Interventions for managing medication-related osteonecrosis of the jaw

Beth-Tasdogan, Natalie H; Mayer, Benjamin; Hussein, Heba; Zolk, Oliver; Peter, Jens-Uwe

doi:10.1002/14651858.cd012432.pub3

Cited by 53 publications

(55 citation statements)

References 94 publications

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“…There is a robust level of support for early screening and initiation of appropriate dental care prior to the initiation of antiresorptive therapy. 38,[182][183][184][185][186] These preventive management strategies not only decrease the risk for MRONJ but accrue the benefits that all patients enjoy with optimum oral health. [186][187][188][189][190][191][192][193] In a prospective study of prostate cancer patients with bone metastasis, instituting a more regimented dental health surveillance system resulted in a 2.5fold reduction in relative risk compared to symptomatically driven dental treatment.…”

Section: Optimization Of Oral Healthmentioning

confidence: 99%

“…There is widespread consensus that optimizing dental health prior to initiating therapy is efficacious and of paramount importance. 38,185,186,209 Medical oncologists should educate their patients about the importance of dental health and the efficacy of prophylactic dental treatment in the prevention of MRONJ. Similar to patients who are to receive radiation therapy, optimizing the dental health in patients receiving antiresorptives or other therapies that can compromise bone healing is essential.…”

Section: Patients Scheduled To Initiate Antiresorptive Treatment For ...mentioning

confidence: 99%

“…This level of care must be continued on a frequent and indefinite basis. 185 The posterior lingual plate region is a common site for trauma and mucosal irritation in denture wearers. 5,75,170 Therefore, patients with full or partial dentures should be examined for areas of mucosal trauma, especially along the lingual flange region.…”

Section: Patients Scheduled To Initiate Antiresorptive Treatment For ...mentioning

confidence: 99%

See 2 more Smart Citations

American Association of Oral and Maxillofacial Surgeons’ Position Paper on Medication-Related Osteonecrosis of the Jaws—2022 Update

Ruggiero

Dodson

Aghaloo

et al. 2022

Journal of Oral and Maxillofacial Surgery

528

599

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Section: Optimization Of Oral Healthmentioning

confidence: 99%

Section: Patients Scheduled To Initiate Antiresorptive Treatment For ...mentioning

confidence: 99%

Section: Patients Scheduled To Initiate Antiresorptive Treatment For ...mentioning

confidence: 99%

See 1 more Smart Citation

American Association of Oral and Maxillofacial Surgeons’ Position Paper on Medication-Related Osteonecrosis of the Jaws—2022 Update

Ruggiero

Dodson

Aghaloo

et al. 2022

Journal of Oral and Maxillofacial Surgery

528

599

View full text Add to dashboard Cite

“…Against the background of several diseases with the potential to cause complications during dental interventions, e.g. antithrombotic medication with related risk for bleeding complications, risk for infective endocarditis or medication-related osteonecrosis of the jaw [2][3][4][5], risk classification appears mandatory in dental practice. Moreover, the association between oral and systemic health has been repeatedly highlighted, whereby different general medical conditions, e.g.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of an individual anamnesis tool for teaching risk-oriented prevention – a pilot study in undergraduate dental students

et al. 2022

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Background A comprehensive medical history is needed to establish and ensure a high standard in dental care; however, it is challenging to draw clinical consequences on the variety of potential diseases and medications, especially for dental students. Aim of this observational study was to investigate, whether undergraduate dental students using an analog anamnesis tool for risk classification would be more confident and have more knowledge in risk classification than other students in the same year of study. Methods A cohort of 48 fifth year dental students was included and allocated into two groups based on their curriculum-related division (group A: n = 25, group B: n = 23). Group A received a teaching event and provision of an analog anamnesis tool for risk classification; group B received neither a teaching event nor the anamnesis tool. At baseline and after two weeks (follow-up), questionnaires regarding self-perceived confidence with risk classification, questions on different disease, medications and lifestyle factors and a task with 15 medical histories of prepared patient cases were applied. The data was statistically analyzed using Mann–Whitney or Wilcoxon test. Results In group comparison of the differences between baseline and follow-up regarding self-perceived confidence, significantly higher improvement was noted in group A compared to group B for all questions (p < 0.05). With regard to knowledge, the group comparison revealed that the differences in all of the four tasks were significantly higher in group A compared to group B (pi ≤ 0.01). Thereby, the different tasks in group A differed between baseline and follow-up as follows: Risk of complications: 49.04 ± 13.59 vs. 67.96 ± 17.22, p < 0.01, Risk of oral diseases: 48.77 ± 13.57 vs. 63.44 ± 16.78, p = 0.01, Indication of antibiotic prophylaxis: 75.70 ± 13.45 vs. 87.97 ± 10.37, p < 0.01 and the Medical history task on 15 patient cases: 58.45 ± 4.74 vs. 71.47 ± 9.54, p < 0.01. Conclusion The applied analog anamnesis tool supported an increase in students´ confidence with issues related to at-risk patients alongside with their knowledge in risk classification. The applied anamnesis tool can be recommended for improving teaching of risk management for undergraduate dental students.

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“…Recent research has focused on identifying the risk factors that dentists and physicians need to be aware of in these patients. Recent data have shed the light on some guidelines that can be useful to both dentists and physicians in dealing with MRONJ patients or with patients at risk [2], [5].…”

Section: Introductionmentioning

confidence: 99%

Medication-Related Osteonecrosis of the Jaw: A Reflection of Current Preventative and Therapeutic Guidelines: A Review

Dib

Khalil

Jassar

et al. 2022

EJDENT

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Medication-related osteonecrosis of the jaw (MRONJ) is a serious side effect of bisphosphonates, denosumab, and antiangiogenic drugs. Although the literature is rich with research work discussing MRONJ, the pathogenesis of this devastating condition has not been adequately understood yet. Roles of infection, immunity and genetic predisposition have been extremely unclear. Moreover, many controversies have been governing risk assessment and management guidelines. In 2003, 36 cases of osteonecrosis of the jaw (ONJ) associated with the use of either pamidronate or zoledronate were reported. Furthermore, in 2014, the American Association of Oral and Maxillofacial Surgeons (AAOMS) suggested the term “medication-related osteonecrosis of the jaw” (MRONJ) to describe jaw osteonecrosis related to the use of medications. This review sheds the light on recent research work discussing the pathogenesis of MRONJ. Moreover, it suggests possible guidelines for risk assessment and management based on information gathered from different research papers found in the literature.

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Interventions for managing medication-related osteonecrosis of the jaw

Cited by 53 publications

References 94 publications

American Association of Oral and Maxillofacial Surgeons’ Position Paper on Medication-Related Osteonecrosis of the Jaws—2022 Update

American Association of Oral and Maxillofacial Surgeons’ Position Paper on Medication-Related Osteonecrosis of the Jaws—2022 Update

Evaluation of an individual anamnesis tool for teaching risk-oriented prevention – a pilot study in undergraduate dental students

Medication-Related Osteonecrosis of the Jaw: A Reflection of Current Preventative and Therapeutic Guidelines: A Review

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