Interventions to Enhance Patient Adherence to Medication Prescriptions

McDonald, Helen; Garg, Amit; Haynes, R. Brian

doi:10.1001/jama.288.22.2868

Cited by 1,031 publications

(797 citation statements)

References 56 publications

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“…However, it is also possible that renal insufficiency may have led to undertreatment of patients with psychosis, as noted previously for patients with depression (15), and as has been demonstrated with cardiovascular disease (16).…”

Section: Discussionmentioning

confidence: 86%

Hospitalized Psychoses after Renal Transplantation in the United States

Abbott¹,

Agodoa

O’Malley

2003

Journal of the American Society of Nephrology

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ABSTRACT. Although it is recommended that renal transplant (RT) candidates routinely undergo screening for mental health–related conditions, national statistics for psychoses after RT have not been reported. This is a historical cohort study of 39,628 renal transplant recipients in the United States Renal Data System between July 1, 1994, and June 30, 1998, and followed until December 31, 1999. Adjusted hazard ratios (AHR) for time to hospitalization for both a primary and secondary discharge diagnosis of psychoses (ICD-9 codes 290.x-299.x) after RT and mortality/graft loss after psychosis were assessed by Cox Regression. In addition, rates of psychosis were compared with 178,986 patients with Medicare as their primary payer who started chronic dialysis from April 1, 1995, to June 29, 1999. The incidence of psychoses was 7.5/1000 person-years (PY) after RT compared with 7.2/1000 PY for all patients on chronic dialysis and 9.6/1000 PY for dialysis patients aged 65 yr or younger. Among RT recipients, graft loss (AHR, 2.97; 95% CI, 2.19 to 4.02), allograft rejection, and cadaveric donation were independently associated with psychosis, which was associated with an increased risk of both death (AHR, 2.09; 95% CI, 1.71 to 2.56; P < 0.001) and graft loss (AHR, 1.79; 95% CI, 1.15 to 2.78; P = 0.01). Graft loss due to noncompliance was significantly more common after psychosis (9.0% versus 3.7% in patients not hospitalized for psychosis; P < 0.001). The incidence of hospitalized psychosis was not substantially higher after RT compared with chronic dialysis patients. Psychoses were independently associated with increased risk of death and graft loss after renal transplantation, possibly mediated through medical non-adherence. E-mail: kevin.abbott@na.amedd.army.mil

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Section: Discussionmentioning

confidence: 86%

Hospitalized Psychoses after Renal Transplantation in the United States

Abbott¹,

Agodoa

O’Malley

2003

Journal of the American Society of Nephrology

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“…Adherence to medication is not necessarily related to sociodemographic factors such as age, sex, level of education or race [5] but rather that patients are less likely to adhere to those therapies that have adverse side-effects [6] are complex and/or last longer [5]. Evidence regarding all these issues has been mixed.…”

Section: Factors Related To Non-adherencementioning

confidence: 99%

Intentional and non-intentional non-adherence to medication amongst breast cancer patients

Atkins

Fallowfield

2006

European Journal of Cancer

220

228

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This study aimed to investigate the prevalence of and factors associated with nonadherence to medication amongst a sample of breast cancer patients. 131 women with stable disease were interviewed and completed standardised psychological measures. 55% of women reported non-adherence to medication frequently or occasionally, with younger women and those who disliked taking their medication being significantly less adherent (P =0.015, P =0.001). Women who deliberately omitted taking their tablets occasionally or frequently had significantly lower scores, indicative of a weaker influence, on 'internal' and 'powerful others' dimensions of health locus of control (P =0.032, P =0.009). Despite a life-threatening diagnosis, patients may not adhere to medication representing a potential missed opportunity for health gain and waste of resources. Furthermore, interpretation of clinical trial data may be misleading without adherence information. More r esear ch is need ed to iden tify those at risk for non-adherence. If other routes of administration are available these options should be discussed with patients to maximise efficacy of therapy.

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“…Many reviews and clinical articles have included suggestions to reduce the complexity of the regimen, usually by decreasing the number of doses per day McDonald et al 2002), while others have concluded that there is no systematic difference between the effects of changing doses and other behavioral interventions (Peterson et al 2003). There are two published reviews on the impact of dosing schedules on adherence in chronic illness (Claxton et al 2001;Richter et al 2003).…”

Section: Introductionmentioning

confidence: 99%

The impact of medication regimen factors on adherence to chronic treatment: a review of literature

2008

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This article reviews recent literature in chronic illness or long-term health management including asthma, contraception, diabetes, HIV disease, and hypertension/cardiovascular disease, mental disorders, pain, and other diseases to determine the relationship between regimen factors and adherence to medications. The authors conducted an electronic literature search to detect articles published between 1998 and 2007. Articles were included if they pertained to a chronic illness or to contraception, included a clear definition of how adherence was measured, and included regimen factors as primary or secondary explanatory variables. Methodology of the studies varied greatly, as did methods of measuring adherence and regimen factors. Surprisingly few of these articles concerned (1) chronic treatment, (2) regimen factors such as dosing, pill burden, and regimen complexity, and (3) adherence measured in a clear manner. Most studies failed to use state-of-theart methods of measuring adherence. Despite these flaws, a suggestive pattern of the importance of regimen factors, specifically dose frequency and regimen complexity, emerged from this review.

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Interventions to Enhance Patient Adherence to Medication Prescriptions

Cited by 1,031 publications

References 56 publications

Hospitalized Psychoses after Renal Transplantation in the United States

Hospitalized Psychoses after Renal Transplantation in the United States

Intentional and non-intentional non-adherence to medication amongst breast cancer patients

The impact of medication regimen factors on adherence to chronic treatment: a review of literature

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