Interventions for cough in malignant disease

Molassiotis, Alex; Bailey, Chris; Caress, Ann Louise; Brunton, Lisa

doi:10.1002/14651858.cd007881

Cochrane Database of Systematic Reviews 2009

DOI: 10.1002/14651858.cd007881

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Interventions for cough in malignant disease

Alex Molassiotis

Chris Bailey

Ann Louise Caress

et al.

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2010

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Clinical expert guidelines for the management of cough in lung cancer: report of a UK task group on cough

Molassiotis

Smith

Bennett

et al. 2010

Cough

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BackgroundCough is a common and distressing symptom in lung cancer patients. The clinical management of cough in lung cancer patients is suboptimal with limited high quality research evidence available. The aim of the present paper is to present a clinical guideline developed in the UK through scrutiny of the literature and expert opinion, in order to aid decision making in clinicians and highlight good practice.MethodsTwo systematic reviews, one focusing on the management of cough in respiratory illness and one Cochrane review specifically on cancer, were conducted. Also, data from reviews, phase II trials and case studies were synthesized. A panel of experts in the field was also convened in an expert consensus meeting to make sense of the data and make clinical propositions.ResultsA pyramid of cough management was developed, starting with the treatment of reversible causes of cough/specific pathology. Initial cough management should focus on peripherally acting and intermittent treatment; more resistant symptoms require the addition of (or replacement by) centrally acting and continuous treatment. The pyramid for the symptomatic management starts from the simpler and most practical regimens (demulcents, simple linctus) to weak opioids to morphine and methadone before considering less well-researched and experimental approaches.ConclusionThe clinical guidelines presented aim to provide a sensible clinical approach to the management of cough in lung cancer. High quality research in this field is urgently required to provide more evidence-based recommendations.

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Clinical expert guidelines for the management of cough in lung cancer: report of a UK task group on cough

Molassiotis

Smith

Bennett

et al. 2010

Cough

Self Cite

View full text Add to dashboard Cite

show abstract

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Interventions for cough in malignant disease

Cited by 1 publication

References 14 publications

Clinical expert guidelines for the management of cough in lung cancer: report of a UK task group on cough

Clinical expert guidelines for the management of cough in lung cancer: report of a UK task group on cough

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