Interventions for the prevention of acute phase chemotherapy-induced nausea and vomiting in adult and pediatric patients: a systematic review and meta-analysis

Patel, Priya; Robinson, Paula D.; Wahib, Nora; Cheung, P.W.; Wong, Teng-fong; Cabral, Sandra; Parker, Arden; Cohen, Marie; Devine, Katie A.; Gibson, Paul; Holdsworth, Mark T.; Neumann, Eloise; Orsey, Andrea; Phillips, Bob; Spinelli, Daniela; Thackray, Jennifer; Wetering, Marianne van de; Woods, Deborah; Sung, Lillian; Dupuis, L. Lee

doi:10.1007/s00520-022-07287-w

Cited by 12 publications

(19 citation statements)

References 28 publications

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“…The study flow diagram for the acute phase SR has been published previously and the delayed phase SR study flow diagram can be found in Appendix SA7. The study‐level data for the acute phase RCTs were previously published 18 while the study‐level data for the delayed phase RCTs are presented in Appendices SA8a and SA8b.…”

Section: Resultsmentioning

confidence: 99%

“…The acute phase CINV SR has been published 18 . Few RCTs were conducted exclusively in pediatric patients (25 out of 296; 8%).…”

Section: Resultsmentioning

confidence: 99%

“…The literature search identified 65,172 citations, of which 744 18 were retrieved for full-text screening for both the acute and delayed phase SRs. A total of 328 RCTs were included across both SRs.…”

Section: Resultsmentioning

confidence: 99%

“…Each SR included parallel arm randomized controlled trials (RCTs) evaluating interventions to prevent: (1) acute phase CINV or (2) delayed phase CINV. The complete methods for the SR evaluating acute phase CINV are published separately 18 . The complete methods for the SR evaluating delayed phase CINV are presented in Appendix SA4.…”

Section: Methodsmentioning

confidence: 99%

“…The methods for synthesis of the acute phase data have been published elsewhere 18 . The methods for meta‐analysis of the delayed phase data were similar and are fully presented in Appendix SA4.…”

Section: Methodsmentioning

confidence: 99%

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Prevention of acute and delayed chemotherapy‐induced nausea and vomiting in pediatric cancer patients: A clinical practice guideline

Patel

Robinson

Cohen³

et al. 2022

Pediatric Blood & Cancer

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This clinical practice guideline provides recommendations for preventing acute and delayed phase chemotherapy‐induced nausea and vomiting (CINV) in pediatric patients. The recommendations are based on two systematic reviews of randomized controlled trials evaluating interventions to prevent (1) acute phase CINV and (2) delayed phase CINV. Recommendations for acute phase and delayed phase CINV prophylaxis are made for patients receiving chemotherapy of varying emetogenicity, as well as for patients not able to receive dexamethasone or a neurokinin‐1 receptor antagonist. Evidence gaps, including antiemetic safety and optimal dosing, were identified.

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Section: Resultsmentioning

confidence: 99%

“…The acute phase CINV SR has been published 18 . Few RCTs were conducted exclusively in pediatric patients (25 out of 296; 8%).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Prevention of acute and delayed chemotherapy‐induced nausea and vomiting in pediatric cancer patients: A clinical practice guideline

Patel

Robinson

Cohen³

et al. 2022

Pediatric Blood & Cancer

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Treatment of breakthrough and prevention of refractory chemotherapy‐induced nausea and vomiting in pediatric cancer patients: Clinical practice guideline update

Patel

Robinson

Phillips

et al. 2023

Pediatric Blood & Cancer

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Application of nurse‐led CINV management scheme based on risk assessment in breast cancer patients

Ning,

Zhang,

Zhi

et al. 2024

Precision Medical Sciences

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BackgroundAs one of the common adverse reactions after chemotherapy in breast cancer patients, chemotherapy‐induced nausea and vomiting (CINV) seriously affects the quality of life of breast cancer patients.ObjectiveTo explore the application effect of nurse‐led CINV management scheme based on risk assessment in breast cancer patients.MethodsThe researchers selected 90 breast cancer patients who received chemotherapy at Jiangsu Cancer Hospital from June 1, 2022, to June 1, 2023. The patients were divided into control group and intervention group. The control group implemented the routine nursing mode, and the intervention group implemented the nurse‐led intervention program based on risk assessment. On this basis, the intervention group applied the symptom management theory to the construction of intervention strategy to compare the CINV situation, quality of life, and psychological distress level between the two groups.ResultsThe frequency of vomiting and the degree of nausea in the delayed stage were lower in the intervention group than in the control group, and the difference was statistically significant (p<.05). The life function index of nausea and vomiting in acute stage and delayed stage was higher in the intervention group than in the control group, and the differences were statistically significant (p<.05). The psychological pain scores of the two groups in the acute stage and the delayed stage were lower in the intervention group than in the control group, and the differences were statistically significant (p<.05).ConclusionNurse‐led CINV management scheme based on risk assessment can effectively reduce the frequency of vomiting, reduce the degree of nausea, improve the quality of life, and alleviate psychological pain in breast cancer patients.

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Interventions for the prevention of acute phase chemotherapy-induced nausea and vomiting in adult and pediatric patients: a systematic review and meta-analysis

Cited by 12 publications

References 28 publications

Prevention of acute and delayed chemotherapy‐induced nausea and vomiting in pediatric cancer patients: A clinical practice guideline

Prevention of acute and delayed chemotherapy‐induced nausea and vomiting in pediatric cancer patients: A clinical practice guideline

Treatment of breakthrough and prevention of refractory chemotherapy‐induced nausea and vomiting in pediatric cancer patients: Clinical practice guideline update

Application of nurse‐led CINV management scheme based on risk assessment in breast cancer patients

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