Cochrane Database of Systematic Reviews 2010
DOI: 10.1002/14651858.cd008394
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Interventions for treating leg ulcers in people with sickle cell disease

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Cited by 14 publications
(31 citation statements)
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“…It is hypothesized that excessive vasoconstriction, anemia, mechanical circulatory obstruction, and decreased nitric oxide levels are likely contributing factors [ 1 ]. Unfortunately, SCD-associated leg ulcers can be highly resistant to therapy; further compounding this is the fact that they are severely painful, contributing to chronicity and psychosocial burden [ 8 ]. In addition, the healing time for SCD leg ulcers can range from months to years and often times, there is a high likelihood of recurrence [ 9 ].…”
Section: Introductionmentioning
confidence: 99%
“…It is hypothesized that excessive vasoconstriction, anemia, mechanical circulatory obstruction, and decreased nitric oxide levels are likely contributing factors [ 1 ]. Unfortunately, SCD-associated leg ulcers can be highly resistant to therapy; further compounding this is the fact that they are severely painful, contributing to chronicity and psychosocial burden [ 8 ]. In addition, the healing time for SCD leg ulcers can range from months to years and often times, there is a high likelihood of recurrence [ 9 ].…”
Section: Introductionmentioning
confidence: 99%
“…SCD leg ulcers are a chronic manifestation of SCD and are the longest-lasting type of ulcer encountered in adults, with one study reporting ulcers lasting up to 300 months (Halabi-Tawil et al, 2008;Minniti et al, 2014). These ulcers are resistant to all treatments (Marti-Carvajal et al, 2014). The long-lasting nature of the ulcer can lead to many complications, including tibiotarsal ankylosis, soft tissue infections, and chronic pain (Halabi-Tawil et al, 2008).…”
Section: Introductionmentioning
confidence: 99%
“…Sickle cell leg ulcers remain one of the most difficult therapeutic problems of SCD. Many interventions have been used, both topical and systemic, without achieving long‐term success (Martí‐Carvajal et al , ). SCLUs are often refractory and indolent to conservative and surgical treatments, taking several months or years to heal (Halabi‐Tawil et al , ); some never heal.…”
mentioning
confidence: 99%
“…Recently, a remarkable short‐term phase 1 study showed that topical stimulation of peri‐wound cutaneous blood flow improved SCLU healing and reduced ulcer size (Minniti et al , ). Other vascular‐directed therapies were also promising (Martí‐Carvajal et al , ). Therefore, local stimulation of the microcirculation and abrogation of chronic inflammation may be helpful to promote ulcer healing in SCLU patients.…”
mentioning
confidence: 99%