granulation tissue formation. The repeated procedures required [1,2,3,9,10,11,13,14] make airway stenosis a clinical challenge. Therefore, exploring new treatments is important for better clinical outcomes.…”

Section: Introductionmentioning

confidence: 99%

“…Airway stenosis patients have dyspnea and a lower quality of life [1,2,3,4]. Current treatments include surgery, drugs, and interventional bronchoscopic techniques [1,2,3,5,6,7,8,9,10].…”

Section: Introductionmentioning

confidence: 99%

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Inhibitory Effect of β-Elemene on Human Airway Granulation Tissue in vivo and in vitro

Li¹,

Zeng

Yang

2016

Respiration

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Background: Recurrent airway granulation hyperplasia and scar formation make airway stenosis a clinical challenge. Therefore, a new approach for the treatment of airway stenosis is necessary. Objective: To explore the inhibitory effect of β-elemene on the proliferation of fibroblasts and airway granulation. Methods: In vivo: (1) study of the effect of local β-elemene injection by bronchoscopy. (2) During bronchoscopy, granulation tissues both before and after treatment were obtained. HE staining was performed and the result compared. In vitro: (1) human airway primary fibroblasts were purified and characterized. (2) Fibroblasts were treated with β-elemene and normal saline (NS) and then examined by optical and electron microscopy. (3) Fibroblasts treated with β-elemene or NS were assessed for viability by tetrazolium salt assay. (4) Apoptotic rates were determined by flow cytometry. Results: In vivo: (1) after local injection of β- elemene, airway granulation tissue was reduced. (2) Granulation tissue was found to have less edema, and fibroblasts turned into mature fiber cells. In vitro: (1) human airway primary fibroblasts were successfully purified and cultured. (2) Compared with the control group, fibroblasts of the experimental group became clumped, the plasma granules were increased, and some fibroblasts lost their nucleus and organelles. (3) Compared with the control group, reduction of cell viability was detected with increased concentrations of β-elemene. (4) With increased concentrations of β-elemene, apoptotic rates of the fibroblasts were raised compared with the control group. Conclusions: β-Elemene may induce apoptosis and necrosis of airway primary fibroblasts and inhibit the proliferation of fibroblasts and airway granulation. The results provide a new approach for the treatment of airway stenosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Airway stenosis patients have dyspnea and a lower quality of life [1,2,3,4]. Current treatments include surgery, drugs, and interventional bronchoscopic techniques [1,2,3,5,6,7,8,9,10].…”

Section: Introductionmentioning

confidence: 99%

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Inhibitory Effect of β-Elemene on Human Airway Granulation Tissue in vivo and in vitro

Li¹,

Zeng

Yang

2016

Respiration

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“…Nevertheless, restenosis remains unavoidable in some patients, usually resulting in a poor prognosis10. Therefore, developing new therapeutic strategy is required.…”

mentioning

confidence: 99%

A canine model of tracheal stenosis induced by cuffed endotracheal intubation

Zhou

et al. 2017

Sci Rep

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Postintubation tracheal stenosis is a complication of endotracheal intubation. The pathological mechanism and risk factors for endotracheal intubation-induced tracheal stenosis remain not fully understood. We aimed to establish an animal model and to investigate risk factors for postintubation tracheal stenosis. Beagles were intubated with 4 sized tubes (internal diameter 6.5 to 8.0 mm) and cuff pressures of 100 to 200 mmHg for 24 hr. The status of tracheal wall was evaluated by bronchoscopic and histological examinations. The model was successfully established by cuffed endotracheal intubation using an 8.0 mm tube and an intra-cuff pressure of 200 mmHg for 24 hr. When the intra-cuff pressures were kept constant, a larger sized tube would induce a larger tracheal wall pressure and more severe injury to the tracheal wall. The degree of tracheal stenosis ranged from 78% to 91% at 2 weeks postextubation. Histological examination demonstrated submucosal infiltration of inflammatory cells, hyperplasia of granulation tissue and collapse of tracheal cartilage. In summary, a novel animal model of tracheal stenosis was established by cuffed endotracheal intubation, whose histopathological feathers are similar to those of clinical cases of postintubation tracheal stenosis. Excessive cuff pressure and over-sized tube are the risk factors for postintubation tracheal stenosis.

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Is Long-Term Stenting for Benign Airway Obstruction Effective?

Bhora¹,

Baig²

2020

Difficult Decisions in Surgery: An Evidence-Based Approach

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Interventional management of tracheobronchial strictures

Cited by 18 publications

References 25 publications

Inhibitory Effect of β-Elemene on Human Airway Granulation Tissue in vivo and in vitro

Inhibitory Effect of β-Elemene on Human Airway Granulation Tissue in vivo and in vitro

A canine model of tracheal stenosis induced by cuffed endotracheal intubation

Is Long-Term Stenting for Benign Airway Obstruction Effective?

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