Interventionelle Kombinationstherapien

Abstract

Interventional tumor therapies are a therapeutic option that is increasingly applied in the treatment of malignant diseases. Thermoablation of primary and secondary liver tumors is the most widely used of them, and owing to the promising results it has given, it is becoming an increasingly well-accepted treatment procedure. These interventional radiological tumor therapies must be evaluated in comparison with standard therapies, and particularly in comparison with surgical resection, radiotherapy, and systemic chemotherapy. This comparative approach to the evaluation of different therapies is reflected in the current literature. Besides this approach, interdisciplinary combination of therapies is a promising approach to the optimization of oncological therapy strategies. Local thermoablation in association with systemic or local chemotherapy, and surgical resection in association with thermoablation are interdisciplinary therapy concepts that expand the range of therapeutic options available. Against this backdrop, studies to evaluate interventional tumor therapies as part of interdisciplinary combination therapies are necessary.

Multimodality Treatment with Conventional Transcatheter Arterial Chemoembolization and Radiofrequency Ablation for Unresectable Hepatocellular Carcinoma

“…Researchers hypothesized that blood flow occlusion in the tumor can decrease heat dispersion by the bloodstream, and increase the size of the necrotic area produced with ablation [21,32]. …”

“…On the other hand, TACE induces an ischemic necrosis by using antitumor drugs and embolizing agents and prolongs survival [18,19]. Evidence suggests that TACE combined with RFA have a synergistic effect [20,21] in treating HCC and is superior to TACE or RFA alone in terms of the effect of survival [22,23]. The decrease of blood flow in the HCC lesion by TACE appears to increase the efficacy of RFA in destroying tumors.…”