Interventions for treating oral mucositis for patients with cancer receiving treatment

Clarkson, Jan; Worthington, Helen V; Furness, Susan; McCabe, Martin; Khalid, Tasneem; Meyer, Stefan

doi:10.1002/14651858.cd001973.pub4

Cited by 277 publications

(106 citation statements)

References 76 publications

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“…A possible limitation to our findings is the small sample size of the included trials. Our finding is partly contradicting a Cochrane review [6] which was recently updated [37]. Our review deviates from their conclusions because we have included more studies and subgroup analyses by dose range and wavelengths.…”

Section: Discussioncontrasting

confidence: 97%

A systematic review with meta-analysis of the effect of low-level laser therapy (LLLT) in cancer therapy-induced oral mucositis

Bjordal¹,

Bensadoun²,

Tunér³

et al. 2011

Support Care Cancer

248

110

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Section: Discussioncontrasting

confidence: 97%

A systematic review with meta-analysis of the effect of low-level laser therapy (LLLT) in cancer therapy-induced oral mucositis

Bjordal¹,

Bensadoun²,

Tunér³

et al. 2011

Support Care Cancer

248

110

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“…Many studies have been carried out on mucositis owing to its importance and although there are various drugs to prevent and treat mucositis (Table 1), there is no gold-standard protocol that is prominently better than the rest. Despite all these treatment options 28,64,133,151 the strategies to reduce oral mucositis are still unclear. This is because there is not enough evidence describing a treatment with proven efficiency to surpass the other treatments.…”

Section: Treatmentmentioning

confidence: 99%

Cancer treatment-induced oral mucositis: a critical review

Rodríguez-Caballero

Torrés-Lagares

Robles-García

et al. 2012

International Journal of Oral and Maxillofacial Surgery

163

113

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Head and neck cancer represents one of the main oncological problems. Its treatment, radiotherapy and chemotherapy leads to mucositis, and other side effects. The authors reviewed high-quality evidence published over the last 25 years on the treatment of cancer treatment-induced oral mucositis. A Medline search for double blind randomized controlled clinical trials between 1985 and 2010 was carried out. The keywords were oral mucositis, radiotherapy, chemotherapy, and head and neck. The different therapeutic approaches found for cancer treatment-induced oral mucositis included: intensive oral hygiene care; use of topical antiseptics and antimicrobial agents; use of anti-inflammatory agents; cytokines and growth factors; locally applied non-pharmacological methods; antioxidants; immune modulators; and homoeopathic agents. To date, no intervention has been able to prevent and treat oral mucositis on its own. It is necessary to combine interventions that act on the different phases of mucositis. It is still unclear which strategies reduce oral mucositis, as there is not enough evidence that describes a treatment with a proven efficiency and is superior to the other treatments for this condition.

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“…Clarkson et al [79] and Worthington et al [43] concluded that topical or systemic GM-CSF cannot be recommended for prevention or treatment of oral mucositis. alloHSCT allogeneic hematopoietic stem cell transplantation, autoHSCT autologous hematopoietic stem cell transplantation (C), RT (chemo)radiation therapy, CT chemotherapy, EGF epidermal growth factor, HD high-dose, H&N head and neck, HSCT hematopoietic stem cell transplantation, iv intravenous, FGF fibroblast growth factor, 5-FU 5-fluoroucil, G-CSF granulocyte-colony stimulating growth factor, GM-CSF granulocyte-macrophage colony-stimulating growth factor, IL-11 interleukin-11, KGF keratinocyte growth factor, P prevention, RT radiotherapy, sc subcutaneously, syst systemically, T treatment, TBI total body irradiation, TGF-β transforming growth factor-beta…”

Section: Granulocyte Colony-stimulating Factormentioning

confidence: 99%

Systematic review of cytokines and growth factors for the management of oral mucositis in cancer patients

Raber-Durlacher

Bültzingslöwen²,

Logan

et al. 2012

Support Care Cancer

113

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Purpose The aim of this project was to review the literature and define clinical practice guidelines for the use of cytokines and growth factor agents for the prevention or treatment of oral mucositis induced by cancer chemotherapy or radiotherapy. Care Cancer (2013) 21:343-355 DOI 10.1007/s00520-012-1594 following three guideline determinations was possible: Recommendation, Suggestion, No guideline possible. Results Sixty-four clinical studies across 11 interventions were evaluated. A recommendation was made for the use of recombinant human KGF-1 (palifermin) at a dose of 60 μg/kg per day for 3 days prior to conditioning treatment and for 3 days post-transplant for prevention of oral mucositis in patients receiving high-dose chemotherapy and total body irradiation followed by autologous stem cell transplantation for hematological malignancies. A suggestion was made against using granulocyte macrophage colony-stimulating factor mouthwash for the prevention of oral mucositis in the setting of high-dose chemotherapy followed by autologous or allogeneic stem cell transplantation. No guideline was possible for any other cytokine or growth factor agents due to inconclusive evidence. Conclusions Of the cytokine and growth factor agents studied for oral mucositis, the evidence only supports use of palifermin in the specific population listed above. Additional welldesigned research is needed on other cytokine and growth factor interventions and in other cancer treatment settings. Methods

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Interventions for treating oral mucositis for patients with cancer receiving treatment

Cited by 277 publications

References 76 publications

A systematic review with meta-analysis of the effect of low-level laser therapy (LLLT) in cancer therapy-induced oral mucositis

A systematic review with meta-analysis of the effect of low-level laser therapy (LLLT) in cancer therapy-induced oral mucositis

Cancer treatment-induced oral mucositis: a critical review

Systematic review of cytokines and growth factors for the management of oral mucositis in cancer patients

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