Interventions for weight reduction in obesity to improve survival in women with endometrial cancer

Kitson, Sarah; Ryan, Neil; MacKintosh, Michelle L.; Edmondson, Richard J.; Duffy, James M N; Crosbie, Emma J.

doi:10.1002/14651858.cd012513.pub2

Cited by 49 publications

(27 citation statements)

References 50 publications

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“…62,63 Few studies have investigated the benefits of weight loss following treatment for endometrial cancer and all have had limited follow up, been underpowered to examine the effect of the intervention on survival and used diet and exercise regimes that failed to achieve substantial weight loss. 64 Only one RCT reported survival at 24 months and found no improvement in overall survival with a lifestyle and behavioural intervention.…”

Section: Long-term Outcomes In Obese Patients With Endometrial Cancermentioning

confidence: 99%

Endometrial cancer and obesity

Kitson

Crosbie

2019

The Obstetric & Gynaecologis

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Key content Of the 20 most common tumour types, endometrial cancer has the strongest association with obesity. Endometrial cancer should be considered in young, obese women with irregular or heavy menstrual bleeding. To reduce the risk of postoperative complications, surgery for endometrial cancer should be performed using minimal access techniques whenever possible. For women who are unfit for, or who decline, surgery, alternative treatments include progestins or radiotherapy, but these have lower efficacy and are associated with a higher risk of disease relapse. Obesity is associated with reduced overall survival following endometrial cancer because of increased cardiovascular mortality; it may also affect disease‐specific survival. Learning objectives To further understanding of the mechanisms through which obesity drives endometrial carcinogenesis. To improve understanding of the potential difficulties associated with the management of endometrial cancer in obese women. To increase knowledge of alternative treatment options for women who are unfit for, or who decline, standard endometrial cancer management. Ethical issues The number of young, premenopausal women with endometrial cancer is increasing – how should these women be managed? Should super‐obese women with endometrial cancer only be treated in cancer centres? After treating a woman's endometrial cancer, how should she be counselled her about her weight and cardiovascular disease risk?

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Section: Long-term Outcomes In Obese Patients With Endometrial Cancermentioning

confidence: 99%

Endometrial cancer and obesity

Kitson

Crosbie

2019

The Obstetric & Gynaecologis

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“…In contrast to the results of bariatric surgery, behavior and lifestyle interventions were not associated with improved overall survival, nor cancer-specific survival or improved health-related quality of life. Nevertheless, the authors pointed out that there was a lack of evidence in this research field [121].…”

Section: Female-specific Cancermentioning

confidence: 99%

Review: Sex-Specific Aspects in the Bariatric Treatment of Severely Obese Women

Jäger

Wolicki

Spohnholz

et al. 2020

IJERPH

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This systematic literature review aims to point out sex-specific special features that are important in the bariatric treatment of women suffering from severe obesity. A systematic literature search was carried out according to Cochrane and Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) guidelines. After the literature selection, the following categories were determined: sexuality and sexual function; contraception; fertility; sex hormones and polycystic ovary syndrome; menopause and osteoporosis; pregnancy and breastfeeding; pelvic floor disorders and urinary incontinence; female-specific cancer; and metabolism, outcome, and quality of life. For each category, the current status of research is illuminated and implications for bariatric treatment are determined. A summary that includes key messages is given for each subsection. An overall result of this paper is an understanding that sex-specific risks that follow or result from bariatric surgery should be considered more in aftercare. In order to increase the evidence, further research focusing on sex-specific differences in the outcome of bariatric surgery and promising treatment approaches to female-specific diseases is needed. Nevertheless, bariatric surgery shows good potential in the treatment of sex-specific aspects for severely obese women that goes far beyond mere weight loss and reduction of metabolic risks.

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“…Bei überwachtem Bewegungstraining traten nach einer Cochrane Metaanalyse keine schwerwiegenden oder lebensbedrohlichen Nebenwirkungen auf, allerdings wurden muskuloskelettale Probleme häufiger beobachtet [24]. Obwohl der Nutzen einer Gewichtsreduktion durch kalorienreduzierte Diät, durch medikamentöse Maßnahmen (Metformin, Statine), bariatrische Operationen und körperliche Betätigung logisch erscheint, fehlen Studien, die dies belegen [24,25].…”

Section: Merkeunclassified

Nachsorge in der gynäkologischen Onkologie

Emons¹

2020

Frauenheilkunde up2date

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Interventions for weight reduction in obesity to improve survival in women with endometrial cancer

Abstract: Interventions for weight reduction in obesity to improve survival in women with endometrial cancer. www.cochranelibrary.comInterventions for weight reduction in obesity to improve survival in women with endometrial cancer (Protocol)

Cited by 49 publications

References 50 publications

Endometrial cancer and obesity

Endometrial cancer and obesity

Review: Sex-Specific Aspects in the Bariatric Treatment of Severely Obese Women

Nachsorge in der gynäkologischen Onkologie

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