Interventions minimizing fatigue in children/adolescents with cancer: An integrative review

Nunes, Michelle Darezzo Rodrigues; Bomfim, Emiliana de Omena; Olson, Kärin; Lopes-Júnior, Luí­s Carlos; Silva-Rodrigues, Fernanda Machado; Lima, Regina Aparecida Garcia de; Nascimento, Lucila Castanheira

doi:10.1177/1367493517752498

Cited by 41 publications

(51 citation statements)

References 53 publications

(125 reference statements)

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“…Thus, CRF ultimately affects the quality of life (QOL) of children with cancer by impeding patients' ability to engage in daily activities [15]. As a result, there is a growing interest in developing non-pharmacological interventions to minimize fatigue and its negative impact on pediatric cancer patients [16,17].…”

Section: Cancer-related Fatigue and Its Impact On Pediatric Cancer Pamentioning

confidence: 99%

Section: Critical Role Of Physical Activity Among Children With Cancermentioning

confidence: 99%

“…Multiple non-pharmacological interventions have been developed to reduce fatigue in children with cancer [16,17]. These include exercise, massage, healing touch, music therapy, acupressure, and health education [16,17]. Reviews of the literature have found that physical activity (PA) is the most frequent target for intervention [16,17].…”

Section: Critical Role Of Physical Activity Among Children With Cancermentioning

confidence: 99%

“…These include exercise, massage, healing touch, music therapy, acupressure, and health education [16,17]. Reviews of the literature have found that physical activity (PA) is the most frequent target for intervention [16,17]. PA is defined as the movement of the body supported by the skeletal muscle with energy expenditure.…”

Section: Critical Role Of Physical Activity Among Children With Cancermentioning

confidence: 99%

See 3 more Smart Citations

A Narrative Review on the Potential of Red Beetroot as an Adjuvant Strategy to Counter Fatigue in Children with Cancer

et al. 2019

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Cancer-related fatigue (CRF) is a debilitating adverse effect among children with cancer and a significant barrier to physical activity (PA) participation. PA interventions are effective at reducing fatigue and improving both quality of life (QOL) and functional outcomes in children with cancer. However, 50–70% of children with cancer do not meet PA guidelines. Thus, adjuvant methods are needed to increase PA participation. Given the growing interest in the use of beetroot juice to reduce exercise-induced fatigue, our narrative review evaluated the potential use of beetroot to improve PA participation to counter CRF and improve QOL. Our review of 249 articles showed a lack of published clinical trials of beetroot in children and adults with cancer. Trials of beetroot use had been conducted in a noncancer population (n = 198), and anticancer studies were primarily in the preclinical phase (n = 40). Although results are promising, with beetroot juice shown to counter exercise-induced fatigue in a variety of athletic and patient populations, its use to counter CRF in children with cancer is inconclusive. Pilot and feasibility studies are needed to examine the potential benefits of beetroot to counter CRF, increase PA participation, and improve QOL in children with cancer.

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Section: Cancer-related Fatigue and Its Impact On Pediatric Cancer Pamentioning

confidence: 99%

Section: Critical Role Of Physical Activity Among Children With Cancermentioning

confidence: 99%

Section: Critical Role Of Physical Activity Among Children With Cancermentioning

confidence: 99%

Section: Critical Role Of Physical Activity Among Children With Cancermentioning

confidence: 99%

See 2 more Smart Citations

A Narrative Review on the Potential of Red Beetroot as an Adjuvant Strategy to Counter Fatigue in Children with Cancer

et al. 2019

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“…16 Some exceptions to this are cancer, juvenile idiopathic arthritis, and Chronic Fatigue Syndrome (CFS) where a wider body of evidence has contributed to an improved understanding of fatigue. In cancer and rheumatoid arthritis, the aetiology of fatigue appears to be both treatment and disease related 5,34 but in MS fatigue has not been linked to treatment.…”

