Interventions for preventing delirium in hospitalised non-ICU patients

Abstract

This is a repository copy of Interventions for preventing deliriumin hospitalised non-ICU patients.

Preventive Effects of Suvorexant on Delirium

“…Frequency and duration of each patient were determined using the average of data during study drug administration. Subjective quality of sleep (very good [1], fairly good [2], fairly bad [3], very bad [4]) was determined using the median of data during study drug administration. Data of the night on which delirium appeared were excluded.…”

“…2 Further increase seems likely with the increase in the aged population. Despite some success of multicomponent nonpharmacologic interventions, 3,4 no highly effective pharmacologic interventions to prevent delirium have been identified. Almost all trials of cholinesterase inhibitors failed, 2 and effects of antipsychotics are controversial.…”

Forward thinking: where next for delirium prevention research?

“…Thankfully the landscape is changing, and an updated Cochrane Review provides a nice summary of what we know and gives some pointers as to where we need to go with delirium prevention research. [4] It is generally accepted that prevention is better than cure. This adage is particularly pertinent to delirium and emphasizes the importance of the prevention focus in this review.…”

“…[6] This scope of this review is broad, and the authors are to be congratulated for presenting a synthesis of such a complex area. [4] Of the various interventions described in the review, many have been evaluated in trials that are underpowered or have serious methodological limitations. However, the results concerning multicomponent interventions and certain pharmacological interventions are more compelling and have clear implications for policy and practice.…”

Cochrane Dementia Group Turns 21—Older and (Slightly) Wiser

“…multicomponent interventions to prevent delirium. 19 Psychosocial interventions can also come with vested interests and have lagged behind drug trials in the quality of trial design and reporting (although the landscape is changing). Hence, Cochrane's systematic review methods, emphasising the importance of assessing risk of bias, are just as pertinent.…”