Interventions for reducing inflammation in familial Mediterranean fever

Abstract

There were limited randomized controlled studies assessing interventions for people with familial Mediterranean fever. Based on the evidence, colchicine appears to reduce the number of people experiencing attacks; however, only a few low-quality randomized controlled studies contributed data for analysis. Further randomized controlled studies examining active interventions, not only colchicine, are necessary before a comprehensive conclusion regarding the efficacy and safety of interventions for reducing inflammation in familial Mediterranean fever can be drawn.

Familial Mediterranean Fever (FMF): Mysterious Presentations and Challenging Points From Diagnosis to Management in Acute Care Settings; A Literature Review

“…These findings are useful for better diagnosis and treatment. 4,13,[47][48][49][50] Furthermore, FMF has recently been associated with the angiotensin-converting enzyme gene in Turkish patients. 42 Today, physicians still need to know more about FMF.…”

Abdominal pain in the emergency department: the importance of history taking for common clinical presentations

“…Colchicine may be used to resolve acute attacks, which are usually self‐limited, but is most effective when used continuously for prevention. As prophylaxis, colchicine completely (60%) or partially (30%) prevents attacks in up to 90% of cases . Colchicine‐resistant cases are uncommon and are usually related to missed doses or non‐adherence.…”

Nursing Approach to Child with Familial Mediterranean Fever

“…Ayrıca günde 3 kez 0,6 mg oral kolşisin dozu almanın hastalığın yönetiminde etkili olabileceği bildirilmiştir. 40 Kolşisinin dozu 1-2 mg/gün olarak önerilmekte ve gebelik ve emzirme döneminde kullanımında bir sakınca bulunmamaktadır. Renal amiloidoz geliştiğinde kolşisin dozu 2 mg/gün olarak ayarlanmaktadır.…”

“…Hastalar kolşisin kullanmadan önce 40 yaşını geçtiklerinde, amiloidoz, hastalarının yaklaşık %60'ında görülmekte ve ölümle sonuçlanabilmektedir. 40 Bu durumda renal amiloidoz 4 dönemde karşımıza çıkmaktadır. Bunlar; preklinik dönem, aralıklı veya sürekli proteinüri dönemi, nefrotik sendromun geliştiği dönem ve kronik böbrek yetmezliği dönemi olarak sıralanmaktadır.…”