Interventions for rosacea

Health-related Quality of Life in Patients with Cutaneous Rosacea: A Systematic Review

“…According to van Zuuren et al, there is an urgent need for well-designed studies of several treatments on rosacea (1). Future trials should include HRQoL assessment as primary outcome (1).…”

“…In the 2011 update of the Cochrane Review of interventions for rosacea, HRQoL was considered to be the most important outcome parameter (1). In a number of studies, including clinical trials, the impact of rosacea on HRQoL has been described (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13).…”

“…Although there is no cure for this disease, several topical as well as oral medications have proven effective in temporarily reducing signs and symptoms (1,(22)(23)(24).…”

Topical kanuka honey for the treatment of rosacea

“…This is important because a substantial placebo effect was found in rosacea trials of metronidazole cream. 2 Thus, the honey-specific effect size may have been overestimated in this study, although it was useful to find that participant-and investigator-assessed severity had similar degrees of variance.…”

Democratizing the Clinical Trials Agenda in Dermatology

“…Small trials are trickier to address. Time and time again, when systematic reviews of skin disease treatments are prepared by the Cochrane Collaboration, the same predictable results emerge-around 30 underpowered and highly heterogeneous RCTs, most of which are at high risk of bias because of unclear description of key elements such as randomization, blinding, and loss to follow-up (Whitton et al, 2010;van Zuuren et al, 2011). Typically, these reviews end up with that frustrating conclusion "insufficient evidence" or that vacuous phrase "more research is needed," which, although true, is of little use to clinicians.…”