Section: Introductionmentioning

confidence: 99%

Adolescent and parent factors related to fatigue in paediatric multiple sclerosis and chronic fatigue syndrome: A comparative study

Carroll

Chalder

Hemingway

et al. 2019

European Journal of Paediatric Neurology

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Background: Fatigue is a disabling, poorly understood symptom in children and adolescents with multiple sclerosis (caMS), for which effective treatments are lacking. In paediatric Chronic Fatigue Syndrome (CFS), effective psychological interventions have been developed based on psychosocial factors associated with fatigue. This study aimed to identify potentially modifiable factors of fatigue in caMS by comparing caMS, adolescents with CFS, healthy adolescents and their parents on measures of fatigue, psychosocial factors, and neurocognitive functioning. Methods: 175 participants including 30 caMS (15 fatigued, 15 non-fatigued), 30 adolescents with CFS, 30 healthy controls, and their parents were compared on measures of self-and parent-reported fatigue, adolescent and parent cognitive behavioural responses to symptoms, sleep, psychological difficulties, parental distress and objectively measured neurocognitive functioning. Results: Fatigue severity, functional impairment and cognitive behavioural responses to symptoms were equivalent in fatigued caMS and adolescents with CFS, and were significantly higher than in healthy controls and non-fatigued caMS. Neurocognitive functioning was impaired in both caMS groups, but was normal in adolescents with CFS and healthy controls. No between-group differences were identified in adolescent sleep behaviour or psychological difficulties. Parents of all illness groups had more unhelpful cognitions than parents of healthy controls. Psychological distress was elevated in parents of both fatigued groups.

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A pilot study of the effect of a home‐based multimodal symptom‐management program in children and adolescents undergoing chemotherapy

Cheng

Tan

2021

Cancer Reports

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Background Prevalent symptoms that affect children and adolescents throughout the process of cancer diagnosis and treatment include nausea and vomiting, fatigue, pain, mucositis, and anxiety. Aim To examine the effect of a home‐based multimodal symptom‐management program for alleviation of nausea and vomiting, fatigue, pain, mucositis, and anxiety in children and adolescents undergoing chemotherapy for hematological malignancies or solid tumors. Methods In an exploratory pilot randomized study with qualitative interview, patients between 10 and 18 years of age were randomly assigned to either the symptom‐management program plus usual care (intervention group) or usual care (control group). The program consisted of multiple nonpharmacological interventional components. The targeted symptoms were measured at baseline (after diagnosis), at the first 2 weeks of each cycle of chemotherapy, and at 6 months after baseline, using the Memorial Symptom Assessment Scale 10‐18 and the State Anxiety Scale for Children. Results Fifty children (31 boys; mean age, 13.7 years) were randomized either to the intervention group or the control group (25 each) and underwent baseline assessment. A comparison between the groups showed that the intervention group had a significant less fatigue over time (P < .05). However, no differences were found with respect to nausea and vomiting, pain, mucositis, and anxiety between groups. Both children and parents reported a positive experience with the symptom‐management program. Conclusion The home‐based symptom‐management program may have helped to reduce fatigue in children and adolescents undergoing chemotherapy. In addition, qualitative data support the importance of improving children and parents' knowledge, coping skills, and psychological preparation for symptoms associated with chemotherapy.

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Interventions minimizing fatigue in children/adolescents with cancer: An integrative review

Cited by 41 publications

References 53 publications

A Narrative Review on the Potential of Red Beetroot as an Adjuvant Strategy to Counter Fatigue in Children with Cancer

A Narrative Review on the Potential of Red Beetroot as an Adjuvant Strategy to Counter Fatigue in Children with Cancer

Adolescent and parent factors related to fatigue in paediatric multiple sclerosis and chronic fatigue syndrome: A comparative study

A pilot study of the effect of a home‐based multimodal symptom‐management program in children and adolescents undergoing chemotherapy

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